A5055688007- Reproductive System and Pregnancy
- Preterm Birth and Chorioamnionitis
- Endometriosis Research and Treatment
- Neuroendocrine regulation and behavior
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy and preeclampsia studies
- Neuropeptides and Animal Physiology
- Antimicrobial Peptides and Activities
- Advanced biosensing and bioanalysis techniques
- Pregnancy and Medication Impact
- Computational Drug Discovery Methods
- COVID-19 Impact on Reproduction
- vaccines and immunoinformatics approaches
- Pharmacological Effects and Assays
- Immune cells in cancer
- Biosimilars and Bioanalytical Methods
- Immune Cell Function and Interaction
- Adrenal Hormones and Disorders
University of Hong Kong
2015-2020
Queen Mary Hospital
2020
Chinese University of Hong Kong
2016-2020
Indian Institute of Science Bangalore
2015
What are the actions of soluble human leukocyte antigen G5 (sHLAG5) on macrophage differentiation?sHLAG5 polarizes differentiation macrophages toward a decidual macrophage-like phenotype, which could regulate fetomaternal tolerance and placental development.sHLAG5 is full-length isoform implicated in immune during pregnancy. Low or undetectable circulating level sHLAG5 first trimester pregnancy associated with complications such as pre-eclampsia spontaneous abortion. Decidual located close...
Does glycodelin-A (GdA) induce conversion of human peripheral blood CD16-CD56bright natural killer (NK) cells to decidual NK (dNK) facilitate placentation?GdA binds via its sialylated glycans and converts them a dNK-like cells, which in turn regulate endothelial cell angiogenesis trophoblast invasion vascular growth factor (VEGF) insulin-like factor-binding protein 1 (IGFBP-1) secretion, respectively.dNK are the most abundant leucocyte population decidua. These express phenotype. Peripheral...
Decidual macrophages constitute 20-30% of the total leukocytes in uterus pregnant women, regulating maternal immune tolerance and placenta development. Abnormal number or activities decidual (dMs) are associated with fetal loss pregnancy complications, such as preeclampsia. Monocytes differentiate into dMs a decidua-specific microenvironment. Despite their important roles pregnancy, exact factors that regulate differentiation remain unclear. Glycodelin-A (PAEP, hereafter referred to GdA) is...