A5010613676- Microtubule and mitosis dynamics
- Electrostatics and Colloid Interactions
- Material Dynamics and Properties
- Pickering emulsions and particle stabilization
- Minerals Flotation and Separation Techniques
- Enhanced Oil Recovery Techniques
- Reproductive Biology and Fertility
- Photosynthetic Processes and Mechanisms
- Phase Equilibria and Thermodynamics
- Plant Molecular Biology Research
- Micro and Nano Robotics
- Theoretical and Computational Physics
- Advanced Materials and Mechanics
- Engineering Technology and Methodologies
- Electrohydrodynamics and Fluid Dynamics
- Innovations in Concrete and Construction Materials
- Diatoms and Algae Research
- Advanced Theoretical and Applied Studies in Material Sciences and Geometry
- Liquid Crystal Research Advancements
- Photonic Crystals and Applications
- Field-Flow Fractionation Techniques
- Ovarian function and disorders
- Freezing and Crystallization Processes
- Advanced NMR Techniques and Applications
- Nuclear Structure and Function
Harvard University
2021-2024
New York University
2015-2018
Phase transitions significantly differ between two-dimensional and three-dimensional systems, but the influence of dimensionality on glass transition is unresolved. We use microscopy to study colloidal systems as they approach their at high concentrations, find differences 2D 3D. that in particles can undergo large displacements without changing position relative neighbors, contrast with This related Mermin-Wagner long-wavelength fluctuations phase 2D. However, when measuring particle motion...
Abstract STUDY QUESTION Can the BlastAssist deep learning pipeline perform comparably to or outperform human experts and embryologists at measuring interpretable, clinically relevant features of embryos in IVF? SUMMARY ANSWER The can measure a comprehensive set interpretable either these features, WHAT IS KNOWN ALREADY Some studies have applied developed ‘black-box’ algorithms predict embryo viability directly from microscope images videos but lack interpretability generalizability. Other...
Hydrophobic PMMA colloidal particles, when dispersed in oil with a relatively high dielectric constant, can become highly charged. In the presence of an interface conducting aqueous phase, image charge effects lead to strong binding particles interface, even though are wetted very little by phase. this paper, we study both behavior individual as they approach and interactions between that already interfacially bound. We demonstrate using which minimally phase allows us isolate those due...
During eukaryotic cell division, chromosomes are linked to microtubules (MTs) in the spindle by a macromolecular complex called kinetochore. The bound kinetochore (KMTs) crucial ensuring accurate chromosome segregation. Recent reconstructions electron tomography (Kiewisz et al., 2022) captured positions and configurations of every MT human mitotic spindles, revealing that roughly half KMTs these spindles do not reach pole. Here, we investigate processes give rise this distribution using...
We study the phase behavior of a system charged colloidal particles that are electrostatically bound to an almost flat interface between two fluids. show that, despite fact our experimental consists only $10^{3}$ - $10^{4}$ particles, is consistent with theory melting due Kosterlitz, Thouless, Halperin, Nelson and Young (KTHNY). Using spatial temporal correlations bond-orientational order parameter, we classify samples into solid, isotropic fluid, hexatic phases. demonstrate topological...
During eukaryotic cell division, a microtubule-based structure called the spindle exerts forces on chromosomes. The best-studied forces, including those responsible for separation of sister chromatids, are directed parallel to spindle’s long axis. By contrast, little is known about perpendicular axis, which determine metaphase plate configuration and thus location chromosomes in subsequent nucleus. Using live-cell microscopy, we find that spatially anti-correlated mouse oocyte spindles,...
ABSTRACT During eukaryotic cell division, chromosomes are linked to microtubules (MTs) in the spindle by a macromolecular complex called kinetochore. The bound kinetochore (KMTs) crucial ensuring accurate chromosome segregation. Recent electron tomography reconstructions (Kiewisz et al. 2021) captured positions and configurations of every MT human mitotic spindles, revealing that many KMTs these spindles do not reach pole. Here, we investigate processes give rise this distribution using...
During eukaryotic cell division, a microtubule-based structure called the spindle exerts forces on chromosomes, thereby organizing and segregating them Extensive work demonstrates that acting parallel to axis, including those responsible for separating sister chromatids, are generated by microtubule polymerization depolymerization, molecular-motors. In contrast, little is known about perpendicular which determine configuration of chromosomes at metaphase plate, thus impact nuclear...