A5067098032- Polymer Surface Interaction Studies
- Orthopedic Infections and Treatments
- Bone Tissue Engineering Materials
- Dendrimers and Hyperbranched Polymers
- Dental materials and restorations
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Bacterial biofilms and quorum sensing
- Platelet Disorders and Treatments
- Glycosylation and Glycoproteins Research
- Vascular Procedures and Complications
- Marine Biology and Environmental Chemistry
- Orthopaedic implants and arthroplasty
- Proteoglycans and glycosaminoglycans research
- Dental Implant Techniques and Outcomes
- Pancreatic function and diabetes
- Coronary Interventions and Diagnostics
- Peripheral Artery Disease Management
- Periodontal Regeneration and Treatments
- Cellular Mechanics and Interactions
- Silk-based biomaterials and applications
- Microfluidic and Bio-sensing Technologies
University of South Australia
2017-2024
South Australia Pathology
2022
South Australian Health and Medical Research Institute
2022
Centre for Cancer Biology
2022
Monash University
2017
Australian Regenerative Medicine Institute
2017
The University of Adelaide
2017
Inspired by observations that the natural topography observed on cicada and dragonfly wings may be lethal to bacteria, researchers have sought reproduce these nanostructures biomaterials with goal of reducing implant-associated infections. Titanium its alloys are widely employed excellent properties but susceptible bacterial colonisation. Hydrothermal etching is a simple, cost-effective procedure which fabricates nanoscale protrusions various dimensions upon titanium, depending parameters...
The demand for joint replacement and other orthopedic surgeries involving titanium implants is continuously increasing; however, 1%-2% of result in costly devastating implant associated infections (IAIs). Pseudomonas aeruginosa Staphylococcus aureus are two common pathogens known to colonise implants, leading serious complications. Bioinspired surfaces with spike-like nanotopography have previously been shown kill bacteria upon contact; the longer-term potential such prevent or delay biofilm...
The demand for medical implants globally has increased significantly due to an aging population amongst other reasons. Despite the overall increase in survivorship of Ti6Al4V implants, implant infection rates are increasing factors such as diabetes, obesity, and bacterial resistance antibiotics. Two commonly found bacteria implicated infections Staphylococcus aureus Pseudomonas aeruginosa. Based on prior work that showed nanostructured surfaces might have potential passively killing these...
The present study interrogates the interaction of highly efficient antibacterial surfaces containing sharp nanostructures with blood proteins and subsequent immunological consequences, processes that are key importance for fate every implantable biomaterial. Studies human serum plasma pointed to significant differences in composition protein corona formed on control nanostructured surfaces. Quantitative analysis using liquid chromatography-mass spectrometry demonstrated surface attracted...
Cell aggregates reproduce many features of the natural architecture functional tissues, and have therefore become an important <italic>in vitro</italic> model tissue function.
Hyperbranched polyglycerol (HPG) was previously investigated as a nonfouling hydrophilic grafted layer on biomaterial surfaces, analogous to the well-known poly(ethylene oxide) (PEO), but range of adsorbing cells and proteins tested limited at times assays used were not most sensitive. Thus, questions arise whether HPG-grafted layers can indeed efficiently resist adsorption wider biological entities, how would different entities interact with such coating. An HPG coating 25 nm thickness onto...
While blood-contacting materials are widely deployed in medicine vascular stents, catheters, and cannulas, devices fail situ because of thrombosis restenosis. Furthermore, microbial attachment biofilm formation is not an uncommon problem for medical devices. Even incremental improvements hemocompatible can provide significant benefits patients terms safety patency as well substantial cost savings. Herein, a novel but simple strategy described coating range materials, that be applied to...
Abstract Background A nanostructured titanium surface that promotes antimicrobial activity and osseointegration would provide the opportunity to create medical implants can prevent orthopaedic infection improve bone integration. Although surfaces exhibit activity, it is not known whether these are safe conducive osseointegration. Questions/purposes Using a sheep animal model, we sought determine bony integration of medical-grade, titanium, porous-coated with unique modification (alkaline...
The propensity of glycosaminoglycans to mediate cell-cell and cell-matrix interactions opens the door capture cells, including circulating blood onto biomaterial substrates. Chondroitin sulfate (CS)-B is particular interest, since it interacts with receptor (EGF)-like module-containing mucin-like hormone receptor-like 2 precursor (EMR2) displayed on surface leukocytes endothelial progenitor cells. Herein, CS-B its isomer CS-A were covalently immobilized heptylamine plasma polymer films via...
PolyJet three-dimensional (3D) printing allows for the rapid manufacturing of 3D moulds fabrication cross-linked poly(dimethylsiloxane) microwell arrays (PMAs). As this technique has a resolution on micrometer scale, exhibit distinct surface roughness. In study, authors demonstrate by optical profilometry that topography printed can be transferred to PMAs and roughness induced cell adhesive properties material. particular, facilitated immobilization endothelial cells internal walls...
Cardiovascular disease is a leading cause of death worldwide; however, despite substantial advances in medical device surface modifications, no synthetic coatings have so far matched the native endothelium as optimal hemocompatible for blood-contacting implants. A promising strategy rapid restoration on biomedical devices entails attracting circulating endothelial cells or their progenitors, via immobilized cell-capture molecules; example, anti-CD34 antibody to attract CD34+ colony-forming...
Abstract Synthetic materials with an innate ability to avoid the foreign-body-response remain unrealized goal that would transform medical device industry. The balance of bulk material properties, enable a perform as intended, surface provide bio- and hemocompatibility, has always required former be prioritized. While all used in modern devices have acceptable level biocompatibility, imperfection remains, ultimately leading failure, or requiring pharmacological intervention for it tolerated....