A5101435546- Spinal Cord Injury Research
- Pain Mechanisms and Treatments
- Drug Transport and Resistance Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- GaN-based semiconductor devices and materials
- MRI in cancer diagnosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Antibiotics Pharmacokinetics and Efficacy
- Spinal Dysraphism and Malformations
- Ga2O3 and related materials
- Ferroptosis and cancer prognosis
- Veterinary Orthopedics and Neurology
- Silk-based biomaterials and applications
- Aortic aneurysm repair treatments
- ZnO doping and properties
- Nanoplatforms for cancer theranostics
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced Nanomaterials in Catalysis
- Neonatal Health and Biochemistry
- Drug Solubulity and Delivery Systems
- Pregnancy-related medical research
- Atherosclerosis and Cardiovascular Diseases
- Protein Interaction Studies and Fluorescence Analysis
- Gynecological conditions and treatments
- Peroxisome Proliferator-Activated Receptors
First Affiliated Hospital of Zhengzhou University
2022-2024
Jinzhou Medical University
2019-2024
Southern Medical University
2023
Pfizer (Japan)
2019
Fuzhou University
2013-2017
State Council of the People's Republic of China
2017
Dalian University of Technology
2013
Dalian University
2013
Pfizer (United States)
2012
Xian Yang Central Hospital
2011
Nanotechnology for tumor diagnosis and optical therapy has attracted widespread interest due to its low toxicity convenience but is severely limited uncontrollable targeting. In this work, homologous cancer cell membrane-camouflaged multifunctional hybrid metal coordination nanoparticles (DRu/Gd@CM) were prepared MRI-guided photodynamic (PDT) photothermal (PTT) of tumors. Bimetallic are composed three functional modules: dopamine, Ru(dcbpy)3Cl2 GdCl3, which connected through...
Abstract Current literature emphasizes surgical complexities and customized resection for managing insular gliomas; however, radiogenomic investigations into prognostic radiomic traits remain limited. We aimed to develop validate a model using multiparametric magnetic resonance imaging (MRI) prediction reveal the underlying biological mechanisms. Radiomic features from preoperative MRI were utilized risk signature (RRS) gliomas, validated through paired RNA‐seq data ( N = 39), identify core...
The magnetic resonance imaging (MRI) findings may overlap due to the complex content of parotid gland tumors and differentiation level malignant tumor (MT); consequently, patients undergo diagnostic lobectomy. This study assessed whether radiomics features could noninvasively stratify accurately based on apparent diffusion coefficient (ADC) maps.This examined diffusion-weighted (DWI) obtained with echo planar sequences. Eighty-eight benign (BTs) [54 pleomorphic adenomas (PAs) 34 Warthin...
To propose a novel noninvasive beat-to-beat arterial blood pressure measurement method based on the Korotkoff sound delay time (KDT) and evaluate its accuracy in preliminary experiments.KDT decreases as cuff P deflates, which can be described by function KDT=f (P). Actually, KDT is of transmural pressure. Therefore, variation obtained pressure, estimated KDT. Holding at an approximate constant between systolic diastolic ΔEBP successive heartbeats according to f'(p), represents corresponding...
Acute kidney injury (AKI) is a prevalent complication of acute aortic dissection (AAD) and associated with poor outcomes. The onset AAD may result in endothelial due to the formation false lumen, which can activate coagulation pathway lead dysfunction. It serves as valuable diagnostic prognostic marker for AAD, but also plays role pathological mechanisms underlying AKI. We aimed investigate potential value indicators at admission assessing in-hospital AKI malignant events after AAD.We...
Objective: Bococizumab, a monoclonal antibody targeting proprotein convertase subtilisin/kexin type 9, has been shown to reduce low-density lipoprotein cholesterol (LDL-C).Here, we describe the pharmacokinetics and pharmacodynamics of bococizumab its effect on particle composition other biomarkers, based double-blind, placebo-controlled, randomized, dose-ranging study.Materials methods: The study consisted two populations: Japanese subjects with uncontrolled LDL-C (LDL-C ≥ 100 mg/dL) despite...
Abstract The pyrroline-5-carboxylate reductase 1 (PYCR1) plays important roles in cancers, but its contribution to adenocarcinoma of the kidney (AK) and potential mechanism remain be clarified. In this study, we aimed demonstrate relationship between PYCR1 mRNA AK based on Cancer Genome Atlas database. normal tissues was compared using Wilcoxon rank sum test. clinicopathological characters evaluated logistic regression. association survival rate Kaplan-Meier test Cox regression univariate...
