A5011401386- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Gastrointestinal motility and disorders
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Adolescent and Pediatric Healthcare
- Antiplatelet Therapy and Cardiovascular Diseases
- Autoimmune and Inflammatory Disorders Research
- Internet of Things and Social Network Interactions
- Congenital gastrointestinal and neural anomalies
- Intestinal Malrotation and Obstruction Disorders
- Eosinophilic Esophagitis
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
Nishijin Hospital
2018-2025
National Institute of Diabetes and Digestive and Kidney Diseases
2021
ProQuest (United States)
2021
Denso (Japan)
2012
Molecular Oncology (United States)
2008
Kyoto Prefectural University of Medicine
2007
Effective treatments for diarrhea-type irritable bowel syndrome (IBS-D) are limited. Hangeshashinto (HST), an anti-inflammatory Kampo medicine, may offer benefits but its efficacy IBS-D requires further investigation. This study evaluated symptom improvement and gut microbiota changes following HST administration. was a multicenter retrospective with prospective analysis of conducted at five affiliated institutions. Patients diagnosed based on the ROME IV criteria between April 2019 December...
Delayed perforation (DP) remains a significant complication of colorectal endoscopic submucosal dissection (ESD). This study analyzed the risk factors, clinical course, and management for DP following ESD. We retrospectively reviewed 4,632 consecutive ESD cases from 13 institutions between January 2006 May 2024. were identified, incidence rate, along with patient/lesion characteristics (as tumor size, location, severe fibrosis) assessed. The including onset timing, initial treatments, need...
Injection solution is important for achieving submucosal elevation in endoscopic dissection (ESD) and various viscous solutions categorized as low-concentration injection (LCS) or high-concentration (HCS) are used. We analyzed the difference between LCS HCS colorectal ESD. This was a prospective, randomized controlled trial at six Japanese institutions. Patients with early neoplastic lesions of ≥ 20 mm were enrolled from March 2022 to September 2023. Sodium alginate (Liftal K, Kaigen Pharma...
Deregulation of E2F1 transcriptional activity is observed in a variety cancers, including hepatocellular carcinoma (HCC). The aim the present study to identify target genes HCC.We determined expression levels for and ten candidate thought be targets primary HCCs using real-time quantitative reverse transcription-PCR assay. Following small interfering RNA (siRNA)-mediated knockdown HCC cell lines, we quantified mRNA genes.E2F1 was significantly over-expressed 41 as compared non-tumorous liver...
Abstract Background We analyzed the efficacy of precutting endoscopic mucosal resection (EMR), which is a method making full or partial circumferential incision around tumor with snare tip for en bloc resection. Methods reviewed cases from 2011 to 2018 in EMR (n = 167) and standard 557) were performed lesions 10 – 30 mm. Precutting was indicated benign 20 mm < difficult. Through propensity score matching two groups, therapeutic outcomes 35 ≥ 98 each group analyzed. Results In sizes...
Background and Aims: The MANTIS Closure Device (MCD: Boston Scientific, USA), a reopenable clip with sharp claw, is closure device used after endoscopic submucosal dissection (ESD). We aimed to evaluate the effectiveness of MCD for fast complete colorectal ESD. Methods: Cases that underwent ESD lesions 20-60 mm between April 2023 January 2024 were reviewed. primary endpoint was defect MCD. Secondary endpoints included time, delayed bleeding (DB), perforation (DP), post-ESD coagulation...
INTRODUCTION: The efficacy of texture and color enhancement imaging (TXI) in the novel light-emitting diode endoscopic system for polyp detection has not been examined. We aimed to evaluate noninferiority additional 30-second (Add-30-s) observation right-sided colon (cecum/ascending colon) with TXI compared narrow band (NBI) detecting missed polyps. METHODS: enrolled 381 patients ≥40 years old who underwent colonoscopy from September 2021 June 2022 3 institutions randomly assigned them...
High-grade dysplasia (HGD) and T1 lesions are accidentally resected by cold snare polypectomy (CSP) the characteristics, follow-up of them has not been reported. In this study, we analyzed histopathological findings recurrence them.This was a multicenter retrospective-cohort study. We collected HGD ≤ 10 mm CSP among 15 520 patients receiving from 2014 to 2019 at nine related institutions, extracted only cases definite colonoscopy after lesions. these tumor's characteristics therapeutic...
