A5045471683- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of heterocyclic compounds
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Crystallography and molecular interactions
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Reactions
- Quinazolinone synthesis and applications
- Cancer therapeutics and mechanisms
- Synthesis of Organic Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Click Chemistry and Applications
- Sulfur-Based Synthesis Techniques
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Cyclopropane Reaction Mechanisms
- Synthesis and Reactivity of Heterocycles
- DNA and Nucleic Acid Chemistry
- DNA Repair Mechanisms
- Synthesis and Characterization of Pyrroles
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
University of Mysore
2016-2025
Hudson Institute
2023
University of Nebraska Medical Center
2023
Thieme Medical Publishers (Germany)
2022
Rutgers, The State University of New Jersey
2014-2015
Jawaharlal Nehru Centre for Advanced Scientific Research
2007-2013
Indian Institute of Science Bangalore
2008
Institute of Bioinformatics and Applied Biotechnology
2008
Abstract Background Post-translational modifications (PTMs) of histones and other proteins are perturbed in tumours. For example, reduced levels acetylated H4K16 trimethylated H4K20 associated with high tumour grade poor survival breast cancer. Drug-like molecules that can reprogram selected histone PTMs cells therefore interest as potential cancer chemopreventive agents. In this study we assessed the effects phytocompounds garcinol curcumin on p53 modification cells, focussing cell line...
Azomethine ylides are accessed under mild conditions via benzoic acid catalyzed condensations of 1,2,3,4-tetrahydroisoquinolines or tryptolines with aldehydes bearing a pendent dipolarophile. These intermediates undergo intramolecular [3 + 2]-cycloadditions in highly diastereoselective fashion to form polycyclic amines four new stereogenic centers. Challenging substrates such as piperidine, morpholine, and thiomorpholine the corresponding reactions at elevated temperatures.
Methylation of the arginine residues histones by methyltransferases has important consequences for chromatin structure and gene regulation; however, molecular mechanism(s) methyltransferase regulation is still unclear, as biological significance methylation at particular residues. Here, we report a novel specific inhibitor coactivator-associated 1 (CARM1; also known PRMT4) that selectively inhibits 17 histone H3 (H3R17). Remarkably, this plant-derived inhibitor, called TBBD (ellagic acid),...
Reversible acetylation of nucleosomal histones and nonhistone proteins play pivotal roles in the regulation all DNA templated phenomenon. Dysfunction enzymes involved acetylation/deacetylation leads to several diseases. Therefore, these are targets for new generation therapeutics. Here, we report synthesis trifluoromethyl phenyl benzamides their effect on histone acetyltransferase (HAT) activity p300. One benzamides, CTPB...
Nonhomologous DNA end joining ( NHEJ ) is the major double‐strand break DSB repair pathway in mammals. Previously, we have described a small molecule inhibitor, SCR 7, which can inhibit Ligase IV ‐dependent manner. Administration of 7 within cells resulted accumulation breaks, cell death, and inhibition tumor growth mice. In present study, report that parental unstable, be autocyclized into stable form. Both cyclized possess same molecular weight (334.09) formula (C 18 H 14 N 4 OS ), whereas...
Highly regioselective synthesis of 2-acyl-4-(het)arylthiazoles and thioethers by the reaction between α-oxothioamides α-bromoketones in absence base DMF presence triethylamine acetonitrile, respectively, has been reported. This thiazole is an important extended work Hantzsch synthesis, which overcomes drawbacks earlier reported methods. The probable mechanisms for formation thiazoles are also presented.
We herein report an unexpected formation of novel 2,3-bis(methylthio)-1,4-di(het)arylbut-2-ene-1,4-diones when methyl ketones are reacted with α-oxodithioesters in the presence sodium hydride DMF followed by treatment iodide. have explored a potential application these key intermediates for synthesis unreported 4,5-bis(methylthio)-3,6-di(het)arylpyridazines reacting them hydrazine potassium hydroxide isopropyl alcohol. proposed possible mechanisms and 4,5-bis(methylthio)-3,6-di(het)arylpyridazines.
A new class of bis(imidazol)vinyl-1,2,4-oxadiazoles were synthesised and their anti-proliferative efficiency was tested against HCT116 A549 cancer cell lines.
Carbonylation of (hetero)aryl iodides/bromides with highly deactivated 2-aminopyridines using Pd-Co(CO)4 bimetallic catalysis is accomplished. The use Co2(CO)8 as a solid CO(g) source enhanced reaction rates observed when compared to CO(g), and excellent yields highlight the versatility developed protocol. A wide range electronically sterically demanding heterocyclic amines employed for this study resulted in amino carbonylated products. methodology was further extended synthesize...
Aurora kinases are essential for chromosomal segregation and cell division thereby important maintaining the proper genomic integrity. There three classes of aurora in humans: A, B, C. kinase A is frequently overexpressed various cancers. The link overexpression tumorigenesis yet to be understood. By employing virtual screening, we have found that anacardic acid, a pentadecane aliphatic chain containing hydroxylcarboxylic from cashew nut shell liquid could docked B. Remarkably, acid potently...
Abstract Targeting DNA repair with small‐molecule inhibitors is an attractive strategy for cancer therapy. Majority of double‐strand breaks in mammalian cells are repaired through nonhomologous end‐joining (NHEJ). It has been shown that NHEJ can block efficient inside cells, leading to cell death. Previously, we have reported SCR7, inhibitor induce tumor regression mice. Later studies different forms SCR7 inhibit Ligase IV‐dependent manner. Recently, derivatized by introducing spiro ring...
Iodine-mediated synthesis of 3-sulfenylimidazo[1,5-<italic>a</italic>]pyridines<italic>via</italic>C–H functionalization has been achieved using dithioesters, 2-methylaminopyridines and sulfonyl hydrazides.