A5086864059- Sexual function and dysfunction studies
- Parathyroid Disorders and Treatments
- Lipoproteins and Cardiovascular Health
- Hormonal and reproductive studies
- Cancer, Lipids, and Metabolism
- Pharmacological Effects and Toxicity Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Sexuality, Behavior, and Technology
- Dialysis and Renal Disease Management
- Endometriosis Research and Treatment
- Eating Disorders and Behaviors
- Vitamin D Research Studies
- Electrolyte and hormonal disorders
- Marriage and Sexual Relationships
- Folate and B Vitamins Research
- Family and Disability Support Research
- Gastrointestinal motility and disorders
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Infant Development and Preterm Care
- Diabetes Management and Research
- Neurological and metabolic disorders
- Mobile Health and mHealth Applications
- Telemedicine and Telehealth Implementation
- Cancer Treatment and Pharmacology
University of Michigan
2023-2024
Ardelyx (United States)
2023-2024
Korle Bu Teaching Hospital
2023
Washington State University
2023
University of Sheffield
2023
Holland Bloorview Kids Rehabilitation Hospital
2016-2022
University of Toronto
2016-2022
AMAG Pharmaceuticals (United States)
2019-2022
University Health Network
2022
Williams (United States)
2014-2020
To evaluate the safety and efficacy of bremelanotide for treatment premenopausal women with hypoactive sexual desire disorder.Two identical phase 3, randomized, double-blind, placebo-controlled, multicenter clinical trials (RECONNECT) evaluated 1.75 mg administered subcutaneously as needed in disorder. Patients were randomized 1:1 to 24 weeks or placebo. Sample size was estimated based on simulations from key endpoints patients disorder a prior trial. Coprimary change baseline end-of-study...
Abstract Background Women with a history of spontaneous preterm birth (SPTB) are at significantly increased risk for recurrent (PTB). To date, only one large U.S. clinical trial comparing 17-OHPC (17-α-hydroxyprogesterone caproate or “17P”) to placebo has been published, and this was stopped early due treatment benefit. Objective This study aimed assess whether decreases PTB neonatal morbidity in women prior SPTB singleton gestation. Study Design double-blind, placebo-controlled...
To evaluate the long-term safety and efficacy of bremelanotide as treatment for hypoactive sexual desire disorder in premenopausal women.Women who completed 24-week double-blind core phase RECONNECT, composed two parallel 3 trials (301 302) examining compared with placebo women disorder, could enroll 52-week open-label extension, provided they had not experienced serious adverse events during phase. Efficacy was assessed using coprimary endpoints from phase, all were collected extension. All...
ABSTRACT Ombitasvir (ABT-267) is a hepatitis C virus (HCV) NS5A inhibitor with picomolar potency, pan-genotypic activity, and 50% effective concentrations (EC 50 s) of 0.82 to 19.3 pM against HCV genotypes 1 5 366 genotype 6a. retained these levels potency panel 69 6 chimeric replicons containing the gene derived from HCV-infected patients, despite existence natural sequence diversity within NS5A. In vitro resistance selection identified variants that conferred ombitasvir in at amino acid...
We describe here N-phenylpyrrolidine-based inhibitors of HCV NS5A with excellent potency, metabolic stability, and pharmacokinetics. Compounds 2S,5S stereochemistry at the pyrrolidine ring provided improved genotype 1 (GT1) potency compared to 2R,5R analogues. Furthermore, attachment substituents 4-position central N-phenyl group resulted in compounds potency. Substitution tert-butyl, as compound 38 (ABT-267), low-picomolar EC50 values superior It was discovered that a pan-genotypic...
Educational initiatives related to improving pre-exposure prophylaxis (PrEP) knowledge, confidence, comfort, and awareness remain a priority for those who can prescribe manage PrEP. An interdisciplinary PrEP bootcamp was designed implemented health care professional students included basics, epistemic justice, patient-clinician communication, social determinants of health. A constructivist educational approach used as new knowledge skills when interacting with simulated patient. Three...
To assess whether adding a fibrate to statin therapy reduces residual cardiovascular risk associated with elevated triglycerides and low high-density lipoprotein cholesterol, The Evaluation of Choline Fenofibrate (ABT-335) on Carotid Intima-Media Thickness (cIMT) in Subjects Type IIb Dyslipidemia Residual Risk Addition Atorvastatin Therapy (FIRST) trial evaluated the effects fenofibric acid (FA) treatment cIMT patients mixed dyslipidemia atorvastatin.This multicenter, double-blind,...
Health care portals have the potential to provide consumers with timely, transparent access health information and engage them in process.The objective was examine use, utility, impact on engagement caregiver-provider communication of a client/family portal providing electronic records (EHRs) secure, 2-way e-messaging providers.We conducted prospective, mixed-methods study involving collection caregivers' usage over 14-month period (from introduction January 2015 end March 2016), Web-based...
Secondary hyperparathyroidism is a common complication of chronic kidney disease, resulting from inactivation vitamin D receptor signaling and phosphate retention. Selective activation receptors with intravenous paricalcitol significantly reduced parathyroid hormone (PTH) levels no significant hypercalcemia or hyperphosphatemia in predialysis hemodialysis (HD) patients. This study investigates the effects oral to reduce PTH patients receiving HD peritoneal dialysis (PD).Eighty-eight were...
<i>Background/Aims:</i> Increased parathyroid activity associated with chronic kidney disease is often managed calcitriol, which can elevate serum calcium (Ca) by increasing bone resorption and intestinal absorption, whereas paricalcitol promotes less resorption. This study compared Ca absorption in hemodialysis patients treated calcitriol versus (dose ratio 1:3). <i>Methods:</i> Patients (n = 22) aged ≧20 years, on maintenance for ≧2 months intact hormone (iPTH)...
By 2020, the child population is projected to have more racial and ethnic minorities make up majority of populations health care organizations will need a system in place that collects accurate reliable demographic data order monitor disparities. The goals this group were establish sample practices, approaches lessons learned with regard race, ethnicity, language, other collection pediatric setting. A panel 16 research clinical professional experts working 10 delivery systems US Canada...
Food allergy is a prevalent, potentially deadly disease caused by inadvertent sensitization to benign food antigens. Pathogenic Th2 cells are major driver for disease, and allergen-specific immunotherapies (AIT) aim increase the allergen threshold required elicit severe allergic symptoms. However, majority of AIT approaches require lengthy treatments convey transient suppression, likely due insufficient targeting pathogenic responses. Here, ability allergen-encapsulating nanoparticles...
Spinal cord injury (SCI) is a life-altering event, which often results in loss of sensory and motor function below the level trauma. Biomaterial therapies have been widely investigated SCI to promote directional regeneration but are limited by their pre-constructed size shape. Herein, design parameters microporous annealed particles (MAPs) with tubular geometries that conform direct axons across defect support functional recovery. MAP tubes prepared from 20-, 40-, 60-micron polyethylene...
This study utilized cytochrome P450 2D6 (CYP2D6) genotypes to explain variability of desipramine pharmacokinetics in a cohort non-poor metabolizer individuals. In an interaction utilizing as probe, genotyping for the CYP2D6*3, *4, *5 and *6 alleles was used screen out CYP2D6 poor metabolizers. Individuals were categorized according these additional (CYP2D6*2, *9, *10, *17, *41 x2). Genotypes individuals heterozygous two or three *2, *17 confirmed by molecular haplotyping. Pharmacokinetic...