A5082673454- Cancer, Lipids, and Metabolism
- Ovarian cancer diagnosis and treatment
- Advanced Image and Video Retrieval Techniques
- Advanced Neural Network Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Advanced Photocatalysis Techniques
- Drug Transport and Resistance Mechanisms
- Domain Adaptation and Few-Shot Learning
- Lipid metabolism and biosynthesis
- Endometrial and Cervical Cancer Treatments
- PI3K/AKT/mTOR signaling in cancer
- Phytochemistry and Bioactive Compounds
- Covalent Organic Framework Applications
- Estrogen and related hormone effects
- Phytochemical Studies and Bioactivities
- Layered Double Hydroxides Synthesis and Applications
- Cancer Mechanisms and Therapy
- Pharmacogenetics and Drug Metabolism
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Bone and Joint Diseases
- PARP inhibition in cancer therapy
- Metabolomics and Mass Spectrometry Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pregnancy and Medication Impact
University of North Carolina at Chapel Hill
2020-2024
Zhengzhou University
2022-2024
University of Washington
2023-2024
Washington State University
2024
Reprogramming of fatty acid metabolism promotes cell growth and metastasis through a variety processes that stimulate signaling molecules, energy storage, membrane biosynthesis in endometrial cancer. Oleic is one the most important monounsaturated acids human body, which appears to have both pro- anti-tumorigenic activities various pre-clinical models. In this study, we evaluated potential anti-tumor effects oleic cancer cells LKB1fl/flp53fl/fl mouse model increased lipogenesis, inhibited...
Emerging evidence has provided considerable insights into the integral function of reprogramming fatty acid metabolism in carcinogenesis and progression endometrial cancer. Linoleic acid, an essential with highest consumption Western diet regimen, shown pro-tumorigenic or anti-tumorigenic effects on tumor cell growth invasion multiple types However, biological role linoleic cancer remains unclear. In present study, we aimed to investigate functional impact proliferation, invasion, cells a...
Proinflammatory cytokines, which are elevated during inflammation or infections, can affect drug pharmacokinetics (PK) due to the altered expression activity of transporters and/or metabolizing enzymes. To date, such studies have focused on effect cytokines mRNA hepatic and drug-metabolizing However, many antibiotics antivirals used treat infections cleared by renal transporters, including basal organic cation transporter 2 (OCT2), anion 1 3 (OAT1 3), apical multidrug toxin extrusion...
Proinflammatory cytokines, elevated during inflammation caused by infection and/or autoimmune disorders, result in reduced clearance of drugs eliminated primarily cytochrome P450 enzymes (CYPs). However, the effect cytokines on hepatic drug transporter expression or activity has not been well-studied. Here, using plated human hepatocytes (PHHs;
ONC201 is a dopamine receptor D2 (DRD2) antagonist that inhibits tumor growth in preclinical models through ClpP activation to induce integrated stress response pathway and mitochondrial events related inhibition of cell growth, which being explored clinical trials for solid tumors hematological malignancies. In this study, we investigated the anti-tumorigenic effect endometrial cancer lines genetically engineered mouse model cancer.Cell proliferation was assessed by MTT colony formation...
Ovarian cancer is one of the leading causes female death. Emerging evidence suggests that many dietary natural products have anti-tumorigenic activity, including asparagus officinalis. The current study aimed to assess and anti-metastatic effects officinalis on serous ovarian cell lines a transgenic mouse model high grade cancer. Asparagus decreased cellular viability, caused cycle G1 phase arrest induced apoptosis in OVCAR5 SKOV3 cells. Induction inhibition proliferation was rescued by...
Epidemiological and clinical evidence have extensively documented the role of obesity in development endometrial cancer. However, effect fatty acids on cell growth cancer has not been widely studied. Here, we reported that palmitic acid significantly inhibited proliferation cells primary cultures reduced tumor a transgenic mouse model cancer, parallel with increased cellular stress apoptosis decreased adhesion invasion. Inhibition by N-acetyl-L-cysteine effectively reversed effects...
Endometrial cancer is the most common gynecologic and one of only cancers for which incidence mortality steadily increasing. Although curable with surgery in early stages, endometrial presents a significant clinical challenge metastatic recurrent setting few novel treatment strategies emerging past fifty years. Ipatasertib (IPAT) an orally bioavailable pan‑AKT inhibitor, targets all three AKT isoforms has demonstrated anti‑tumor activity pre‑clinical models, trials many types. In present...
Epidemiological and clinical evidence have extensively documented the role of obesity in develop-ment endometrial cancer. However, effect fatty acids on cell growth cancer has not been widely studied. Here we reported that palmitic acid significantly inhibited proliferation cells primary cultures cancer, reduced tumor a transgenic mouse model parallel with increased cellular stress apoptosis decreased adhesion invasion. Inhibition by N-acetyl-L-cysteine effec-tively reversed effects...
Weakly supervised object detection (WSOD) has attracted more and attention since it only uses image-level labels can save huge annotation costs. Most of the WSOD methods use Multiple Instance Learning (MIL) as their basic framework, which regard an instance classification problem. However, these based on MIL tend to converge most discriminative regions different instances, rather than corresponding complete regions, that is, insufficient integrity. Inspired by human habit observing things,...
Poly ADP-ribose polymerase (PARP) inhibitors are effective therapies for cancer patients with homologous recombination (HR) deficient tumors. The imipridone ONC206 is an orally bioavailable dopamine receptor D2 antagonist and mitochondrial protease ClpP agonist that has anti-tumorigenic effects in endometrial via induction of apoptosis, activation the integrated stress response modulation PI3K/AKT signaling. Both PARP imipridones being evaluated clinical trials but have yet to be explored...
Abstract Purpose Although paclitaxel is a promising first-line chemotherapeutic drug for ovarian cancer, acquired resistance to one of the leading causes treatment failure, limiting its clinical application. Asparagus officinalis has been shown have anti-tumorigenic effects on cell growth, apoptosis, cellular stress and invasion various types cancer cells also synergize with inhibit proliferation in cancer. Methods Human lines MES PTX-resistant counterpart MES-TP were used treated alone as...
<b>Abstract ID 95893</b> <b>Poster Board 034</b> <b>Background:</b> The widely used botanical dietary supplement goldenseal is an established clinical inhibitor of cytochrome P450 (CYP) 3A activity, as evidenced by a 40-50% increase in the area under plasma concentration <i>vs</i>. time curve (AUC) CYP3A probe drug midazolam after oral administration. Our recently observed lack change half-life further suggested that interaction occurs primarily intestine. We next developed and verified...
<b>Abstract ID 20942</b> <b>Poster Board 388</b> <i>In vivo</i> studies have shown that the clearance of drugs primarily cleared by cytochrome P450 (CYP) metabolism is reduced during inflammation or infections, potentially resulting in drug toxicity. Inflammation infectious diseases (e.g. HIV, COVID-19) are associated with increased production pro-inflammatory cytokines which known to down-regulate expression activity CYP enzymes. However, their effect on human hepatic transporters has been...
Object detection is an important research in the computer vision area, mainstream object tasks are generally performed on class-balanced datasets, and have made great progress. However, data real scenarios usually presented as long-tailed distributions, there imbalance between number of classes samples, which causes a significant decrease performance detection. Most current algorithms enhance tail at expense accuracy head common classes. In this paper, we adopt Adaptive Effective Class...