Eu:GaN nanocrystals have strong fluorescence emission and efficient energy transfer by means of DFT simulations. SiO<sub>2</sub> coating improves the quantum yield.
Abstract We discovered two different anomalous NADPH diaphorase (NADPH-d) positive alterations, which were expressed as aging-related NADPH-d spheroidal bodies and megaloneurites specially distributed in the superficial dorsal horn, gray commissure (DGC), lateral collateral pathway (LCP) sacral parasympathetic nucleus (SPN) aged monkeys’ spinal cord, compared with cervical, thoracic lumbar segments. In gracile of monkeys, only observed no occurred. The dense, abnormal megaloneurites,...
Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) was used to detect neurodegenerations in aged monkeys. Our previous studies have shown that aging-related NADPH-d positive bodies (ANBs) and megaloneurites appeared the lumbosacral spinal cord of rats dogs, respectively. To determine occurrence ANBs non-human primates, we histochemistry perform an advanced study alterations male We identified two distinct abnormal alterations, which were expressed as megaloneurites, mainly...
Abstract NADPH-diaphorase (N-d) activity is commonly used to identify NOS-ergic neurons. In our previous study, N-d positive neuritic dystrophy and spheroid termed aging-related Body discovered in the lumbosacral spinal cord normal aging rats. Histological studies also reveal that neurodegenerative changes occur gracile nucleus. We re-examined nucleus aged rat. found occurred cuneatus trigeminal Besides regular coronal section, longitudinal oriented dystrophic neurites were detected sagittal...
Neuronal lesion or injury is a traditional approach to investigate neural circuit. Is any new pathway neurodegeneration related central nerve system injury? Spinal disc herniation can cause the spinal cord injury. However, histological examination still lack. It happened that case of 10-year old dog was examined with NADPH diaphorase (N-d) histology. We did not find N-d neurodegenerative aberrant in tissue mid-rostral lumber segment besides metamorphoses by compression herniation. severe...
We investigated aging-related changes in nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) the spinal cord of aged dogs. At all levels examined, NADPH-d activities were observed neurons and fibers superficial dorsal horn (DH), gray commissure (DGC) around central canal (CC). A significant number positive macro-diameter fibers, termed megaloneurites, discovered sacral (S1-S3) segments The distribution megaloneurites was characterized from root entry zone (DREZ) into horn, along...
A method of reversed-phase high performance liquid chromatography coupled with diode array detection (HPLC-DAD) was established for the simultaneous determination 6 phenolic acids in green coffee beans. These are caffeic acid, 3-O-caffeoylquinic 4-O-caffeoylquinic 5-O-caffeoylquinic 3,5-O-dicaffeoylquinic acid and 4,5-O-dicaffeoylquinic acid. The separation achieved using a Kromasil C18 column (200 mm x 4.6 mm, 5 microm) under gradient elution mobile phases acetonitrile 0.1% (v/v) formic...
Orally active cephalosporin antibiotics are known to be absorbed from the small intestine via oligopeptide transporter (PepT1). Although several methods have been proposed for prediction of oral absorption in humans, no vitro method has established predict drugs that by a carrier-mediated process. In this mini review, we propose cephalosporins humans studies using rat intestinal brush border membrane vesicles (BBMV) or Caco-2 cells. Uptake into BBMV cells PepT1 was estimated subtracting...
Background We aimed to investigate the feasibility and application of using zoomed diffusion-weighted echo-planar imaging (z-EPI DWI) sequences for hilar cholangiocarcinoma assessment compared with conventional single-shot EPI (c-EPI DWI). Methods Both c-EPI DWI z-EPI were preoperatively performed in 16 patients histopathologically-confirmed cholangiocarcinoma. A two-dimensional spatial-selective radiofrequency (RF) pulse was applied an transmit trajectory. Anatomic structural visualization,...
It has been reported that orally active cephalosporin antibiotics are absorbed from the small intestine via oligopeptide transporter (PepTl). In present study, methods have established to predict oral absorption of cephalosporins using in vitro data obtained with rat intestinal brush border membrane vesicles (BBMV) or Caco-2 cells. Uptake into BBMV cells PepTl was estimated by subtracting uptake at 4°C 25 37°C, which well correlated extent (F) according model Amidon al. The method gave...