A5036285568- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Polyomavirus and related diseases
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Neutropenia and Cancer Infections
- CNS Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Mesenchymal stem cell research
- Organ Donation and Transplantation
- Prenatal Screening and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Cell Function and Interaction
- Venous Thromboembolism Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- Glioma Diagnosis and Treatment
- Science and Education Research
- HIV/AIDS drug development and treatment
- Protein Degradation and Inhibitors
Hospital Israelita Albert Einstein
2016-2024
3E (Belgium)
2017
Fundação Pró-Sangue Hemocentro de São Paulo
2017
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2015-2016
Universidade Federal de São Paulo
2012-2013
Introduction Over the last decades, donor network for hematopoietic cell transplantation (HCT) has grown exponentially, including unrelated and haploidentical (Haplo) donors. This study aimed to describe HCT outcomes with MSD, Haplo, matched donors (MUD) in an early period of Haplo posttransplant cyclophosphamide a developing country large registry. Methods was conducted collaboration CIBMTR. We included patients acute leukemias undergoing between 2014-2018. Results With 595 patients, 2-year...
BK polyomavirus reactivation can occur following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and may lead to hemorrhagic cystitis (BKPyV-HC). We hypothesized that development of BKPyV-HC is associated with increased mortality post allo-HSCT.We retrospectively reviewed data on 133 adult patients (≥18 years old) who underwent allo-HSCT from 2007 until 2014 at Hospital Israelita Albert Einstein in São Paulo, Brazil.Thirty-six presented after a median time 42 days, 1-year...
Abstract Rationale: Lymphomatosis cerebri is a rare form of PCNSL, characterized by diffuse infiltration lymphoma cells in cerebral parenchyma, without mass-formation and mild or no contrast enhancement on magnetic resonance (MR) imaging. There are less than 50 cases described the literature under term cerebri. Patient concerns: A 74-year-old man presented to our service with progressive dementia for 12 months accelerated cognitive decline within last two months. Brain imaging showed areas...
A tromboprofilaxia de rotina, a despeito sua efetividade estar bem estabelecida e o tromboembolismo venoso ser uma condição potencialmente evitável, não se apresenta completamente consolidada na prática clínica. Os objetivos do presente estudo são: 1. Determinar frequência da utilização presença dos fatores risco para tromboembolismo; 2. Verificar adequação em pacientes clínicos internados, assumindo como parâmetro diretriz nacional estabelecida. Estudo retrospectivo transversal envolvendo...
w?>Peripheral blood stem cells (PBSC) are the preferred grafts for hematopoietic cell transplantation (HCT), according to CIBMTR. Donor recovery is faster with PBSC harvest, but associated higher chronic graft-versus-host disease (GVHD) and poorer quality of life. Anti-T-cell globulin (ATG) polyclonal IgG from rabbits or horses immunized human thymocytes a T-cell line, which may reduce GVHD in HCT improve outcomes. The objective this study was analyze impact ATG HLA-matched related (MRD)...
Abstract Few studies have compared the clinical impact of multiple DNA‐virus infections in haploidentical hematopoietic stem cell transplantation (haplo‐HSCT) with posttransplant cyclophosphamide (PTCy) and unrelated donor allogeneic (UD‐HSCT) thymoglobulin, so we retrospectively analyzed viral first 6 mo these scenarios. Fifty‐nine patients underwent to haplo‐HSCT, 68 UD‐HSCT. The most frequent infection was cytomegalovirus (CMV) (76.3% haplo‐HSCT 69.1% UD‐HSCT) ( P = .878) group CMV...
A Embriologia Humana é de extrema importância na formação profissionais saúde, porém seu estudo, muitas vezes, considerado desestimulante, decorativo e sem significado prático para muitos estudantes, tornando-se pouco efetivo. Este trabalho objetivou produzir material didático interativo com modelos embrionários representativos do desenvolvimento embrionário sistema nervoso. Para avaliar forma qualitativa a real efetividade capacidade facilitar o processo ensino-aprendizagem no contexto da...
Splenic diffuse red-pulp small B-cell lymphoma is a rare disease, representing less than 1% of all non-Hodgkin lymphomas (NHL). This entity characterized by involvement bone marrow sinusoids and peripheral blood. The majority cases are at an advanced stage when diagnosed. Its pathogenesis still poorly understood.
Allogeneic stem cell transplantation (HSCT) remains a potentially curative approach for acute lymphoblastic leukemia (ALL), especially high-risk patients and those with relapsed/refractory disease, although its efficacy is offset by not-negligible toxicity. Adult ALL fare worse in developing countries, little data about the HSCT this setting. In study, we aimed to describe outcomes examine risk factors overall survival (OS), leukemia-free (LFS), cumulative incidence of relapse (CIR),...
Reduced-intensity conditioning (RIC) regimens frequently provide insufficient disease control in patients with high-risk hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation (HSCT). We evaluated intensification of fludarabine/busulfan (Flu/Bu) RIC targeted marrow irradiation (TMI) a dose escalation expansion phase I clinical trial. TMI doses were delivered at 1.5 Gy twice daily fractions on days -10 through -7 (dose levels: 3 Gy, 4.5 and 6 Gy), Flu (30 mg/m2...
Routine thromboprophylaxis, despite its well-known effectiveness and the fact that venous thromboembolism is a potentially avoidable condition, not fully established in clinical practice. The objectives of present study were to determine how often thromboprophylaxis used presence risk factors, verify appropriateness use medical inpatients, assuming long-standing national guideline as parameter. This was retrospective cross-sectional study, involving inpatients with conditions adult general...
Abstract Introduction Triple‐ and quad‐refractory multiple myeloma patients usually have an aggressive course a poor prognosis. Available therapeutic options are scarce. Methods The objective of the current study was to evaluate responses toxicities VDTPACE or mCBAD with hematopoietic stem‐cell support as bridge subsequent therapies in refractory/relapsed myeloma. Results Thirteen were included (11 mCBAD, 2 VDTPACE), 21 cycles chemotherapy delivered. Mean number previous 4.8. Stem cells...
Post-transplant cyclophosphamide has contributed to the success of haploidentical hematopoietic stem cell transplantation (HSCT) and is also been used in from matched donors. However, limited data on immune reconstitution after this type immunosuppression available. We aimed evaluate HSCT unrelated donors, comparing anti-thymocyte globulin (ATG) post-transplant (PTCy). Consecutive patients undergoing donors receiving either ATG or PTCy were prospectively included. Immune analyses performed...