A5084818712- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Chemometric Analyses
- Molecular Biology Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Photoacoustic and Ultrasonic Imaging
- Oral and Maxillofacial Pathology
- Ear and Head Tumors
- Cancer Genomics and Diagnostics
- Advanced Chemical Sensor Technologies
- Radiomics and Machine Learning in Medical Imaging
- Ethics in Clinical Research
- Digital Imaging for Blood Diseases
- Gold and Silver Nanoparticles Synthesis and Applications
- Bacillus and Francisella bacterial research
- AI in cancer detection
Blackpool Teaching Hospitals NHS Foundation Trust
2020-2024
University of Liverpool
2020
Blackpool Victoria Hospital
2020
University of Central Lancashire
2017-2019
Royal Lancaster Infirmary
2016
Blackburn College
2014
University of Leicester
2013
With brain tumour incidence increasing, there is an urgent need for better diagnostic tools. Intraoperatively, tumours are diagnosed using a smear preparation reported by neuropathologist. These have many limitations, including the time taken specimen to reach pathology department and results be communicated surgeon. There also assist with resection rates identifying infiltrative edges intraoperatively improve clearance. We present novel study handheld Raman probe in conjunction gold...
There is an increasing need for inexpensive and rapid screening tests in point-of-care clinical oncology settings. Herein, we develop a swab "dip" test saliva obtained from consenting patients participating lung-cancer-screening programme being undertaken North West England. In pilot study, total of 211 samples (n = 170 benign, 41 designated cancer-positive) were randomly taken during the course this prospective programme. The (sterile Copan blue rayon swabs dipped saliva) analysed using...
Saliva is a largely unexplored liquid biopsy that can be readily obtained noninvasively. Not dissimilar to blood plasma or serum, it contains vast array of bioconstituents may associated with the absence presence disease condition. Given its ease access, use saliva potentially ideal in point-of-care screening diagnostic test. Herein, we developed swab "dip" test from consenting patients participating lung cancer-screening programme being undertaken north-west England. A total 998 samples (31...
Introduction: In order for brain tumours to be successfully treated, maximal resection is beneficial. A method detect infiltrative tumour edges intraoperatively, improving on current methods would clinically useful. Vibrational spectroscopy offers the potential provide a handheld, reagent-free detection.Purpose: This study was designed determine ability of both Raman and Fourier-transform infrared (FTIR) towards differentiating between normal tissue, glioma or meningioma.Method: Unfixed...
Metastatic brain tumors represent a significant proportion of identified intraoperatively. A rapid diagnostic method, circumventing the need for histopathology studies, could prove clinically useful. As many spectroscopic studies have shown ability to differentitate between different tumor types, this technique was evaluated use within metastatic tumors. Spectrochemical approaches [Raman and attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR) spectroscopy] were...
Lung cancer is one of the most commonly occurring malignant tumours worldwide. Although some reference methods such as X-ray, computed tomography or bronchoscope are widely used for clinical diagnosis lung cancer, there still a need to develop new early detection cancer. Especially needed approaches that might be non-invasive and fast with high analytical precision statistically reliable. Herein, we developed swab "dip" test in saliva whereby swabs were analysed using attenuated total...
Pleomorphic salivary adenomas (PAs) are the commonest benign tumours of glandular origin in head and neck. Occasionally PAs undergo malignant transformation to carcinoma-ex-PA can metastasise. More rarely they metastasise without primary tumour. We present a case pleomorphic gland adenoma, presenting 7 years later with multiple liver metastases synchronous pulmonary metastasis. Histological analysis lung lesions confirmed diagnosis metastasising adenoma (MPA). The lesion was fully excised,...
Aims Cancer diagnostics have been evolving rapidly. In England, the new National Health Service Genomic Medicine (GMS) provides centralised access to genomic testing via seven regional Laboratory Hubs. The PATHways survey aimed capture pathologists’ experience with current diagnostic pathways and opportunities for optimisation ensure equitable timely biomarker testing. Methods A nationwide was conducted consultant pathologists from laboratories, direct interviews based on a structured...
Abstract Raman spectroscopy is a fast and sensitive technique able to identify molecular changes in biological specimens. Herein, we report on three cases where microspectroscopy was used distinguish normal vs. oesophageal adenocarcinoma (OAC) (case 1) Barrett’s oesophagus OAC (cases 2 3) non-destructive highly accurate fashion. Normal tissues were discriminated using principal component analysis plus linear discriminant (PCA-LDA) with 97% accuracy (94% sensitivity 100% specificity) 1);...
This study presents ATR-FTIR (attenuated total reflectance Fourier-transform infrared) spectral analysis of ex vivo oesophageal tissue including all classifications to adenocarcinoma (OAC). The article adds further validation previous human studies identifying the potential for spectroscopy in differentiating among classes transformation OAC. Tissue used principal component quadratic discriminant (PCA-QDA), successive projection algorithm (SPA-QDA), and genetic (GA-QDA) algorithms variable...
e13551 Background: Identification of primary tissue origin brain metastases can be histopathologically challenging. Initial diagnosis malignancy provided on intraoperative smears; however, it requires formal histopathological examination along with immunohistochemistry to reach a final diagnosis. On occasion this will still fail determine origin. This study aims demonstrate if Raman spectroscopy is able metastasis three common tumours. Methods: Formalin fixed paraffin embedded from twenty...