A5048188645- Neuroscience of respiration and sleep
- Sulfur Compounds in Biology
- Heart Rate Variability and Autonomic Control
- Obstructive Sleep Apnea Research
- Heme Oxygenase-1 and Carbon Monoxide
- High Altitude and Hypoxia
- Eicosanoids and Hypertension Pharmacology
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Ion Channels and Receptors
- Biochemical Analysis and Sensing Techniques
- Tryptophan and brain disorders
- Ophthalmology and Visual Impairment Studies
- Visual perception and processing mechanisms
- Neonatal Health and Biochemistry
- Neurobiology and Insect Physiology Research
- Thermoregulation and physiological responses
- Thermal Regulation in Medicine
- Vagus Nerve Stimulation Research
- Neonatal Respiratory Health Research
- Neurotransmitter Receptor Influence on Behavior
- Circadian rhythm and melatonin
- Psychedelics and Drug Studies
- Cannabis and Cannabinoid Research
Universidade Federal de Juiz de Fora
2016-2025
St. Joseph's Hospital and Medical Center
2010-2023
Dignity Health
2023
Innsbruck Medical University
2020
Universidade de Ribeirão Preto
2008-2017
Universidade de São Paulo
2006-2017
Clinics Hospital of Ribeirão Preto
2010-2012
Instituto Argentino de Radioastronomía
2006
We studied N-(2-aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride (M8-B), a selective and potent antagonist of the transient receptor potential melastatin-8 (TRPM8) channel. In vitro, M8-B blocked cold-induced TRPM8-agonist-induced activation rat, human, murine TRPM8 channels, including those on primary sensory neurons. vivo, decreased deep body temperature (T(b)) in Trpm8(+/+) mice rats, but not Trpm8(-/-) mice, thus suggesting an on-target action....
Peripheral chemoreflex activation with potassium cyanide (KCN) in awake rats or the working heart-brainstem preparation (WHBP) produces: (a) a sympathoexcitatory/pressor response; (b) bradycardia; and (c) an increase frequency of breathing. Our main aim was to evaluate neurotransmitters involved mediating sympathoexcitatory component within nucleus tractus solitarii (NTS). In previous studies conscious rats, reflex bradycardia, but not pressor response, reduced by antagonism either...
In the present study, we tested hypothesis that chronic intermittent hypoxia (CIH) produces changes in autonomic and respiratory responses to acute peripheral chemoreflex activation. To attain this goal, 3-week-old rats were exposed 10 days of CIH (6% O(2) for 40 s at 9 min intervals; 8 h day(-1)). They then used obtain a working heart-brainstem preparation and, using unanaesthetized experimental preparation, was activated with potassium cyanide (0.05%, injected via perfusion system),...
Hydrogen sulfide (H(2)S) is a gaseous neuromodulator endogenously produced in the brain by enzyme cystathionine β-synthase (CBS). We tested hypothesis that H(2)S acts within anteroventral preoptic region of hypothalamus (AVPO) modulating production prostaglandin (PG) E(2) (the proximal mediator fever) and cyclic AMP (cAMP). To this end, we recorded deep body temperature (Tb) rats before after pharmacological modulation CBS-H(2)S system combined or not with lipopolysaccharide (LPS) exposure,...
Objective: This article presents the results of laser therapy in crystal (hydroxyapatite, calcium pyrophosphate, and urates) deposition–induced arthritis rats clinical applications humans. Background Data: Microcrystalline arthropathies are prevalent among geriatric patients, who more vulnerable to side effects drugs. The effectiveness for pain relief, free effects, has been reported painful conditions. Methods: Two milligrams each above-mentioned crystals was injected both joints back limbs...
We hypothesized that hydrogen sulphide (H2 S), acting specifically in the anteroventral preoptic region (AVPO - an important integrating site of thermal and cardiorespiratory responses to hypoxia which H2 S synthesis has been shown be increased under hypoxic conditions), modulates ventilatory response.To test this hypothesis, we measured pulmonary ventilation (V˙E) deep body temperature rats before after intracerebroventricular (icv) or intra-AVPO microinjection aminooxyacetate (AOA; CBS...
Ghrelin is a gut-derived peptide that plays role in energy homeostasis. Recent studies have implicated ghrelin systemic inflammation, showing increased plasma levels after endotoxin (lipopolysaccharide, LPS) administration. The aims of this study were (1) to test the hypothesis administration affects LPS-induced fever; and (2) assess putative effects on corticosterone secretion preoptic region prostaglandin (PG) E(2) euthermic febrile rats. Rats implanted with temperature datalogger capsule...
Abstract Aim Hydrogen sulphide (H 2 S) is endogenously produced and plays an important role as a modulator of neuronal functions; however, its modulatory in the central CO chemoreception unknown. The aim present study was to assess H S ventilatory response hypercapnia adult conscious rats. Methods Cystathionine β ‐synthase ( CBS ) cystathionine γ ‐lyase CSE inhibitors (aminooxyacetate: AOA propargylglycine: PAG respectively) donor (sodium sulphide: Na were microinjected into fourth ventricle...
New Findings What is the central question of this study? In fever, most striking response in acute phase reaction systemic inflammation, plasma H 2 S concentration increases. However, role endogenous peripheral fever unknown. main finding and its importance? Endogenous permissive for increased brown adipose tissue thermogenesis to maintain thermal homeostasis cold environments as well mount fever. This expands physiological gaseous modulator a key regulator control health (thermal...