A5031033075- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Inhalation and Respiratory Drug Delivery
- Blood disorders and treatments
- Microfluidic and Capillary Electrophoresis Applications
- Hematopoietic Stem Cell Transplantation
- Cystic Fibrosis Research Advances
- Pluripotent Stem Cells Research
- Anatomy and Medical Technology
- Electrowetting and Microfluidic Technologies
- Additive Manufacturing and 3D Printing Technologies
- Microfluidic and Bio-sensing Technologies
- Cell Image Analysis Techniques
- Air Quality and Health Impacts
- Cancer Cells and Metastasis
- Advanced Materials and Mechanics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced Sensor and Energy Harvesting Materials
- Erythrocyte Function and Pathophysiology
- Acute Myeloid Leukemia Research
- Single-cell and spatial transcriptomics
IMEC
2025
Harvard University
2018-2020
Inspire
2016-2018
Northwestern University
2008
A significant number of lead compounds fail in the pharmaceutical pipeline because animal studies often to predict clinical responses human patients. Human Organ-on-a-Chip (Organ Chip) microfluidic cell culture devices, which provide an experimental vitro platform assess efficacy, toxicity, and pharmacokinetic (PK) profiles humans, may be better predictors therapeutic efficacy safety clinic compared studies. These devices used model function virtually any organ type can fluidically linked...
In this paper, we report on stable liquid-air interfaces and high-aspect-ratio polymer micromembranes with complex controlled structures formed within microfluidic channels. Selective alkanethiol treatment gold copper surfaces is employed to create hydrophilic-hydrophobic boundaries between glass these metal microchannels. Robust interfaces, featured different 3-D structures, are at boundaries. The process for creating highly reproducible. Simulations conducted further study the interfaces....
Here we describe of an ‘Interrogator’ instrument that uses liquid-handling robotics, a custom software package, and integrated mobile microscope to enable automated culture, perfusion, medium addition, fluidic linking, sample collection, in situ microscopic imaging up 10 Organ Chips inside standard tissue culture incubator. The Interrogator platform maintained the viability organ-specific functions 8 different vascularized, 2-channel, (intestine, liver, kidney, heart, lung, skin, blood-brain...
Development of new therapeutics for lung inflammatory and infectious diseases, advancement in our understanding inhalational toxico-pathology have been hindered by challenges to study organ-level complexities human <i>in vitro</i>. Here, we applied a microengineering technological approach known as 9organ-on-chip9 create small airway-on-a-chip that supports full differentiation pseudostratified mucociliary bronchiolar epithelium from normal or diseased donors underlined functional...
Abstract Understanding human bone marrow (BM) pathophysiology in the context of myelotoxic stress induced by drugs, radiation, or genetic mutations is critical importance clinical medicine. However, study these dynamic cellular responses hampered inaccessibility living BM vivo . Here, we describe a vascularized Bone Marrow-on-a-Chip (BM Chip) microfluidic culture device for modeling function and disease states. The Chip comprised fluidic channel filled with fibrin gel which patient-derived...