A5056122458- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Cardiac Arrest and Resuscitation
- Infant Development and Preterm Care
- Congenital Diaphragmatic Hernia Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Ultrasound in Clinical Applications
- Respiratory Support and Mechanisms
- Congenital Heart Disease Studies
- Blood disorders and treatments
- Adolescent and Pediatric Healthcare
- Neutropenia and Cancer Infections
- Mobile Health and mHealth Applications
- Emergency and Acute Care Studies
- Poisoning and overdose treatments
- Anatomy and Medical Technology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune responses and vaccinations
- Pharmaceutical Economics and Policy
- Maternal and Perinatal Health Interventions
- Augmented Reality Applications
- Clinical Nutrition and Gastroenterology
- Acute Lymphoblastic Leukemia research
- Retinopathy of Prematurity Studies
The University of Melbourne
2023-2025
Mercy Hospital for Women
2023-2025
Royal Children's Hospital
2025
Murdoch Children's Research Institute
2023-2024
Royal Women's Hospital
2018-2024
Melbourne Health
2024
Hudson Institute of Medical Research
2018-2024
Monash University
2018-2024
Hudson Institute
2021
John Radcliffe Hospital
2018
IntroductionEndotracheal (ET) epinephrine administration is an option during neonatal resuscitation, if the preferred intravenous (IV) route unavailable.ObjectivesWe assessed whether endotracheal achieved return of spontaneous circulation (ROSC), and maintained physiological stability after ROSC, at standard higher dose, in severely asphyxiated newborn lambs.MethodsNear-term fetal lambs were until asystole. Resuscitation was commenced with ventilation chest compressions. Lambs randomly...
Background Globally, the majority of newborns requiring resuscitation at birth are full term or late-preterm infants. These infants typically have their umbilical cord clamped early (ECC) before moving to a platform, losing potential support placental circulation. Physiologically based clamping (PBCC) is after establishing lung aeration and holds promise as readily available means improving newborn outcomes. In mechanically ventilated lambs, PBCC improved cardiovascular stability reduced...
The increasing frequency and intensity of dengue outbreaks in endemic non-endemic countries requires a rational, evidence based response. To this end, we aimed to collate the experiences number affected countries, identify strengths limitations surveillance, outbreak preparedness, detection response contribute towards development model contingency plan adaptable country needs. study was undertaken five Latin American (Brazil, Colombia, Dominican Republic, Mexico, Peru) Asian (Indonesia,...
IntroductionEarly identification of infants requiring surfactant therapy improves outcomes. We evaluated the accuracy delivery room lung ultrasound (LUS) to predict in very- and extremely preterm infants.MethodsInfants born at <320/7 weeks were prospectively enrolled 2 centres. LUS videos both sides chest obtained 5−10 min, 11−20 1−3 h after birth. Clinicians masked results assessment was provided according local guidelines. graded blinded clinical data. Presence unilateral type 1...
ObjectiveTo determine the causal relationship between exposure to early hyperoxemia and death or major disability in infants with hypoxic-ischemic encephalopathy (HIE).Study designWe analyzed data from Infant Cooling Evaluation (ICE) trial that enrolled newborns ≥35 weeks' gestation moderate-severe HIE, randomly allocated hypothermia normothermia. The primary outcome was sensorineural at 2 years. We included arterial pO2 measured within hours of birth. Using a directed acyclic graph, we...
Background: Current guidelines recommend immediate umbilical cord clamping (UCC) for newborns requiring chest compressions. Physiologically-based (PBCC), defined as delaying UCC until after lung aeration, has advantages over in mildly asphyxiated newborns, but its efficacy asystolic CC is unknown. The aim of this study was to compare the cardiovascular response CCs given prior to, or near-term lambs. Methods: Umbilical, carotid, pulmonary and femoral arterial flows pressures well systemic...
Introduction Recent evidence indicates that respiratory distress (RD) in near-term infants is caused by elevated airway liquid (EL) volume at the beginning of air-breathing after birth. While adverse effects EL volumes on newborn lung function are known, control and breathing patterns shortly birth (&lt;4 h) unknown. We investigated cardiorespiratory spontaneously lambs first hours Methods At 137–8 days gestation (2–3 prior to delivery; term ∼147 days), sterile surgery was performed...
Abstract Hypoxic-ischaemia renders the neonatal brain susceptible to early secondary injury from oxidative stress and impaired autoregulation. We aimed describe cerebral oxygen kinetics haemodynamics immediately following return of spontaneous circulation (ROSC) evaluate non-invasive parameters facilitate bedside monitoring. Near-term sheep fetuses [139 ± 2 (SD) days gestation, n = 16] were instrumented measure carotid artery (CA) flow, pressure, right brachial arterial jugular venous...
Intraosseous access is recommended as a reasonable alternative for vascular during newborn resuscitation if umbilical unavailable, but there are minimal reported data in newborns. We compared intraosseous with intravenous epinephrine administration of severely asphyxiated lambs at birth.Near-term (139 days' gestation) were instrumented antenatally measurement carotid and pulmonary blood flow systemic pressure. Intrapartum asphyxia was induced by cord clamping until asystole. Resuscitation...
Neutropenic patients with bacteraemia need prolonged intravenous antibiotic treatment. Using cytometric bead array technology, we show in children febrile neutropenia that is associated an elevation of at least 1 3 plasma cytokines plus C-reactive protein. The combination interleukin (IL)-8, IL-6, IL-10, and protein values above operator-defined cutoff levels identified 15 16 episodes bacteraemia, making this a potentially useful technique identifying high-risk who should not be discharged...
Recent reports have raised concerns of cardiorespiratory deterioration in some infants receiving respiratory support at birth. We aimed to independently determine whether with a facemask is associated decrease heart rate (HR) late-preterm and term infants.Secondary analysis data from born ≥32+0 weeks gestation 2 perinatal centres Melbourne, Australia. Change HR up 120 s after placement, measured using 3-lead electrocardiography, was assessed every 3 until 60 5 thereafter video recordings.In...
The authors present the youngest reported case of a single oral overdose methotrexate in an otherwise well 19-month-old child who was treated with delayed folinic acid rescue. Initial history revealed possible ingestion up to 10 tablets, each containing 2.5 mg methotrexate. peak level 0.67 µmol/l measured 8 h following ingestion. Depending on protocol, levels that remain greater than 0.05–0.1 for 24–48 are associated risk toxicity. No adverse sequelae were noted during hospital admission...
Randomised trials in emergency settings must quickly confirm eligibility and allocate participants to an intervention group without delaying treatment. We report rapid randomisation during two neonatal resuscitation using the non-commercial REDCap platform accessed via smartphone. This simple, reliable method has wide applicability for settings. What is Known: • need rapidly group. process should not delay New: non-commercial, smartphone-accessible application enabled rapid, accurate at...