A5058216458- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammatory Bowel Disease
- Diverticular Disease and Complications
- Genetic factors in colorectal cancer
- Anorectal Disease Treatments and Outcomes
- Global Health and Surgery
- Colorectal Cancer Treatments and Studies
- COVID-19 and healthcare impacts
- Pelvic floor disorders treatments
- Pancreatic and Hepatic Oncology Research
- Diversity and Career in Medicine
- Innovations in Medical Education
- Colorectal and Anal Carcinomas
- Gastrointestinal disorders and treatments
- Thyroid Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Pelvic and Acetabular Injuries
- Gallbladder and Bile Duct Disorders
- Cancer, Lipids, and Metabolism
- Stoma care and complications
- Intestinal and Peritoneal Adhesions
- Microscopic Colitis
- Lung Cancer Treatments and Mutations
University of Kelaniya
2015-2025
Colombo North Teaching Hospital
2011-2025
Imperial College London
2016-2025
University of Peradeniya
2024
Health Affairs
2024
St Mark's Hospital
2016-2020
University of London
2017
Abstract Background The Covid-19 pandemic necessitated the delivery of online higher education. Online learning is a novel experience for medical education in Sri Lanka. A approach to undergraduate surgical was taken up an attempt improve interest amongst students clinical practice while maximizing limited contact time. Method activity designed involving from all stages and multi consultant panel discussions. discussions were cover each topic basic sciences high-level management stimulate...
Serum albumin is a marker of nutrition and inflammation. It has recently emerged as predictor outcome after surgery for rectal cancer. Our aim was to evaluate if pre-operative serum would predict survival resection cancer.226 Patients with cancer all stages undergoing curative intent were studied. Kaplan-Meier curves analysed based on level <35 g/L vs. >35 g/L. We sought significant associations age, sex, stage, tumour site, use neoadjuvant chemoradiation, microscopic positive margins,...
The transanal approach to ileal pouch-anal anastomosis [Ta-IPAA] provides better access the lower pelvis with short-term morbidity in ulcerative colitis [UC]. aim of this study was assess long-term functional outcomes after Ta-IPAA vs transabdominal IPAA [Abd-IPAA] UC.A multicentre cohort analysis performed between March 2002 and September 2017. Patient characteristics, surgical details postoperative were compared. CGQL [Cleveland global quality life] score at 12 months a functioning pouch...
Introduction: Colorectal cancer (CRC) is the third most prevalent in Sri Lanka, with rising incidence rates over past decade. Timely intervention essential for favourable outcomes, but prolonged waiting times remain a significant healthcare challenge globally. This study examines time intervals between key steps CRC diagnostic and treatment pathway to identify potential areas reducing delays.Methods: A cohort of 108 patients suspected symptoms, presenting University Surgical Unit at North...
Understanding how life-history strategies influence cancer susceptibility in dinosaurs requires a molecular-level analysis of preserved soft tissues. While previous research has largely focused on skeletal remains, the discovery tissue structures fossils, such as Telmatosaurus transsylvanicus, highlights need for new approach. Paleoproteomics offers transformative opportunity to analyze ancient proteins, revealing evolutionary trade-offs between growth, reproduction, and suppression. This...
Familial Adenomatous Polyposis (FAP) is an autosomal dominant condition giving rise to multiple adenomatous polyps in the colon which invariably become malignant by fourth decade. Congenital hypertrophy of retinal pigment epithelium (CHRPE) one its extra intestinal manifestations early childhood seen, present 90% FAP population and easy detect.Patients diagnosed with at risk first degree family members were screened for CHRPE using a slit lamp indirect ophthalmoscopy. The retina 17 patients...
Abstract Background Duke Activity Status Index (DASI) is a widely used tool to assess functional capacity among patients, but there no Sinhala version validated for patients in Sri Lanka. This study aimed cross-culturally adapt and test the validity reliability of DASI (DASI-S). Methods The translation cross-cultural adaptation questionnaire were conducted following standard guidelines. It was pre-tested on ten pre-operative further modified. construct DASI-S evaluated by administering...
CORRECTION: The spelling of the second author's name was changed from PC Chandrasinge to Chandrasinghe on 22/04/2013.Introduction Sri Lanka is endemic for goiters. Iodine deficiency thought be main cause. global iodisation programme implemented in country 1995. Several studies done school children have shown a reduction goiter prevalence (3.8%) initial post period. An island wide, community based study carried out Methods A multistage cluster sampling method used. Examination goiters by two...
