BETWEEN THE DATE and the purpose of Sallust's Catiline some connection may reasonably be expected. There is little evidence for exact dating, between obvious limits Catiline's death in 62 35. The tone comparison Caesar Cato implies that they are dead; but this an avowed digression, which, though it date publication final form, cannot used with complete confidence to composition as a whole. references Crassus also suggests dead. Since these part narrative, serve narrow time available after...

Dynamic processes, such as intracellular calcium signaling, are hallmark of cellular biology. As real-time imaging modalities become widespread, a need for analytical tools to reliably characterize time-series data without prior knowledge the nature recordings becomes more pressing. The goal this study is develop signal-processing algorithm MATLAB that autonomously computes parameters characterizing prominent single transient responses (TR) and/or multi-peaks (MPR). corrects signal...

I THAT had once been thrown open for great triumphs, a door renowned Tarpeian modesty, whose threshold was thronged by gilded chariots, and moist with the tearful entreaties of captives, now wounded nocturnal brawls drunkards often complain, smitten unworthy hands, lack not graceless garlands hanging, dead torches lying as sign to those who are shut out.... Meanwhile am driven lamentation grievous complaints, made sadder still through sorrowful vigils suppliant. He never suffers my posts...

Cell migration is a tightly-regulated process that involves protein gradients formed by the Rho family of GTPases, including and Rac. The front (rear) cells generally characterized higher active Rac (Rho) lower (Rac) concentrations. Protein clusters, called adhesions, anchor to their external environment have been shown be dynamic small (stable large) at cell (rear), forming force-transmission points necessary for persistent movement. Differences in adhesion sizes dynamics linked activity....

The P2X4 receptor (P2X4R) is a member of family purinergic channels activated by extracellular ATP through three orthosteric binding sites and allosterically regulated ivermectin (IVM), broad-spectrum antiparasitic agent. Treatment with IVM increases the efficacy to activate P2X4R, slows both desensitization during sustained application deactivation after washout, makes pore permeable NMDG+, large organic cation. Previously, we developed Markov model based on presence one site, which...

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Purinergic P2X7 receptors (P2X7Rs) are trimeric nonselective cation channels possessing three intrasubunit orthosteric binding sites and unidentified number of allosteric sites.In previous work, we showed that the same receptor is capable exhibiting sensitization pore dilation (leading to formation biphasic currents cell death) and/or desensitization a decline in current amplitude life signaling) during sustained application agonists, depending on their concentrations.This was done part by...

What sort of person was Penelope? If Homer were consulted about the casting for a dramatization story, what type would he choose to play her part? this Penelope, whom husband abandoned goddess—more than one goddess, indeed—but in yet felt so little confidence on his return that she almost last household learn identity? One hundred and eight suitors, according Telemachos' careful count, buzzed her; either could not or dismiss them entirely, but put off year after year, while wept absent...

Latin tragedy presents interesting and uneven problems. We have too little evidence from the early period, and, some would say, much later. Horace was dissatisfied with primitive carelessness or clumsiness of tragedians, but their spirit, he judged, natura sublimis et acer; namque spirat tragicum satis etfeliciter audet.' He hoped for a renaissance which combine boldness, loftiness, intensity earlier tragedians carefully developed art. Nor his only approving voice. Virgil at least omitted...