A5062679641- Plant Molecular Biology Research
- Neurobiology and Insect Physiology Research
- Regulation of Appetite and Obesity
- Sleep and related disorders
- Biochemical Analysis and Sensing Techniques
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Epigenetics and DNA Methylation
- Genetics, Aging, and Longevity in Model Organisms
- Diet and metabolism studies
- Genomics and Chromatin Dynamics
- Genetics and Neurodevelopmental Disorders
- Plant Gene Expression Analysis
- RNA modifications and cancer
- Invertebrate Immune Response Mechanisms
- Birth, Development, and Health
- Nutrition, Genetics, and Disease
- Plant tissue culture and regeneration
- CRISPR and Genetic Engineering
University of Michigan
2019-2023
Oakland University
2016
Michigan United
2016
Shahid Beheshti University of Medical Sciences
2013-2014
Recent studies find that sugar tastes less intense to humans with obesity, but whether this sensory change is a cause or consequence of obesity unclear. To tackle question, we study the effects high diet on sweet taste sensation and feeding behavior in Drosophila melanogaster. On diet, fruit flies have lower responses stimuli, overconsume food, develop obesity. Excess dietary sugar, not sweetness alone, caused deficits overeating via cell-autonomous action sensor O-linked N-Acetylglucosamine...
Diets high in sugar persistently alter sensory responses to sweetness through the actions of PRC2 complex promote obesity.
Diet profoundly influences brain physiology, but how metabolic information is transmuted into neural activity and behavior changes remains elusive. Here, we show that the enzyme O-GlcNAc Transferase (OGT) moonlights on chromatin of D. melanogaster gustatory neurons to instruct in accessibility transcription underlie sensory adaptations a high-sugar diet. OGT works synergistically with Mitogen Activated Kinase/Extracellular signal Regulated Kinase (MAPK/ERK) rolled its effector stripe (also...
Abstract Diets rich in sugar, salt, and fat alter taste perception food intake, leading to obesity metabolic disorders, but the molecular mechanisms through which this occurs are unknown. Here we show that response a high sugar diet, epigenetic regulator Polycomb Repressive Complex 2.1 (PRC2.1) persistently reprograms sensory neurons of D. melanogaster flies reduce sweet sensation promote obesity. In animals fed binding PRC2.1 chromatin gustatory is redistributed repress developmental...
Rapid cycling Brassica rapa, also known as Wisconsin Fast Plants, are a widely used organism in both K-12 and college science education. They an excellent system for genetics laboratory instruction because it is very easy to conduct genetic crosses with this organism, there numerous seed stocks variation Mendelian quantitative traits, they have short generation time, wealth of educational materials instructors using them. Their main deficiency education that none the RCBr has yet been...
Abstract Diet profoundly influences brain physiology, but how nutritional information is transmuted into neural activity and behavior changes remains elusive. Here we show that the metabolic enzyme O-GlcNAc Transferase (OGT) moonlights on chromatin of D. melanogaster gustatory neurons to instruct in accessibility transcription underlie sensory adaptations a high sugar diet. OGT works synergistically with Mitogen Activated Kinase/Extracellular signal Regulated Kinase (MAPK/ERK) rolled its...