A5018849910- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Cancer Mechanisms and Therapy
- Essential Oils and Antimicrobial Activity
- Bioactive Compounds and Antitumor Agents
- Synthesis of Tetrazole Derivatives
- Multicomponent Synthesis of Heterocycles
- Cytokine Signaling Pathways and Interactions
- Cancer therapeutics and mechanisms
- Curcumin's Biomedical Applications
- Phytochemicals and Antioxidant Activities
- Cholinesterase and Neurodegenerative Diseases
- Galectins and Cancer Biology
- Estrogen and related hormone effects
- Medical and Biological Ozone Research
- Synthesis and Reactions of Organic Compounds
- Medicinal Plant Research
- Silymarin and Mushroom Poisoning
- Clostridium difficile and Clostridium perfringens research
- Ubiquitin and proteasome pathways
- 14-3-3 protein interactions
- Advanced Scientific Research Methods
- Melanoma and MAPK Pathways
Institute of Medical Sciences
2018-2025
Chosun University
2014-2022
Institute of Molecular Medicine
2020-2022
Molina Center for Energy and the Environment
2020
Herein, we report an efficient methodology for the preparation of a heterogeneous sustainable magnetically separable Cu@PANI@Fe 3 O 4 nanocomposite, and its catalytic efficiency in multicomponent reactions synthesis triazolo quinolines triazolyl benzamide derivatives is investigated.
Abstract Cancer remains a complex disease to treat because of four important genetic changes that result in different phenotypes, necessitating treatment modalities and usually ending suboptimal results. Metallic silver (Ag) copper (Cu) composites have been reported as anticancer agents for breast other cancers. In this work, Ag 2 O/CuO were studied functional biocatalysts glucose sensing activity. The prepared using microwave hydrothermal route, cytotoxicity was tested the MTT assay against...
For many years, the primary focus has been on finding effective treatments for Alzheimer's disease (AD), which led to identification of promising therapeutic targets. The necessity AD stage-dependent optimal settings necessitated a herbal therapy strategy. plant species Areca Catechu L. (AC) was selected based traditional uses against CNS-related diseases. AC leaf extract were prepared using Soxhlet extraction method and hydroxyapatite nanoparticles (HAp-NPs) synthesized from same...
A comprehensive demonstration of novel catalytic synthetic pathway using sulfated zirconia (solid acid catalyst) to generate a library bioactive compounds precisely, the benzo[d]thiazole-hydrazone derivatives (4a-n). The are characterized ubiquitous spectroscopic techniques such as, IR, 1H and 13C NMR, HR-Mass. set molecules screened in vitro biological activities namely, antimicrobial, antioxidant, anti-inflammatory anticancer which aptly supported by molecular docking studies. Among...
We show that silymarin, a polyphenolic fl avonoid isolated from milk thistle (Silybum marianum), inhibits cytokine mixture (CM: TNF-α, IFN-γ, and IL-1β)-induced production of nitric oxide (NO) in the pancreatic beta cell line MIN6N8a.Immunostaining Western blot analysis showed silymarin iNOS gene expression.RT-PCR expression dose-dependent manner.We also extracellular signal-regulated protein kinase-1 2 (ERK1/2) phosphorylation.A MEK1 inhibitor abrogated CM-induced nitrite production,...
Synthetic small molecules have been very effective in decimating cancer cells by targeting various aberrantly overexpressed oncogenic proteins. These target proteins involved cell cycle regulation, division, migration, invasion, angiogenesis, and other regulatory to induce apoptosis cells. In this study, we synthesized a novel 1,2,5-trisubstituted benzimidazole chemical library of unveiled their anticancer potential against panel lines such as Jurkat, K-562, MOLT-4, HeLa, HCT116, MIA PaCa-2...
DNA double-strand breaks (DSBs) are one of the most lethal types damage due to fact that unrepaired or mis-repaired DSBs lead genomic instability chromosomal aberrations, thereby causing cell death tumorigenesis. The classical non-homologous end-joining pathway (c-NHEJ) is major repair mechanism for rejoining DSBs, and catalytic subunit DNA-dependent protein kinase (DNA-PKcs) a critical factor in this pathway; however, regulation DNA-PKcs expression remains unknown. In study, we demonstrate...
Abstract A series of heterocyclic disperse azo dyes having pyridone architecture was prepared by a simple, economical and highly efficient diazo‐coupling method. In this method, butyl used as common coupling component changing the five amine moieties. The structural investigations analogous compounds were accomplished various spectroscopic techniques. Further, all examined for their potency towards antibacterial, antituberculosis anticancer activities. results revealed that dye molecules...
In our study, a series of novel 4-aminophenol benzamide-1,2,4-oxadiazole hybrid analogues have been designed and synthesized by condensing 4-hydroxyphenyl arylamides
Abstract An efficient, metal free approach to synthesize multi‐substituted Δ 2 ‐pyrroline derivatives by mild base catalyzed cyclocondensation of malononitrile with Erlenmeyer azlactones via 1,2 addition was developed. The modularity this reaction used assemble a range poly‐substituted pyrrolines. Further, synthesized products were screened for cytotoxic properties on different cancer cell lines such as A549 (Human lung adenocarcinoma cells), HeLa cervical Jurkat chronic myeloid leukemia...
This research explores the diverse applications of copper(0) nanoparticles grafted onto boron carbon nitride nanosheets, using dill leaf extract as a natural reducing and stabilizing agent. nanocatalyst efficiently catalyzes synthesis tetrazole aniline derivatives, demonstrating good recyclability promising potential in cancer therapy. By merging sustainability with innovation, this offers transformative solutions both medical fields.
A novel series of natural compound-caffeic acid derivatives were synthesized by coupling with different substituted amines and alkyl halides in an effort to enhance the anticancer activity explore structure-activity relationship. The structures compounds determined 1H NMR mass spectroscopy analysis. Compounds evaluated for inhibition against HeLa-cervical cancer cell proliferation results revealed that compound (E)-N-(4-cyanobenzyl)-3-(3,4- dihydroxyphenyl)acrylamide (SHC5) exhibited potent...