A5070420199- Heart Rate Variability and Autonomic Control
- Streptococcal Infections and Treatments
- Urticaria and Related Conditions
- Cardiovascular Function and Risk Factors
- Psoriasis: Treatment and Pathogenesis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Syncope and Autonomic Disorders
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders
- Galectins and Cancer Biology
- Brucella: diagnosis, epidemiology, treatment
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Parkinson's Disease Mechanisms and Treatments
- Healthcare Systems and Public Health
- Historical and modern epidemiology studies
- Microbial infections and disease research
- Cardiac Arrhythmias and Treatments
- Gut microbiota and health
- Inflammasome and immune disorders
- ECG Monitoring and Analysis
- Neurological Disorders and Treatments
- Non-Invasive Vital Sign Monitoring
- Immunodeficiency and Autoimmune Disorders
- Dialysis and Renal Disease Management
Global Health Research Center of Central Asia
2023-2024
Semey Medical University
2016-2019
This bibliometric analysis explores the landscape of research on associations between specific genotypes and cardiovascular form diabetic neuropathy. Diabetes mellitus (DM) is a major contributor to premature mortality, primarily due increased susceptibility diseases. The global prevalence DM rising, with projections indicating further increases. Diabetic neuropathy, complication DM, includes subtype, posing challenges in diagnosis management. Understanding genetic basis neuropathy crucial...
We studied associations between rs8193036 polymorphism of IL-17A gene (C737T) and plasma levels in patients with erysipelas healthy subjects a Kazakh population. The was assessed 95 383 control subjects. (rs8193036) by real time polymerase chain reaction. Plasma were 90 enzyme immunoassay. Categorical data analyzed using Pearson's Chi tests odds ratios (OR) % confidence intervals (CI). Continuous Kruskal -Wallis Mann-Whitney Bonferroni correction. found that T allele occurred more frequently...
The absence of an early diagnosis cardiac autonomic neuropathy might increase the risk disease, progressing to irreversible stage. Therefore, this study aims investigate
Background/Objectives. A cardiovascular complication of type 2 diabetes mellitus like coronary artery disease is influenced by a complex interplay between environmental, phenotypic, and genetic factors. The mechanisms in the development this pathology are not established. This study aims to evaluate association polymorphisms rs1011970, rs62560775, rs564398 from 9p21.3 locus with diabetic patients Kazakh population. Methods. total 343 people participated case-control study: control group...
In the pathogenesis of cardiac autonomic neuropathy, disruptions in lipid metabolism occur, which subsequently influence reduction neural blood flow, leading to decreased conductivity heart. It is commonly believed that fat mass and obesity-associatedFTO gene a predisposing for obesity, its polymorphism rs12149832 plays crucial role obesity processes, particularly among Asian population. However, as today, there lack studies examining association this with neuropathy Kazakh The aim: To...
The gut microbiota plays a fundamental role in the host's energy metabolism and development of metabolic diseases such as arterial hypertension, insulin resistance, atherosclerosis. Our study aimed to investigate potential hypertension among individuals Kazakh population without resistance. 16S rRNA gene sequencing faecal samples from 197 subjects was performed. Preliminary binary comparisons composition depending on presence resistance revealed statistically significant differences abundance
Cardiovascular diseases (CVDs) stand as the foremost global cause of mortality, accounting for 32% total deaths in 2019, with 85% attributed to heart attacks and strokes. Individuals Type 2 Diabetes Mellitus (T2DM) exhibit an elevated susceptibility coronary disease (CHD). In numerous studies, it has been established that genetic polymorphism genes influences onset, progression, complications (CHD) type diabetes mellitus (T2DM). The aims this study are employ bibliometric analysis methods...
In clinical practice, heart rate variability (HRV) has not been considered an indicator for the preventive assessment of cardiovascular autonomic neuropathy (CAN). The paper studies HRV in a large, randomly selected group. A cross-sectional study included representative sample 5707 Kazakhs aged 20 years and older from total population 25,454 attached to urban clinic capital Kazakhstan. was drawn individuals who visited examination. CAN diagnosis confirmed using data questionnaires,...
Introduction. It is known that cardiovascular diabetic neuropathy or cardiac autonomic plays a role in the pathogenesis of vascular damage and subsequent artery disease, which can lead to disability. Currently, genetic mechanisms development are interest. Objective study. To evaluate association polymorphisms rs1011970, rs62560775, rs72652411, rs564398 ANRIL gene (CDKN2B) with identify markers complications patients Kazakh population. Materials methods. A case-control study included 67...
Исследование полиморфизмов генов, контролирующих активность цитокинов, является одной из важных задач в выяснении патогенетических звеньев течения заболеваний, принимающих участие не только развитии заболевания, но и позволяющих прогнозировать предрасположенность к заболеванияю, а также персонализировать терапию профилактику заболеваний. На сегодняшний день, несмотря на то, что литературе имеется значительное количество исследований, которых выявлены ассоциации между полиморфизмами генов...
Целью данного исследования является выявление связи полиморфизма гена ИЛ10-1082 GA (rs1800896) с заболеванием рожей у лиц казахской национальности. Материалы и методы: Полиморфизм изучен 206 больных 422 контрольной группы. Из них 143 первичной 63 рецидиврующей рожей. Для генотипирования были выделены геномная ДНК из крови. Генотипирование проводили методом полимеразной цепной реакции в режиме реал-тайм. статистической обработки использовались критерий χ2Пирсона отношение шансов (ОШ) 95%...
Резюме Описан клинический случай острого бруцеллеза, подтвержденного положительными результатами реакции Райта (1:800 и в динамике 1:3200) с клиническими проявлениями преимущественного поражения печени виде гепатита (увеличение печени, желтушная окраска кожи склер, АЛТ – 0,52 мккат/л, общий билирубин 67,68 мкмоль/л, прямой 37,6 непрямой 30,08 мкмоль/л) селезенки абсцесса селезенки, заключение ультразвукового исследования абсцесс селезенки). Отмечается, что современных условиях при бруцеллезе...
Introduction:Cervical dysplasia caused by human papillomavirus is a significant public health concern that might lead to cervical cancer, particularly in the developing world. The cancer preventative screening program Kazakhstan needs more sophisticated methods for improving early detection and management, which can ultimately reduce burden of this disease on women's health. Aim:The aim study was elicit false positive results as major shortcoming current method recommend accurate testing...
Purpose: The study of association polymorphisms IL17A gene (rs8193036; rs2275913) with brucellosis. Methods & Materials: Study Design: Case-control. Group cases - 89 patients brucellosis, and the control group was 414 people who did not suffer from Genotyping carried out by Real-time PCR method in Organic synthesis laboratory "National Center Biotechnologies", Astana, Kazakhstan. Statistical calculations were on a calculator for genetic under Gene Expert program....