A5010127538- Hydrogels: synthesis, properties, applications
- Advanced Polymer Synthesis and Characterization
- Polymer Surface Interaction Studies
- Advanced Drug Delivery Systems
- Pharmacological Effects of Natural Compounds
- Electrospun Nanofibers in Biomedical Applications
- Drug Solubulity and Delivery Systems
- Membrane Separation Technologies
- Supramolecular Chemistry and Complexes
- vaccines and immunoinformatics approaches
- Disaster Response and Management
- Mycobacterium research and diagnosis
- 3D Printing in Biomedical Research
- Tuberculosis Research and Epidemiology
- Crystallization and Solubility Studies
- Research on Leishmaniasis Studies
- Whipple's Disease and Interleukins
- Computational and Text Analysis Methods
- Diverse Approaches in Healthcare and Education Studies
- Autopsy Techniques and Outcomes
- Transgenic Plants and Applications
- Antimicrobial agents and applications
- Injury Epidemiology and Prevention
- Dendrimers and Hyperbranched Polymers
- Aerosol Filtration and Electrostatic Precipitation
Central Salt and Marine Chemicals Research Institute
2019-2023
RMIT University
2022-2023
Academy of Scientific and Innovative Research
2019-2023
Indian Institute of Technology Guwahati
2020
National Institute of Pharmaceutical Education and Research
2020
Kirloskar Hospital
2014
Acceleration of gelation in the biological environment and improvement overall properties a hydrogel is enormous importance. Biopolymer stabilized gold (Au) nanoparticles (NPs) exhibit cytocompatibility therapeutic activity. Hence, situ subsequent property by employing Au NPs an attractive approach. We report that stable accelerate conventional nucleophilic substitution reaction activated halide-terminated poly(ethylene glycol) tertiary amine functional macromolecules, leading to rapid...
Recently, there has been a great interest in the development of innovative wound dressing materials based on natural bioactives, as they can accelerate healing process and address issues related to traditional dressings. The current study focuses developing novel derivative guar gum (GG) gallic acid (GA) using simple, free radical-mediated polymerization reaction aimed at enhancing antioxidant properties GG. Multiple spectroscopic investigations were performed validate GA-GG conjugate. NMR...
The low water solubility of any pharmacoactive molecules limits their pharmacological potential but the parameter cannot compromise, so different approaches are employed to enhance bioavailability. Pharmaceutically active with convey a higher risk failure for drug innovation and development. Pharmacokinetics, pharmacodynamics, several other parameters, such as distribution, protein binding absorption, majorly affected by solubility. Among all pharmaceutical dosage forms, oral forms cover...
Abstract Membrane backwash is one of the most widely used membrane regeneration techniques in large-scale desalination operations and water wastewater treatment applications. It necessary order to enhance life critical managing cost pure water. The estimation optimal conditions very important for improved hollow fiber (HFM) operations. A unique feature HFM lumen side pressure drop, which leads variation flow across length. In this work, effect diameter, structural properties temperature on...
In situ simultaneous formation of both covalent linkages and ion pair is challenging yet necessary to control the biological properties a hydrogel. We report that generation (+N–C) facilitates pairs between polyelectrolytes (PEs) in hydrogel network. Co-injection tertiary amine functional macromolecules reactive poly(ethylene glycol) (PEG) containing negatively charged PE leads conetworks consisting junctions pairs. Our design based on gradual appearance +N–C followed by This strategy...
Hydrogels possessing modulated degradation and release behaviors are beneficial for the biological field. However, modulating degradability behavior of a particular class hydrogels requires major structural alteration cross-linker as well an adjustment in concentration, both which affect initial modulus gelation kinetics. Herein, we address this shortcoming by single step installation leaving nucleophile at termini PEG via ether (O–CH2–Ph–, Cl′-PEG-Cl′) ester (−Ph–COO–, Cl-PEG-Cl) spacers...
Multiblock copolymers (MBCs) are fascinating in the field of biology–polymer chemistry interfaces. Synthesizing libraries MBCs with tailor-made functionality is challenging as it involves multiple steps. Herein, a simple synthesis, analogous to polyurethane/Michael addition reactions, has been introduced obtain library derivatizable MBCs. Nucleophilic substitution polymerization (SNP) poly(ε-caprolactone) and poly(ethylene glycol) blocks containing activated halide termini by primary...
Polymeric hydrogels are promising polymeric functional materials that have been widely used in the biomedical field as an emerging carrier of various therapeutic agents. a therapeutics can leverage therapeutically beneficial outcomes drug delivery than systemic chemotherapy and provide spatial temporal control over release cross-linked three-dimensional networks constructed by hydrophilic polymers they capable absorbing re-taining large amount water. share many physiochemical features with...
In a bid to develop novel immunoprophylactic measure against visceral leishmaniasis (VL), MHC class-II-restricted epitopes of LdODC were identified by reverse vaccinology approach. Five consensus HLA-DRB1*0101-restricted screened. The analysis revealed that the set was presented at least 54 diverse class-II alleles. Based on in silico screening, followed molecular dynamics simulation, population coverage analysis, and HLA cross-presentation ability, five best evaluated. PBMCs isolated from...
Tuberculosis is a disease of varied presentations. In endemic countries, the diagnosis usually made by exclusion. It caused an intracellular bacterium, which stimulates and represses immune system simultaneously means different cytokines. A delicate balance between pro-inflammatory anti-inflammatory stimuli required for effective containment infection with minimal host cell damage. Antitubercular therapy may offset this killing pathogen releasing new antigens in locally infected tissue....