A5088416889- Nuclear Receptors and Signaling
- Cytokine Signaling Pathways and Interactions
- Animal Behavior and Reproduction
- Reproductive biology and impacts on aquatic species
- Parkinson's Disease Mechanisms and Treatments
- Zebrafish Biomedical Research Applications
- Autism Spectrum Disorder Research
- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- Reproductive System and Pregnancy
- RNA Research and Splicing
- Lipid Membrane Structure and Behavior
- ATP Synthase and ATPases Research
- CRISPR and Genetic Engineering
- Vitamin D Research Studies
- Genetics and Neurodevelopmental Disorders
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
University of Padua
2022-2024
Abstract Dopamine dyshomeostasis has been acknowledged among the determinants of nigrostriatal neuron degeneration in Parkinson’s disease (PD). Several studies experimental models and postmortem PD patients underlined increasing levels dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL), which is highly reactive towards proteins. DOPAL shown to covalently modify presynaptic protein αSynuclein (αSyn), whose misfolding aggregation represent a major trait pathology, triggering αSyn...
Glucocorticoids mainly exert their biological functions through cognate receptor, encoded by the
Abstract Background AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. The zebrafish genome contains two ambra1 paralogous genes ( b ), both involved in development expressed at high levels the gonads. Characterization of mutant lines generated CRISPR/Cas9 approach showed that ambra1b knockout leads all-male population....
Glucocorticoids (GCs) have a wide spectrum of effects on animal behavior. A recently suggested effect involves determining the structure individual differences, that is how behavioral traits an covary, forming so-called syndromes. As GCs can exert their action in multiple ways, e.g., via rapid non-genomic or activation two highly homologous members steroid receptor family acting as transcription factors, it unclear GC modulation syndromes takes place. We exploited zebrafish line with...
Stat3 is a transcription factor with key role in cell proliferation and migration. Using the
A β-glucosyl sterol probe bearing a terminal alkyne moiety for fluorescent tagging enables the investigation of neuronal and intracellular localization this class compounds involved in neurodegenerative diseases. The compound showed cells, with marked differences uptake metabolism leading to enhanced persistence respect un-glycosylated analogue. In addition, different impact was observed towards lysosomes, simple showing enlargement lysosome structures, while less capable alter morphology...