A5022947439- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Renal Transplantation Outcomes and Treatments
- Chronic Myeloid Leukemia Treatments
- Peroxisome Proliferator-Activated Receptors
- Metabolism and Genetic Disorders
- Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
- Transplantation: Methods and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Bone and Joint Diseases
- T-cell and Retrovirus Studies
- Chronic Lymphocytic Leukemia Research
- Neutropenia and Cancer Infections
- Cytomegalovirus and herpesvirus research
- Hepatitis C virus research
- melanin and skin pigmentation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Plant-Derived Bioactive Compounds
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Antenna Design and Analysis
- Biological Research and Disease Studies
- Parvovirus B19 Infection Studies
- Migraine and Headache Studies
Hospital Israelita Albert Einstein
2010-2020
Universidade Federal de São Paulo
2014-2020
Universidade José do Rosário Vellano
2005
BK polyomavirus reactivation can occur following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and may lead to hemorrhagic cystitis (BKPyV-HC). We hypothesized that development of BKPyV-HC is associated with increased mortality post allo-HSCT.We retrospectively reviewed data on 133 adult patients (≥18 years old) who underwent allo-HSCT from 2007 until 2014 at Hospital Israelita Albert Einstein in São Paulo, Brazil.Thirty-six presented after a median time 42 days, 1-year...
Abstract Busulfan is given in the conditioning regimens preceding hematopoietic stem cell transplantation (HSCT), and plasma levels can be monitored. A targeted, individualized systemic exposure (SE) dose achieved by calculating area under concentration versus time curve (AUC). The objective of this study was to determine a cutoff value for safety AUC busulfan patients undergoing HSCT. total 149 consecutive HSCT were studied. After an oral test busulfan, we set target doses 4000, 5000, or...
Reduced-intensity-conditioned allogeneic stem cell transplantation (SCT) remains a potentially curative approach for patients with relapsed/refractory Hodgkin lymphoma (HL) after an autologous transplantation. In the absence of HLA-identical donor, haploidentical SCT (haplo-SCT) post-transplantation cyclophosphamide (PT-Cy) has been evaluated favorable preliminary results. We 24 who underwent haplo-SCT HL. The conditioning regimen consisted cyclophosphamide, fludarabine, and total body...
Objectives To analyse clinical outcomes comparing two age groups of patients undergoing allogeneic haematopoietic stem cell transplantation (allo-HSCT), and to identify risk factors associated with older patients' mortality. Methods In this retrospective study, the medical charts all consecutive admitted in one hospital for allo-HSCT were reviewed. Overall survival (OS) other compared between aged up 55 years (YG) than (EG). Results From January 2007 August 2014, 111 adult included 75 YG 36...
When studying structural brain connectivity, there are many normalization strategies that can be employed, however, is still no consensus on which one best to use. Hence, in this study, we investigated the impact of normalizing by region volumes context migraine as sometimes done avoid bias towards higher connectivity bigger regions. Several metrics showed significant differences between and, more critically, nodal displayed different behaviours when compared controls and migraineurs.
X-linked adrenoleukodystrophy (X-ALD) is a demyelinating disease caused by the deficiency of ABCD1 gene that encodes for peroxisomal protein membrane. The most severe form X-ALD cerebral variant, which leads to disability and death during first two decades. To date, allogeneic hematopoietic stem cell transplantation (HSCT) only treatment has shown significantly change natural history disease, enhancing survival stabilizing neurological lesions symptoms. In absence matched sibling or...
To analyze the outcome of patients treated with gemtuzumab ozogamycin combined conventional therapy at Hospital Israelita Albert Einstein.14 who had high risk features (secondary leukemia, unfavorable cytogenetics, and refractory disease) were their was analysed by reviewing medical records.Overall response rate 58%, 43% achieving complete response, a median follow-up 11 months, event-free survival 3 months. Eleven died, 6 them due to acute myeloid leukemia. Only four presented grade 4...
Background: Allogeneic stem cell transplantation (allo-HSCT) is a high-cost procedure, mainly represented by length of hospitalization, as well hospital readmissions. Different types alternative donor may impact differently on the costs this procedure. Objective: To evaluate source, type transplant and age at time hospitalization in different allo-HSCT. Method: A retrospective analysis consecutive patients submitted to allo-HSCT our institution from Jan/2010 Jan/2017. Results: 188 were...
IntroductionThe Center for International Blood & Marrow Transplant Research (CIBMTR) presents a system that makes it easier to register standardized transplantation data, as well business intelligence tool the devolution of data transplant centers, Qlikview app, which allows extraction. The software might be useful conduction clinical trials.ObjectiveTo evaluate overall survival (OS) and characteristics patients (pts) undergoing hematopoietic stem cell (HSCT) in Brazil while testing...
To better understand the outcomes of HSCT in Brazil, we conducted a multicenter study using CIBMTR database. Seven participating centers extracted their own data through Data Back to Center tool. Main indications for HSCT-auto were MM(51%), NHL(18%) and HL(17%); Allogeneic, AML(24%), ALL(23%) SAA(15%). For acute leukemias, risk death was higher 18-40 years group (HR=1.18,p=0.022), 40-60(HR=1.19,p<0.001) 60+(HR=1.39,p=0.007), compared with 0-18 years, ALL (HR=1.05,p <0.001, AML)...
Graft-versus-host disease (GvHD) is a major cause of mortality in allogeneic stem cell transplantation (ASCT). This study assessed the distribution and concordance GvHD upper lower gastrointestinal (GI) biopsies its correlation with CMV infection extra-intestinal manifestations GvHD.