A5102788821- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Chemometric Analyses
- Estrogen and related hormone effects
- Lysosomal Storage Disorders Research
- Ovarian cancer diagnosis and treatment
- SARS-CoV-2 detection and testing
- Metabolomics and Mass Spectrometry Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Endometriosis Research and Treatment
- Maternal and fetal healthcare
- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Studies on Chitinases and Chitosanases
- Identification and Quantification in Food
- Biosensors and Analytical Detection
- Reproductive System and Pregnancy
- Cancer Risks and Factors
- Trypanosoma species research and implications
- Maternal and Perinatal Health Interventions
- Reproductive Biology and Fertility
- Endometrial and Cervical Cancer Treatments
- Nanoplatforms for cancer theranostics
- Uterine Myomas and Treatments
- Mycobacterium research and diagnosis
- Multiple and Secondary Primary Cancers
Chesterfield Royal Hospital
2023-2024
Blackpool Teaching Hospitals NHS Foundation Trust
2024
Chhattisgarh Swami Vivekanand Technical University
2024
University of Hull
2022
Gold Coast Hospital
2002-2014
Lancashire Teaching Hospitals NHS Foundation Trust
2006-2011
Lancaster University
2006-2008
Wythenshawe Hospital
2006
Stepping Hill Hospital
2006
Royal Preston Hospital
2006
There is an urgent need for ultrarapid testing regimens to detect the severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] infections in real-time within seconds stop its spread. Current approaches this RNA virus focus primarily on diagnosis by RT-qPCR, which time-consuming, costly, often inaccurate, and impractical general population rollout due laboratory processing. The latency until test result arrives with patient has led further Furthermore, latest antigen rapid tests still...
Expensive and time-consuming methods are currently used to identify manipulated whey protein concentrate (WPC). We tested the application of attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy detect quantify adulteration WPC with wheat flour (WF). ATR-FTIR is based on interaction between IR radiation molecular bonds in samples, allowing capture its vibration energy acquisition spectra information that can be functional groups. Samples were adulterated different...
Infrared (IR) absorbance of cellular biomolecules generates a vibrational spectrum, which can be exploited as “biochemical fingerprint” particular cell type. Biomolecules absorb in the mid-IR (2–20 μm) and Fourier-transform infrared (FTIR) microspectroscopy applied to discriminate different types (exfoliative cervical cytology collected into buffered fixative solution) was evaluated. This consisted free atypia (i.e. normal; n = 60), specimens categorised containing low-grade changes CIN1 or...
Endometriosis is the growth of endometrial tissue outside uterine cavity. Its aetiology remains obscure, and it difficult to diagnose ranging from asymptomatic debilitating disease. Mid-infrared (IR) spectroscopy has become recognised as a potential clinical diagnostic tool. Biomolecules absorb mid-IR (4000 cm−1 400 cm−1) this, biochemical-cell fingerprint in form an absorbance spectrum can be derived. We set out determine if IR could used identify underlying biochemical differences between...
There is an increasing need for inexpensive and rapid screening tests in point-of-care clinical oncology settings. Herein, we develop a swab "dip" test saliva obtained from consenting patients participating lung-cancer-screening programme being undertaken North West England. In pilot study, total of 211 samples (n = 170 benign, 41 designated cancer-positive) were randomly taken during the course this prospective programme. The (sterile Copan blue rayon swabs dipped saliva) analysed using...
In Brief BACKGROUND: Incarceration of the retroverted gravid uterus is an extremely rare diagnosis in third trimester that carries significant maternal operative and postoperative morbidity. CASE: The condition was diagnosed clinically a primigravida. Despite preoperative diagnosis, delivery proved difficult, requiring fetus through posterior wall uterus. Thirty-six hours after patient had pulmonary embolus. CONCLUSION: This case report discusses management incarcerated, with postpartum...
Rapid identification of existing respiratory viruses in biological samples is utmost importance strategies to combat pandemics. Inputting MALDI FT-ICR MS (matrix-assisted laser desorption/ionization Fourier-transform ion cyclotron resonance mass spectrometry) data output into machine learning algorithms could hold promise classifying positive for SARS-CoV-2. This study aimed develop a fast and effective methodology perform saliva-based screening patients with suspected COVID-19, using the...
Saliva is a largely unexplored liquid biopsy that can be readily obtained noninvasively. Not dissimilar to blood plasma or serum, it contains vast array of bioconstituents may associated with the absence presence disease condition. Given its ease access, use saliva potentially ideal in point-of-care screening diagnostic test. Herein, we developed swab "dip" test from consenting patients participating lung cancer-screening programme being undertaken north-west England. A total 998 samples (31...
Endometriosis is a debilitating disease in which apoptotic, genetic, immunological, angiogenic and environmental factors have been implicated. Endocrine-disrupting agents (e.g. dioxins) might be involved. Dioxins, via the arylhydrocarbon receptor (AhR), induce estrogen-metabolizing enzymes CYP1A1 CYP1B1. Elevated expression of γ-SYNUCLEIN (γ-SYN) has associated with hormone-related conditions. Tissue sets consisting eutopic ectopic (ovarian) endometrium from patients stage 3 or 4...
Lung cancer is one of the most commonly occurring malignant tumours worldwide. Although some reference methods such as X-ray, computed tomography or bronchoscope are widely used for clinical diagnosis lung cancer, there still a need to develop new early detection cancer. Especially needed approaches that might be non-invasive and fast with high analytical precision statistically reliable. Herein, we developed swab "dip" test in saliva whereby swabs were analysed using attenuated total...
Abstract The effect of metallic cations, such as Cu++, Hg++, and Ce++++ on the corrosion rate hydrogen absorption by cold-rolled mild steel in 2N H2SO4, containing thiourea allylthiourea at 30 C has been studied systematically. Individual cations inhibit considerably. Low ppm cation additions increase absorption. % inhibition efficiency increases, decreases, with individual increases concentrations. In presence inhibitors lower concentrations electrode potential shifts toward electronegative...
Abstract There is an urgent need for ultra-rapid testing regimens to detect the SARS-CoV-2 [Severe Acute Respiratory Syndrome Coronavirus 2] virus infections in real-time within seconds stop its spread. Current approaches this RNA focus primarily on diagnosis by RT-qPCR, which time-consuming, costly, often inaccurate and impractical general population rollout due laboratory processing. The latency until test result arrives with patient has led further Furthermore, latest antigen rapid tests...
Journal Article Infertility: Evaluation of transvaginal sonography combined with a urinary luteinizing hormone monitor in timing donor insemination Get access D.W. Irons, Irons 1 Department Obstetrics and Gynaecology, 4th Floor Leazes Wing, Royal Victoria InfirmaryNewcastle Upon Tyne NE1 4LP, UK 1To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Singh Human Reproduction, Volume 9, Issue 10, October 1994, Pages...
Identification of pre-diabetes allows intervention to reduce risk diabetes mellitus (DM).
The use of non-invasive tools in conjunction with artificial intelligence (AI) to detect diseases has the potential revolutionize healthcare. Near-infrared spectroscopy (NIR) is a technology that can be used analyze biological samples manner. This study evaluated NIR fingertip neutropenia solid-tumor oncologic patients. A total 75 patients were enrolled study. Fingertip spectra and complete blood counts collected from each patient. pre-processed using Savitzky–Golay smoothing outlier...