A5013395434- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Colorectal and Anal Carcinomas
- Pelvic floor disorders treatments
- Genital Health and Disease
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Urological Disorders and Treatments
- Cancer survivorship and care
- Molecular Biology Techniques and Applications
- Urologic and reproductive health conditions
- HER2/EGFR in Cancer Research
- Ovarian cancer diagnosis and treatment
- Cytokine Signaling Pathways and Interactions
- Virus-based gene therapy research
- Sarcoma Diagnosis and Treatment
- Urinary Tract Infections Management
- Cancer-related molecular mechanisms research
- Reproductive tract infections research
- Cancer and Skin Lesions
- Cancer Risks and Factors
- Immunotherapy and Immune Responses
- Urinary and Genital Oncology Studies
- Inflammatory mediators and NSAID effects
- Maternal and fetal healthcare
University of Amsterdam
1998-2018
Amsterdam UMC Location University of Amsterdam
2004-2016
The Netherlands Cancer Institute
2001-2006
University of Groningen
1993-1999
Delft University of Technology
1997
Martini Ziekenhuis
1996
DDL Diagnostic Laboratory
1993
Dialyse Centrum Groningen
1992
Human papillomavirus (HPV) can be detected by amplification of viral DNA. A novel PCR primer set generating a short fragment (SPF PCR) was used for only 65 bp from the L1 region and permitted ultrasensitive detection broad spectrum HPV genotypes. The intra- intertypic sequence variations 22-bp interprimer this amplimer were studied. Among 238 sequences GenBank clinical specimens, genotypes correctly identified based on in 232 cases (97.2%). Genotype-specific probes 6, 11, 16, 18, 31, 33 to...
Alternatives to surgery are needed for the treatment of vulvar intraepithelial neoplasia. We investigated effectiveness imiquimod 5% cream, a topical immune-response modulator, this condition.Fifty-two patients with grade 2 or 3 neoplasia were randomly assigned receive either placebo, applied twice weekly 16 weeks. The primary outcome was reduction more than 25% in lesion size at 20 Secondary outcomes histologic regression, clearance human papillomavirus (HPV) from lesion, changes immune...
Abstract BACKGROUND The objective of this study was to determine whether modifications in the treatment patients with vulvar carcinoma influence rates recurrence and survival. METHODS Between 1982 1997, 253 T1 T2 invasive squamous cell vulva were treated by essentially same team gynecologic oncologists, 168 (Group I) underwent radical vulvectomy en bloc inguinofemoral lymphadenectomy. Standard therapy changed 1993, 85 II) wide local excision lymphadenectomy through separate incisions....
In the management of early stage cervical cancer, knowledge about prognosis is critical. Although many factors have an impact on survival, their relative importance remains controversial. This study aims to develop a prognostic model for survival in cancer patients and reconsider grounds adjuvant treatment.A multivariate Cox regression was used identify weight clinical histological disease-specific (DSS) 710 consecutive who had surgery (FIGO [International Federation Gynecology Obstetrics]...
Abstract Cervical scrapes from 80 women with a positive cytology result were tested for the presence of human papillomavirus (HPV) using polymerase chain reaction (PCR) and compared to results obtained modified filter in situ hybridisation (FISH) Southern‐blot techniques. The sensitivity FISH was similar, HPV detected 46% patients. PCR appeared be higher, 70% HPV‐DNA could 46 68 patients mild dysplasia, 6 8 severe all 4 carcinoma situ. In 18 (21%) more than one type by PCR. control group...
Identification of risk factors for urinary retention after vaginal prolapse surgery.The medical records 345 women undergoing surgical correction symptomatic pelvic organ were analyzed. Independent the development post-operative identified by performing univariate and multivariate logistic regression analysis. Variables included in analysis age, parity, body mass index, previous surgery, hysterectomy, menopausal status, degree prolapse, type anesthesia, technique operation time,...
To provide descriptive statistics on hysterectomy for benign gynecological conditions in the Netherlands and to analyze regional temporal variations rates surgical routes.Retrospective cohort study.Dutch hospitals.All women with a 1995-2005.This study is based an analysis of Dutch registry hospital admissions 1995-2005.The age-adjusted rate age- diagnosis-adjusted proportion vaginal hysterectomies each healthcare region time period.The average annual crude disease only, was 17.2 per 10,000...
Female genital cosmetic surgeries (FGCSs) and procedures are increasingly being advertised as common, simple, complication-free, capable of not only improving aesthetic appearance but also increasing self-esteem sexual pleasure.Guidelines for physicians clear, scientifically correct information patients must be made available, to minimize the number ineffective or deleterious procedures.The International Society Study Vulvovaginal Disease positions/recommendations regarding FGCS follows:1....
<h3>Objectives:</h3> The aim of the current study was, first, to determine whether laterality lymph node metastases has prognostic significance, independent number metastases. Second was significance extracapsular spread irrespective <h3>Methods:</h3> Data on 134 patients with stage III/IVA vulva cancer from 1982 till 2004 and treated curative intent in either Academic Medical Centre Amsterdam or Mercy Hospital for Women Melbourne were reviewed. impact metastases, spread, bilateral existence...
Background: Differentiated vulvar intraepithelial neoplasia (VIN) is presumed to be the precursor of invasive squamous cell carcinoma (SCC) vulva. It commonly assumed that differentiated VIN related lichen sclerosus (LS). However, evidence for this limited a small number studies describing epithelial alterations adjacent SCC. Aim: To study histology and human papillomavirus (HPV) status in patients with history both LS without coexistent Methods: Original biopsy specimens surgical retrieved...
Urinary catheterisation following vaginal prolapse surgery causes inconvenience for patients, risk of urinary tract infections and potentially longer hospitalisation. Possibly, practice variation exists concerning diagnosis management abnormal postvoid residual (PVR) volume implying suboptimal treatment certain subgroups.
The purpose of this study was to analyze the occurrence ipsilateral, bilateral and contralateral inguinofemoral node metastases in unilateral vulvar carcinoma. One hundred eighty-five women with a T1 or T2 squamous cell carcinoma who underwent radical vulvectomy lymphadenectomy were surveyed. Inguinofemoral lymph found 23 (22.1%) out 104 patients primary tumor. These solely on ipsilateral side 21 (91.3%) patients. patient presented extranodal growth groins. Another history endometrial had...
The aim of this study is to determine immunohistochemical markers with prognostic significance for disease-specific survival in patients squamous cell cancer the vulva. material consisted slides and paraffin blocks 50 vulvectomy specimens. A tissue microarray was constructed stained 16 antibodies. impact lymph node metastases, size tumor, vascular space involvement, marker expression on calculated. In univariate analysis tumor more than 4 cm, strong cyclooxygenase 2 expression, absent...
To identify associations between demographic, disease-related, and psychological variables severe distress from pelvic floor symptoms (PFSs) after cervical cancer treatment.This study was cross-sectional questionnaire based. We included patients with treated 1997 2007 in the Academic Medical Center, Amsterdam. Pelvic were assessed urogenital inventory defecatory inventory. Scores dichotomized into (>90th percentile) versus nonsevere distress. Disease-related extracted medical files....