A5048114470- RNA Research and Splicing
- Medical and Biological Ozone Research
- Pluripotent Stem Cells Research
- Pancreatic function and diabetes
- Cannabis and Cannabinoid Research
- CRISPR and Genetic Engineering
- Zebrafish Biomedical Research Applications
- Therapeutic Uses of Natural Elements
- Cardiomyopathy and Myosin Studies
- Genetics and Physical Performance
- Cardiovascular Effects of Exercise
University of Padua
2022-2024
The Euganean Thermal District, situated in North-East Italy, is one of Europe’s largest and oldest thermal centres. topical application its therapeutic muds recognised by the Italian Health System as a beneficial treatment for patients suffering from arthro-rheumatic diseases. Polysaccharides produced mud microbiota have been recently identified anti-inflammatory bioactive molecules. In this paper we analysed efficacy Microbial-Polysaccharides (M-PS) derived mature obtained at different...
Abstract Colon cancer is one of the leading causes death worldwide. In recent years, cannabinoids have been extensively studied for their potential anticancer effects and symptom management. Several in vitro studies reported anandamide’s (AEA) ability to block cell proliferation migration, but evidence from vivo still lacking. Thus, this study, AEA exposure zebrafish embryos transplanted with HCT116 cells were evaluated. Totally, 48 hpf xenografts exposed 10 nM AEA, AM251, cannabinoid 1...
Abstract Background AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. The zebrafish genome contains two ambra1 paralogous genes ( b ), both involved in development expressed at high levels the gonads. Characterization of mutant lines generated CRISPR/Cas9 approach showed that ambra1b knockout leads all-male population....
Arrhythmogenic cardiomyopathy (AC) is an inherited disorder characterized by progressive loss of the ventricular myocardium causing life-threatening arrhythmias, syncope and sudden cardiac death in young athletes. About 40% AC cases carry one or more mutations genes encoding for desmosomal proteins, including Desmoplakin (Dsp). We present here first stable Dsp knock-out (KO) zebrafish line able to model alterations cell signalling dysregulation, characteristic disease, on which environmental...