A5104155935- Legionella and Acanthamoeba research
- Bacterial Infections and Vaccines
- Inflammasome and immune disorders
- Antibiotic Resistance in Bacteria
Inserm
2023-2025
Digestive Health Research Institute
2023-2025
École Nationale Vétérinaire de Toulouse
2023-2025
Université Toulouse III - Paul Sabatier
2023-2025
Université de Toulouse
2023-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023-2025
Abstract CprA is a short‐chain dehydrogenase/reductase (SDR) that contributes to resistance against colistin and antimicrobial peptides. The cprA gene conserved across Pseudomonas aeruginosa clades its expression directly regulated by the two‐component system PmrAB. We have shown leads production of outer membrane vesicles (OMVs) block autophagic flux greater capacity activate non‐canonical inflammasome pathway. In murine model sepsis, P. strain deleted for was less virulent than wild‐type...
HlyF, a cytoplasmic short-chain dehydrogenase/reductase (SDR) enzyme encoded by virulence plasmid in Escherichia coli , and its ortholog CprA, the chromosome of Pseudomonas aeruginosa drive production specific outer membrane vesicles (OMVs). These OMVs have been shown to unique abilities disrupt autophagic flux exacerbate inflammatory response host cells. In this study, we demonstrate that these improved cargo delivery efficiency through clathrin-independent pathway direct fusion vesicle...