A5102830409- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Advanced Battery Materials and Technologies
- Biopolymer Synthesis and Applications
- Conducting polymers and applications
- Virus-based gene therapy research
- Polymer composites and self-healing
- Fuel Cells and Related Materials
- Asymmetric Hydrogenation and Catalysis
- Bacteriophages and microbial interactions
- Nanoplatforms for cancer theranostics
- Chemical Thermodynamics and Molecular Structure
- Photopolymerization techniques and applications
- Advanced battery technologies research
- History and advancements in chemistry
- Viral Infectious Diseases and Gene Expression in Insects
- Inorganic and Organometallic Chemistry
- Dendrimers and Hyperbranched Polymers
- Covalent Organic Framework Applications
- Catalytic C–H Functionalization Methods
- biodegradable polymer synthesis and properties
- Advancements in Battery Materials
Xi'an Jiaotong University
2023-2025
Hainan University
2025
Second Affiliated Hospital of Xi'an Jiaotong University
2025
The efficient conversion of a C-H bond in the polyether chain to other functional groups provides great opportunities for development novel applications many research fields. However, this field is quite underdeveloped due key challenge on controlling selectivity functionalization over cleavage. In work, we report controllable alkylation polyethers under mild conditions via photoinduced iron catalysis. level could be controlled by using different amounts alkenes and various reaction times,...
Proteins have tremendous potential for vaccine development and disease treatment, but multiple extracellular intracellular biological barriers must be overcome before they can exert specific functions in the target tissue. The use of polymers as carriers would greatly improve their bioavailability therapeutic efficiency. Nevertheless, effective protein packaging cell membrane penetration without causing cytotoxicity is particularly challenging, due largely to simultaneous distribution...
mRNA therapeutics hold tremendous promise for disease prevention and treatment. Development of high-performance delivery systems with enhanced transfection efficiency a safety profile will further fulfill their therapeutic potential expedite translation. The synthesis "four-in-one" highly branched poly(β-amino ester)s (O-LhPAEs) is reported by integrating the essential components lipid nanoparticles (LNPs) spleen-selective enrichment nebulization treatment silicosis. 60 O-LhPAEs distinct...
Poly(β-amino ester)s (PAEs) have been widely developed for gene delivery, and hydrophobic modification can further enhance their transfection efficiency. However, systematic manipulation of amphiphilicity PAEs through copolymerization with monomers is time-consuming and, to some extent, uncontrollable. Here, a modular strategy manipulate the PAE/DNA polyplexes. A polymer (DD-C12-122) hydrophilic (DD-90-122) are synthesized separately used as module module, respectively. The polyplexes could...
Abstract To date, significant efforts have been dedicated to improve their ionic conductivity, thermal stability, and mechanical strength of solid polymer electrolytes (SPEs). However, direct monitoring physical chemical changes in SPEs is still lacking. Moreover, existing thermosetting are hardly degradable. Herein, by overcoming the limitation predicted Flory theory, self‐reporting biodegradable hyperbranched poly(β‐amino ester)‐based (HPAE‐SPEs) reported. HPAE successfully synthesized...
Cancer therapy is a global biomedical challenge, and number of promising anticancer therapeutics, such as small-molecule drugs, proteins, nucleic acids, photothermal agents, etc., have been developed or are in development. However, the direct administration therapeutics often fails to achieve desired therapeutic efficacy due their low bioavailability poor tissue selectivity, leading relapse severe side effects immunosuppression, chronic inflammatory responses, mutagenesis, long-term...
Abstract To date, significant efforts have been dedicated to improve their ionic conductivity, thermal stability, and mechanical strength of solid polymer electrolytes (SPEs). However, direct monitoring physical chemical changes in SPEs is still lacking. Moreover, existing thermosetting are hardly degradable. Herein, by overcoming the limitation predicted Flory theory, self‐reporting biodegradable hyperbranched poly(β‐amino ester)‐based (HPAE‐SPEs) reported. HPAE successfully synthesized...