A5022258522- Advanced Frequency and Time Standards
- Advanced Fiber Laser Technologies
- Cold Atom Physics and Bose-Einstein Condensates
- Protein Structure and Dynamics
- Photonic and Optical Devices
- Machine Learning in Bioinformatics
- Solid State Laser Technologies
- Advanced Chemical Sensor Technologies
- Pulsars and Gravitational Waves Research
- Advanced Measurement and Metrology Techniques
- Analytical Chemistry and Chromatography
- Covalent Organic Framework Applications
- Laser-Matter Interactions and Applications
- Computational Drug Discovery Methods
- RNA and protein synthesis mechanisms
- Atomic and Subatomic Physics Research
- Machine Learning in Materials Science
- Geophysics and Sensor Technology
- SARS-CoV-2 detection and testing
- Machine Learning and Data Classification
- Photonic Crystal and Fiber Optics
- Advanced Neural Network Applications
- Advanced Optical Network Technologies
- Superconducting and THz Device Technology
- Semiconductor materials and interfaces
Beijing Children’s Hospital
2025
Capital Medical University
2025
Physikalisch-Technische Bundesanstalt
2021-2024
Huawei Technologies (China)
2022-2024
China Railway Corporation
2022-2023
Institute of Grassland Research
2023
Chinese Academy of Agricultural Sciences
2023
Ministry of Agriculture and Rural Affairs
2023
Shandong Normal University
2022
Menlo Systems (Germany)
2020-2021
State-of-the-art optical oscillators employing cryogenic reference cavities are limited in performance by the Brownian thermal noise associated with mechanical dissipation of mirror coatings. Recently, crystalline Al 1− x Ga As/GaAs coatings have emerged as a promising candidate for improved coating noise. We present measurements frequency two fully 0.92 0.08 report on birefringent anticorrelated fluctuations between polarization modes and identify variables that affect its magnitude....
Periodontitis is the most prevalent inflammatory disease of periodontium, and related to oral systemic health. Exosomes are emerging as non-invasive biomarker for liquid biopsy. We here evaluated levels programmed death-ligand 1 (PD-L1) mRNA in salivary exosomes from patients with periodontitis non-periodontitis controls. The purposes this study were establish a procedure isolation detection saliva patients, characterize level exosomal PD-L1, illustrate its clinical relevance. Bioinformatics...
In this Perspective we summarize the status of technological development for large-area and low-noise substrate-transferred GaAs/AlGaAs (AlGaAs) crystalline coatings interferometric gravitational-wave (GW) detectors. These topics were originally presented in a workshop{\dag} bringing together members GW community from laser interferometer observatory (LIGO), Virgo, KAGRA collaborations, along with scientists precision optical metrology community, industry partners extensive expertise...
Thermodynamically induced length fluctuations of high-reflectivity mirror coatings put a fundamental limit on sensitivity and stability precision optical interferometers like gravitational-wave detectors ultrastable lasers. The main contribution—Brownian thermal noise—is related to the mechanical loss coating material. Al0.92Ga0.08As/GaAs crystalline are expected reduce this limit. first measurements cryogenic silicon cavities revealed existence additional noise contributions exceeding...
Objective: To analyze the colonization rate and molecular types of Staphylococcus aureus (SA) on tracheotomy wounds neonates at early postoperative stage in neonatal intensive care unit (NICU). Methods: This was a case series study. Patients who were admitted underwent NICU Beijing Children's Hospital, Capital Medical University from January 1st 2020 to December 31st 2023 enrolled. Swabs skin around incision or nasal mucosa collected cultured 24, 72 168 h after operation. Coagulase test...
We report on a transportable and easy-to-operate optical clock utilizing the 2S1/2 - 2D3/2 transition of single trapped 171Yb+ ion at 436 nm. Developed within pilot project for quantum technology in Germany lead by industry, is set up two 19″ racks. In this way, transportation can easily be realized, large degree automatization allows operation outside highly specialized laboratories applications beyond basic research. Comparisons to existing high-accuracy systems enable verification clock's...
Alfalfa Fusarium Root Rot (AFRR) is a serious soil-borne disease with complex pathogenicity. Diseased samples suspected of AFRR were collected from Hohhot, Ordos, Hulunbeier, Chifeng, and Bayannur in Inner Mongolia, China, leading to 317 isolates. The isolates identified as acuminatum, F. solani, equiseti, incarnatum, oxysporum, avenaceum, verticillioides, proliferatum, falciforme, tricinctum, virguliforme, redolens, the results pathogenicity testing showed that 12 species could cause...
