A5103130991- Laser-Plasma Interactions and Diagnostics
- Corneal Surgery and Treatments
- Traumatic Ocular and Foreign Body Injuries
- Assisted Reproductive Technology and Twin Pregnancy
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Facial Trauma and Fracture Management
- Ocular Surface and Contact Lens
- Magnetic confinement fusion research
- Trypanosoma species research and implications
- Malaria Research and Control
- Electromagnetic Launch and Propulsion Technology
- Nuclear Physics and Applications
- Mosquito-borne diseases and control
- Particle accelerators and beam dynamics
- Ectopic Pregnancy Diagnosis and Management
- Animal Virus Infections Studies
- Animal health and immunology
- Viral Infections and Outbreaks Research
- Ocular and Laser Science Research
- T-cell and B-cell Immunology
- Research on Leishmaniasis Studies
- Prenatal Screening and Diagnostics
- Immune Response and Inflammation
- Spinal Fractures and Fixation Techniques
Lawrence Livermore National Laboratory
2017-2024
Brooke Army Medical Center
1970-2021
Wilford Hall Ambulatory Surgical Center
1970-2021
Joint Base San Antonio
2007-2021
Marshall University
2020
Creative Commons
2020
Cornell University
2006-2019
Louisiana Department of Natural Resources
2019
United States Army Institute of Surgical Research
2014-2018
The University of Texas Health Science Center at Houston
2013-2017
Two groups of three German shepherd dogs each were inoculated with Leishmania chagasi or donovani amastigotes and the infection was followed for 82 days. The developed a persistent infection, became thin, splenomegaly lymphadenomegaly by 55 days after inoculation. All normocytic, normochromic anemia increasing severity. Thrombocytopenia leukopenia occasionally occurred. Blood tryptophan levels decreased significantly in infected dogs. Increased total serum protein, hypergammaglobulinemia...
The application of an external 26 Tesla axial magnetic field to a D2 gas-filled capsule indirectly driven on the National Ignition Facility is observed increase ion temperature by 40% and neutron yield factor 3.2 in hot spot with areal density approaching what required for fusion ignition [1]. improvements are determined from energy spectral measurements 2.45 MeV neutrons D(d,n)3He reaction, compressed central core B estimated be ∼4.9 kT using 14.1 secondary D(T,n)4He reactions. experiments...
Three German shepherd dogs were inoculated with Leishmania chagasi and three donovani the infection was followed for 82 days. All infected developed splenomegaly lymphadenomegaly. In lymph nodes there a reduction in lymphocyte population paracortical areas, extensive proliferation of macrophages areas medullary cords, follicular hyperplasia, increased numbers plasma cells. The spleen had decreased lymphocytes periarteriolar lymphoid sheaths, these regions, enlargement red pulp clusters...
Rhesus monkeys infected with Trypanosoma rhodesiense developed a proliferative glomerulonephritis associated glomerular deposits consisting of the third component complement (C3), properdin, and IgM. None contained IgG or IgA. The pattern as revealed by immunofluorescence was granular. Sera from animals were hypocomplementemic; radial immunodiffusion some showed depression C3 but not C4 levels. These findings suggest that trypanosomal infections in is related to deposition immunologically...
SUMMARY Calves fed sporocysts of Sarcocystis isolated from the feces dogs and coyotes became anorectic, lost weight, anemic prostrate, died. The most severe pathologic changes occurred between 26 33 days after infection; schizonts were found throughout body. Schizonts not this time. cysts in skeletal cardiac muscles 54 days. Necropsy revealed lymphadenopathy, paleness mucous membranes visceral organs, ascites, hydrothorax, hydropericardium, serous atrophy fat. Ecchymotic or petechial...
Parasitologic, serologic, pathologic, biochemical, and clinical studies were conducted in 15 chimpanzees exposed to Schistosoma japonicum cercariae. Numerous viable eggs passed the feces after a prepatent period of 5 8 weeks. Worm recoveries at autopsy varied considerably, but not evidence was found reduction worm burdens with infections up 17 months' duration. No consistent difference observed percent recovery location worms animals only once or those repeatedly. Most tissues liver large...
We report on the detection of time-dependent B-field amplitude and topology in a laser-driven solenoid. The inferred from both proton deflectometry Faraday rotation ramps up linearly time reaching 210 ± 35 T at end 0.75-ns laser drive with 1 TW 351 nm. A lumped-element circuit model agrees well linear rise suggests that blow-off plasma screens field between plates leading to an increased plate capacitance converts laser-generated hot-electron current into voltage source drives through ALE3D...
Background: The mechanisms of modern warfare unfortunately have lead to many ocular injuries. This study attempts quantify the effect military combat eye protection on incidence injury among US service members engaged in current operations. Methods: We retrospectively gathered data from Joint Theater Trauma Registry patients entering level III hospital facilities Operations Iraqi and Enduring Freedom March 2003 September 2006. presence was primary outcome measure; whereas severity education...
Suturing amniotic membrane to cornea during surgery is time consuming, and sutures may further damage the eye. The authors introduce a novel sutureless, light-activated technique that securely attaches amnion through protein-protein crosslinks.Cryopreserved human membrane, stained with Rose Bengal (RB), was placed over full-thickness wound in deepithelialized rabbit treated green laser. intraocular pressure broke seal (IOP(L)) measured, adhesion measured peel test. influences on bonding...