Since total mesorectal excision (TME) was first described in the early 1930s and later popularised by Heald [1], efforts have been made to standardise technique, following correct embryological planes using appropriate landmarks. Laparoscopic robotically assisted approaches rectum gained popularity during recent years, compelling colorectal surgeons develop their skills knowledge. Transanal TME (TaTME) is a new addition rectal surgery. Despite being associated with several benefits selected...
We evaluated the effect of tailoring treatments based on predictions informed by tumor molecular profiles across a range cancers, using data from Caris Life Sciences. These included breast carcinoma, colorectal adenocarcinoma, female genital tract malignancy, lung non-small cell cancer, neuroendocrine tumors, ovarian surface epithelial carcinomas, and urinary cancers. Molecular mostly immunohistochemistry (IHC) DNA sequencing for tumors 841 patients had been previously used to recommend...
Mucinous cystadenoma of the liver is a rare (less than 5%) neoplasm. This condition more common in young women and accounts for non-specific symptoms. Cyst adenomas commonly affect intrahepatic system (90%) are rarely found extrahepatic biliary or affecting both systems.A 39-year-old Sinhalese woman presented with features obstructive jaundice was to have neoplasm on imaging. In absence definitive diagnosis despite extensive imaging she underwent preoperative endoscopic drainage followed by...
Colorectal cancer (CRC) burden is increasing in the south Asian region due to changing socio-economic landscape and population demographics. There a lack of robust high quality data from this order evaluate disease pattern comparison. Using generalized linear models assuming Poisson distribution model fitting, authors describe variation CRC along time since 1997 at regional tertiary care center Sri Lanka.Analyzing 679 patients, it observed that both colon rectal cancers have significantly...
Abstract Background Pre-operative long-course chemoradiotherapy (CRT) for rectal cancer has resulted in improvement rates of restorative resection and local recurrence by inducing tumour downstaging downsizing. Total mesorectal excision (TME) is a standardised surgical technique low anterior aimed at the prevention recurrence. The purpose this study was to evaluate response following CRT group patients with cancer. Methods One hundred thirty-one (79 male; 52 female, median age 57;...
Introduction . There has been a continuous debate on whether elderly patients with colorectal cancer (CRC) fair worse. The aim of this study is to assess the thirty-day mortality (TDM) and overall survival (OS) undergoing surgery for CRC. Method OS between two groups (≥70 versus <70 years) having CRC was analyzed. Demographics, tumour characteristics, serological markers were considered as independent factors. Multivariable analysis done using Cox proportional hazard model. We also...
ABSTRACT Introduction Total thyroidectomy is considered as the standard surgical procedure for most malignancies and benign disease involving both lobes of thyroid gland. Postoperative complications are likely to be commoner when gland large in size due alteration structural anatomy. Methods 102 patients who underwent total disease, by same surgeon, were analyzed. Patients prospectively followed up presence hoarseness hypocalcemia, transient temporary, compared with weight Results Fourteen...
Single port laparoscopic surgery (SPLS) is a technique which increasing in popularity. The benefit of SPLS complex Crohn's disease (CD), includes significant cohort young patients sometimes needing multiple operations, has not been comprehensively assessed. This study analyses our early experience with this technique.Patients who underwent for CD were included. Data collected prospectively from January 2013 to December 2015. Ileocolic resections, right hemicolectomy, small bowel...
// Philip Carter 1 , Costi Alifrangis 2 Biancastella Cereser Pramodh Chandrasinghe 1, 3 Lisa Del Bel Belluz Nina Moderau Fotini Poyia Lee S. Schwartzberg 4 Neha Tabassum Jinrui Wen Jonathan Krell and Justin Stebbing Department of Surgery Cancer, Imperial College, London, UK Oncology, University College Hospital, Surgery, Kelaniya, Sri Lanka West Cancer Center, The Tennessee, Memphis, USA Correspondence to: Carter, email: phil.carter@imperial.ac.uk Keywords: tumor profiling; breast cancer;...
Ileal perforation due to fish bone is a rare event. The condition difficult diagnose lack of specific clinical features and low sensitivity imaging techniques. We report case ileal by that was detected laparoscopically managed nonsurgically.A 45-year-old Sinhalese man presented with acute onset right iliac fossa pain fever for three days. On examination, he had significant tenderness guarding. His white cell count C-reactive protein level were elevated an ultrasound scan indicative bowel...