A5060727849- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Mathematical Modeling in Engineering
- Legal Systems and Judicial Processes
- Hydrogels: synthesis, properties, applications
- Advanced Harmonic Analysis Research
- Differential Equations and Numerical Methods
- Numerical methods for differential equations
- Carbohydrate Chemistry and Synthesis
- Nanoplatforms for cancer theranostics
- Differential Equations and Boundary Problems
- Advanced Mathematical Physics Problems
- Advanced Drug Delivery Systems
- Cancer therapeutics and mechanisms
- Virus-based gene therapy research
- Synthesis and biological activity
- Click Chemistry and Applications
- Law, Rights, and Freedoms
- Seaweed-derived Bioactive Compounds
- Quinazolinone synthesis and applications
- Legal Education and Practice Innovations
- Synthesis and Biological Evaluation
- Curcumin's Biomedical Applications
- DNA and Nucleic Acid Chemistry
Sacred Heart College
2015-2024
Mahatma Gandhi University
2015-2023
University of Kent
2021
University of Konstanz
2015
Sacred Heart University
2014-2015
University of Kochi
2015
University of Alberta
2011
Wayne State University
2010
Courant Institute of Mathematical Sciences
1975-1984
Red Electrica de Espana (Spain)
1981
Abstract Polymeric nanoparticles, micelles, niosomes, hydrogels and liposomes represent effective drug carriers having huge potential for medical pharmaceutical applications. These systems remain the most important area in medicinal chemistry research. The aforementioned biomaterials can effectively encapsulate release diverse hydrophobic/hydrophilic therapeutic molecules including drugs prodrugs. Applications of these carrier extend to nucleic acids, antibodies proteins which could be...
Nonhomologous DNA end joining ( NHEJ ) is the major double‐strand break DSB repair pathway in mammals. Previously, we have described a small molecule inhibitor, SCR 7, which can inhibit Ligase IV ‐dependent manner. Administration of 7 within cells resulted accumulation breaks, cell death, and inhibition tumor growth mice. In present study, report that parental unstable, be autocyclized into stable form. Both cyclized possess same molecular weight (334.09) formula (C 18 H 14 N 4 OS ), whereas...
Chemotherapy is an indispensable tool in medicine where small molecules act as potential cytotoxic, apoptotic, anti-angiogenic and anti-invasive agents targeting cancer cells. Chemotherapeutic possessing these multifaceted properties are highly warranted now the mortality rate increasing alarmingly. Tetrazole derivatives well known for their pharmacological activity against various types of progression. Herein, six tetrazoles were synthesised by multicomponent reactions (MCR) assessed vitro...
5,6-Bis(benzylideneamino)-2-mercaptopyrimidin-4-ol (SCR7) is a new anti cancer molecule having capability to selectively inhibit non-homologous end joining (NHEJ), one of the DNA double strand break (DSB) repair pathways inside cells. In spite promising potential as an anticancer agent, hydrophobicity SCR7 decreases its bioavailability. Herein entrapment in Pluronic copolymer reported. The size aggregates was determined by transmission electron microscopy (TEM) and dynamic light scattering...
Abstract RNA interference (RNAi) has been emerged as an effective method to silence a particular gene utilizing sequence‐specific mechanism for regulation. It induces target mRNA degradation leading lower illness‐inducing product. RNAi represent conserved mechanism. Novel concept of highly specific silencing genes was revolutionized by the introduction short interfering (siRNA).This helped overcome drawbacks and proved out be safer efficient than its counterpart finding way into...
Nonhomologous end joining (NHEJ) of DNA double strand breaks (DSBs) inside cells can be selectively inhibited by 5,6-bis-(benzylideneamino)-2-mercaptopyrimidin-4-ol (SCR7) which possesses anticancer properties. The hydrophobicity SCR7 decreases its bioavailability is a major setback in the utilization this compound as therapeutic agent. In order to circumvent drawback SCR7, we prepared polymer encapsulated form SCR7. physical interaction and Pluronic® copolymer evident from different...
Many eukaryotic proteins are modified with a glycosylphosphatidylinositol (GPI) anchor at their C-termini. This post-translational modification causes these to be noncovalently tethered the plasma membrane. The synthesis of truncated GPI analogues is reported; compounds were designed for use as soluble substrates transamidase (GPI-T), enzyme that appends onto proteins.
Curcumin in turmeric is responsible for most of the therapeutic effects exhibited by this natural product. Solubility dietary compound very low water at neutral pH and room temperature, which decreases its bioavailability. This turn proves to be a major setback making use curcumin as agent against many diseases, including cancer. Alginate/Pluronic® tri-block copolymer P123 micelles has potential formulation curcumin. Inner core effectively trap-free evidenced analytical data. The...
A chemical inhibitor of antiapoptotic protein, BCL2, known as Disarib, suffers poor solubility in aqueous environments; thereby limiting its potential a chemotherapeutic agent. To overcome this limitation and enhance the therapeutic efficacy we have employed encapsulation small molecule within P123 copolymer matrix. Micelles were synthesized using thin-film hydration technique, comprehensive analysis was undertaken to evaluate resulting micelle properties, including morphology, particle...
Abstract In bio‐medical field, one of the most challenging hurdles connected with development therapeutics is efficient transport and delivery drugs to infected cells human body. Supramolecular chemistry provides innovative designs for effective biological applications such as drug gene delivery. various supramolecular chemistry, macrocyclic molecules calixarenes, cyclodextrins, cucurbiturils, pillar arenes serve ideal hosts that can bind guest based on electron density size their cavities....
Sugar diamino acids (SDAs), which differ from the widely used sugar amino in presence of a second group connected to carbohydrate core, share structural features both and carbohydrates. They can be for preparation linear branched amide-linked oligosaccharide mimetics. Such oligomers carry free groups, are positively charged at neutral pH, spatially defined way and, thus, represent potential class aminoglycoside We report here first examples orthogonally protected furanoid SDAs their use...
Abstract DNA nanostructures have evolved in various ways throughout the years since their discovery, including structures and functions. Because is a component of biological system, it may be utilized to deliver therapeutic molecules without causing any harm body. For delivery, offer several benefits over conventional nanomaterials such as liposomes, polymers gold nanoparticles, carbon materials, etc. Various like drugs, nucleic acids, proteins, combination these agents can delivered with...
Hydrogel beads based on natural polymers like alginate, κ-Carrageenan, and gelatin represent an efficient scaffold for controlled hydrophobic drug delivery. We report herein the development characterization different formulations of hydrogel systems above-mentioned having adequate properties as delivery matrices. Different combinations alginate/κ-Carrageenan alginate/gelatin were developed release compared using curcumin a model drug. Alginate/κ-Carrageenan with 50:50 weight ratio exhibited...