A5077182844- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Extracellular vesicles in disease
- Maternal and fetal healthcare
- Pregnancy and Medication Impact
- COVID-19 Impact on Reproduction
- Endometriosis Research and Treatment
- Preterm Birth and Chorioamnionitis
- Cardiovascular Issues in Pregnancy
Guangzhou Medical University
2023-2025
Guangzhou Women and Children Medical Center
2023-2025
University of Hong Kong
2020-2025
University of Hong Kong - Shenzhen Hospital
2020-2023
Chinese University of Hong Kong
2020-2022
The maternal immune system needs to tolerate the semi-allogeneic fetus in pregnancy. adaptation occurs locally at maternal-fetal interface as well systemically through circulation. Failure paternal antigens may result pregnancy complications, such loss and pre-eclampsia. However, mechanism that regulates tolerance, especially systemic level, is still an enigma. Here we report first-trimester placenta-derived exosomes (pEXOs) contribute tolerance by reprogramming circulating monocytes.pEXOs...
Extracellular vesicles (EVs) are cell-derived, membrane-bound that carry molecular cargo to facilitate communication between cells. During pregnancy, EVs secreted by the syncytiotrophoblast layer of placenta villi, where they mediate functions resident leukocytes and invading extravillous trophoblasts (EVTs) in decidua. This study aims isolate placental (pEVs) from explant examine their regulatory roles on EVT endothelial cell functions. pEVs were successfully isolated ex vivo cultured...
Abstract Pregnancy involves a wide range of adaptations in the maternal body. Maternal immune tolerance toward foreign fetus is critical for successful pregnancy. Decidual macrophages are primary antigen-presenting and phagocytic cells responsible antigen presentation apoptotic cell removal. Their phenotype changes dynamically during Placenta-derived exosomes small vesicles carrying active biological molecules such as microRNAs, proteins, lipids. The placenta-derived have been implicated...
Decidual macrophages constitute 20-30% of the total leukocytes in uterus pregnant women, regulating maternal immune tolerance and placenta development. Abnormal number or activities decidual (dMs) are associated with fetal loss pregnancy complications, such as preeclampsia. Monocytes differentiate into dMs a decidua-specific microenvironment. Despite their important roles pregnancy, exact factors that regulate differentiation remain unclear. Glycodelin-A (PAEP, hereafter referred to GdA) is...