Frequency comb synthesized microwaves have been so far realized with tabletop systems, operated in well-controlled environments. Here, we demonstrate state-of-the-art ultrastable microwave synthesis a compact rack-mountable apparatus. We present absolute phase noise characterization of 12 GHz signal using an laser at $\sim{194}\;{\rm THz}$∼194THz and Er:fiber divider, obtaining $ - {83}\;{\rm dBc/Hz}$-83dBc/Hz 1 Hz \lt {166}\;{\rm dBc/Hz}$<-166dBc/Hz for offsets greater than 5 kHz. Employing...
A 1T-CrTe 2 nanoparticle SPF SA-based EDF mode-locking laser with a pulse duration of 586 fs has been obtained for the first time.
Data-driven predictive methods that can efficiently and accurately transform protein sequences into biologically active structures are highly valuable for scientific research medical development. Determining an accurate folding landscape using coevolutionary information is fundamental to the success of modern structure prediction methods. As state art, AlphaFold2 has dramatically raised accuracy without performing explicit analysis. Nevertheless, its performance still shows strong dependence...
We have investigated crystalline AlGaAs/GaAs optical coatings with three ultra-stable cavities operating at 4 K, 16 124 K and 297 K. The response of the resonance frequencies to variations in power indicates effects beyond photo-thermo-optic effect observed dielectric coatings. These are strongly dependent on intensity intracavity light 1.5~\textmu m. When rear side mirrors is illuminated external light, we observe a prominent photo-modified birefringence for photon energies above GaAs...
BK‐type calcium‐activated potassium channels are large conductance that respond to changes in intracellular calcium and membrane potential. These used a wide variety of cell types have recently been linked drug sensitivity tolerance. In both Drosophila mammals, BK encoded by the slowpoke gene. The gene includes 14 alternative exons distributed among five sites splicing. Presumably, purpose processing is provide transcripts tailored needs cell. expressed nervous, muscle epithelial tissues. To...
Proteins are essential component of human life and their structures important for function mechanism analysis. Recent work has shown the potential AI-driven methods protein structure prediction. However, development new models is restricted by lack dataset benchmark training procedure. To best our knowledge, existing open source datasets far less to satisfy needs modern sequence-structure related research. solve this problem, we present first million-level prediction with high coverage...
SummaryWe discovered and characterized a novel birefringent noise in Al<inf>0.92</inf>Ga<inf>0.08</inf>As/GaAs crystalline mirror coatings at cryogenic temperature. We also determined the upper limit of coating Brownian reliable way. Our results indicate that excess related to semiconductor could be an obstacle reaching low thermal floor these coatings. investigations on provide important design considerations for precision interferometry
We present a transportable photonic microwave oscillator, porting optical stability to 10 GHz signal. The system is composed of two main sub-units: compact 8 height-unit (HU) 194 THz ultra-stable laser with Hz linewidth showing fractional frequency (modified Allan deviation) 8.5 × <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-15</sup> at 1 s and 3 HU ultra-low noise comb used phase-coherently divide the reference's spectral purity down...
Predicting drug-target interactions (DTIs) is one of the crucial tasks in drug discovery, but traditional wet-lab experiments are costly and time-consuming. Recently, deep learning has emerged as a promising tool for accelerating DTI prediction due to its powerful performance. However, models trained on limited known data struggle generalize effectively novel pairs. In this work, we propose strategy train an ensemble by capturing both domain-generic domain-specific features (E-DIS) learn...
Abstract We have investigated crystalline AlGaAs/GaAs optical coatings with three ultra-stable cavities operating at 4 K, 16 124 K and 297 K. The response of the cavities’ resonance frequencies to variations in power indicates non-thermal effects beyond photo-thermo-optic effect observed dielectric coatings. These are strongly dependent on intensity intracavity light 1.5 μm. When rear side mirrors is illuminated external light, we observe a prominent photo-modified birefringence for photon...
Thermodynamically induced length fluctuations of high-reflectivity mirror coatings put a fundamental limit on sensitivity and stability precision optical interferometers like gravitational wave detectors ultra-stable lasers. The main contribution - Brownian thermal noise is related to the mechanical loss coating material. Owing their low losses, Al\textsubscript{0.92}Ga\textsubscript{0.08}As/GaAs crystalline are expected reduce this limit. At room temperature they have demonstrated lower...
SummaryWe present a technique to stabilize laser frequency an average of different cavity modes via Pound-Drever-Hall (PDH) scheme. This was applied eliminate the instability arising from fluctuation birefringence in Al<inf>0.92</inf>Ga<inf>0.08</inf>As/GaAs crystalline mirror coatings by locking orthogonally polarized modes.