Despite improved perinatal survival following fetoscopic laser ablation (FLA) for twin-twin transfusion syndrome (TTTS), prematurity remains an important contributor to mortality and morbidity. The objective of the study was identify risk factors complicated preterm delivery after FLA.Retrospective cohort prospectively collected data on maternal/fetal demographics pre-operative, operative postoperative variables 459 patients treated with FLA in three USA fetal centers. Multivariate linear...
To assess the incidence, clinical course, risk factors and outcomes of preterm prelabor rupture membranes (PPROM) after fetoscopic laser surgery (FLS) for twin-twin transfusion syndrome (TTTS).This was a prospective observational cohort study 154 consecutive cases TTTS. PPROM defined as before 34 weeks' gestation. Procedure-to-PPROM PPROM-to-delivery intervals were determined. Relevant preoperative intraoperative variables analyzed by univariate multivariate logistic regression to determine...
Staphylococcal enterotoxin B (SEB) toxoid-containing microspheres were tested for efficacy in rhesus monkeys as a vaccine candidate respiratory SEB toxicosis and toxic shock. Forty randomly separated into 10 groups of four each: 9 vaccinated with the via combinations mucosal nonmucosal routes, 1 group served nonvaccinated controls. Both then challenged high lethal dose aerosol. Monkeys primed an intramuscular followed by intratracheal booster all survived challenge. Overall, generally had...
Application of a magnetic field to an indirect drive inertial confinement fusion target requires diffusion the through high-Z and electrically conducting Hohlraum. The onset external generates eddy currents in Hohlraum wall that result (1) reduction peak at capsule, (2) heating Ohmic dissipation, (3) movement due inward force from current interacting with field. Heating causes increase blackbody radiation which can preheat capsule frozen deuterium–tritium fuel, while motion leads potential...
Magnetizing a cryogenic deuterium–tritium (DT)-layered inertial confinement fusion (ICF) implosion can improve performance by reducing thermal conduction and improving DT-alpha in the hot spot. A room-temperature, magnetized indirect-drive ICF platform at National Ignition Facility has been developed, using high-Z, high-resistivity AuTa4 alloy as hohlraum wall material. Experiments show 2.5× increase deuterium–deuterium (DD) neutron yield 0.8-keV hot-spot temperature with application of 12-T...
The pathology of aerosolized staphylococcal enterotoxin B (SEB) was studied in the nonhuman primate. Six juvenile rhesus monkeys that received multiple lethal inhaled doses SEB developed diarrhea and vomiting within 24 hr followed by depression, dyspnea, shock. Three 6 animals died 52 hr. most striking gross lesion all diffuse severe pulmonary edema. Histologically, edema fluid present peribronchiolar, peribronchial, perivascular interstitium, alveolar septa, alveoli. adventitia vessels...
Electromagnetic launchers suffer a phenomenon referred to as armature transitioning: when the and rails suddenly lose contact with each other, damage can occur of launcher. In this paper, we explore transient elastic waves possible explanation for transitioning solid armatures in electromagnetic launchers. We use finite-element code model dynamics typical launcher guide rail. found that dynamic rail deflections caused by movement are similar magnitude those magnetic field, pressure between...
Antoantibodies to cholesterol were detected and purified from normal (nonimmunized) pig serum. The antibodies assayed by ELISA with crystalline as an Ag C-dependent damage cholesterol-laden liposomes. Intravenous injection of liposomes containing into anesthetized animals caused decreased hemolytic complement titers, induced a reaction consisting transient neutropenia, thrombocytopenia, respiratory distress, cyanosis, pulmonary systemic hypertension, cardiac output. Plasma levels thromboxane...
Abstract Objective To compare a laparoscopy‐assisted fetoscopic approach with an ultrasound‐directed percutaneous for laser photocoagulation of placental anastomoses in cases twin–twin transfusion syndrome (TTTS) anterior placentation. Method We performed retrospective review all that underwent ablation TTTS placenta at Texas Children's Fetal Center from November 2006 to 2008. The two cohorts were identified by chart based on the type approach: vs. ultrasound‐guided uterine entry fetoscopy....
Smallpox, caused by variola virus (VARV), is a devastating human disease that affected millions worldwide until the was eradicated in 1970 s. Subsequent cessation of vaccination has resulted an immunologically naive population would be at risk should VARV used as agent bioterrorism. The development antivirals and improved vaccines to counter this threat facilitated animal models using authentic VARV. Towards end, cynomolgus macaques were identified adequate hosts for VARV, developing...
Summary Considerable evidence, including results of gel chromatography, indicates that antihemophilic factor (AHF; VIII: C) is associated with von Willebrand (vWF; VIIIR: RC or VTIIR: Ag) in citrated plasma. The present study was undertaken to determine whether these factors are also plasma a physiologic calcium ion concentration, an artificial medium using purified and as source vWF. When fresh BaS04-treated native normal passed through column Sepharose CL-4B equilibrated eluted from...
Aotus monkeys infected with the Camp strain of Plasmodium falciparum were studied emphasis on hematologic, parasitologic and serum biochemical changes occurring during course infection. For most infection was lethal, survival times ranging from 4 to 18 days depending size inoculum. Decreases in red blood cell parameters occurred as progressed, but not accompanied by a pronounced reticulocyte response. Leucocyte levels appeared be depressed early infection, rose high some animals that...