Abstract Background and Aim A hemostatic gel, PuraStat (3‐D Matrix, Tokyo, Japan), is used for various gastrointestinal hemostasis. In this study, we analyzed the efficacy of perioperative bleeding (POB) prevention delayed (DB) to colorectal cold snare polypectomy (CSP) with continuous anticoagulant. Methods This was a single‐center, retrospective study. Subjects were lesions 2–9 mm under anticoagulant from 2021 2023 treated POB. The definition POB which did not stop spontaneously by 1.0–1.5...
Abstract Cold snare polypectomy (CSP) has the disadvantage of a lower histopathological complete resection rate (HCRR) because blunt using CSP‐dedicated snares (DSs) causes mucosal retraction into sheath during capture/resection. In this study, attachments are designed to narrow tip's inner diameter from 1.8 1.3‒1.1 mm prevent retraction. Eight prototype with different component characteristics combined these attachments. Additionally, product version DS attachment (Smart Snare Cold) and...
Recently, direct oral anticoagulants (DOACs) have become widely used for preventing thromboembolism. However, postoperative hemorrhage (POH) is a major complication associated with endoscopic mucosal resection (EMR) colorectal lesions. In this multicenter study, we analyzed the incidence of POH after EMR DOACs and explored risk factors.This study was retrospective cohort conducted at 8 Japanese institutions. A total 2062 cases that underwent lesions these institutions from October 2016 to...
This multicenter retrospective study was conducted from September 2019 to 2020 at 5 related institutions among patients ≥ 20 years old diagnosed with chronic constipation whose previous colonoscopic BP had a fair or poor Aronchick score. Two four sachets of PEG+E (13.7 27.4 g/day) were prescribed for 1 week before colonoscopy. We analyzed the rate improvement in BP, effect-related factors, spontaneous bowel movements (SBMs), stool consistency, symptoms, and adverse events.We evaluated 106...
Backgrounds and Aims . Elobixibat is a bile acid transporter inhibitor indicated for constipation. Previous studies were performed mainly the nonelderly biased to female. We analyzed efficacy of elobixibat also elderly male. Materials Methods This was multicenter retrospective cohort study. The subjects patients aged ≥20 years treated chronic constipation from May 2018 November 2019 at 12 related institutions. Patients divided into ≤74 ≥75 old. 10 mg/day prescribed two weeks. then...
Oral sulfate solution (OSS) is used for bowel preparation (BP) during colonoscopy. The way of taking this agent can be a same-day regimen (only on the day colonoscopy) and split (the before receiving it. In study, we analyzed efficacy 480 ml OSS insufficient with high-concentrated polyethylene glycol (H-PEG).This multicenter retrospective study was conducted from December 2021 to 2022 at three related institutions patients aged ≥ 20 years fair or poor Aronchick score BP 1 l H-PEG in previous...
Endoscopic submucosal dissection (ESD) might be difficult to perform in some cases even for experienced endoscopists. Recently, various traction methods have been introduced facilitate ESD procedures, such as clip-with-line (CL), external forceps, clip and snare, internal traction, double scope, magnetic anchor. The procedure using the CL method enhances visibility of operation field during ESD. original is performed follows: with line (e.g., dental floss) attached edge lesion. Traction can...
Abstract Background and study aims We previously demonstrated the efficacy of an additional-30-seconds (Add-30s) observation with linked color imaging (LCI) or narrow band (NBI) cecum ascending colon (right-sided colon) after white light (WLI) for improving adenoma detection rate (ADR) by 3% to 10%. herein compared Add-30s LCI NBI in a large number cases. Patients methods retrospectively collected 1023 1011 cases right-sided 11 affiliated institutions from 2018 2022 propensity score matching...
Background Gastroesophageal reflux disease (GERD) is a condition characterized by of gastric contents, leading to damage the esophageal mucosa and/or unpleasant symptoms, with global prevalence 13%. Although acid-suppressive medications are currently most effective treatments for GERD, they may be ineffective against its symptoms. We therefore investigated efficacy physical exercise program treatment intractable GERD Methods Fifteen participants who underwent upper gastrointestinal endoscopy...