A5101901411- Metabolism and Genetic Disorders
- Neonatal Health and Biochemistry
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- Folate and B Vitamins Research
- Muscle Physiology and Disorders
- RNA modifications and cancer
- Amino Acid Enzymes and Metabolism
- Insect Resistance and Genetics
- Toxoplasma gondii Research Studies
- Prenatal Screening and Diagnostics
- bioluminescence and chemiluminescence research
- Genomics and Rare Diseases
- Epigenetics and DNA Methylation
- Biochemical and Molecular Research
- Photoreceptor and optogenetics research
- RNA Interference and Gene Delivery
- Lysosomal Storage Disorders Research
- Cancer Research and Treatments
- Genomic variations and chromosomal abnormalities
- Cancer Genomics and Diagnostics
- Zebrafish Biomedical Research Applications
- Cancer-related gene regulation
- Single-cell and spatial transcriptomics
- Fermentation and Sensory Analysis
Nanjing Maternity and Child Health Care Hospital
2016-2025
Nanjing Medical University
2016-2025
Leshan Normal University
2008-2025
West China Second University Hospital of Sichuan University
2023-2025
Women's Hospital
2024
Jinzhou Medical University
2021-2023
Zunyi Medical University
2023
Sichuan University
2023
South China Agricultural University
2022
Chongqing University
2022
Non-small cell lung cancer (NSCLC) represents one of the primary causes cancer-related mortality all over world. Following our initial finding upregulated expression E2F transcription factor-1 (E2F1) in NSCLC-related microarray, this study aimed to explore regulatory role E2F1 and underlying mechanism NSCLC development. viability, migration, invasion were evaluated utilizing Cell Counting Kit 8 (CCK-8), 5-ethynyl-2′-deoxyuridine (EdU), wound-healing, Transwell assays. Loss- gain-function...
Embryonic stem cells (ESCs) can be induced to differentiate into nerve cells, endowing them with potential applications in the treatment of neurological diseases and neural repair. In this work, we report for first time that sulfated chitosan promote differentiation ESCs. As a type glycosaminoglycan analog, well-defined sulfation sites controlled degree (DS) were prepared through simple procedures influence on ESCs was investigated. Compared other sites, 6-O-sulfated showed most optimal...
Abstract Background Ornithine transcarbamylase deficiency exhibits a high degree of clinical heterogeneity, making its screening and classification challenging in some instances. In this study, we first established simple stable method for testing ornithine activity using micro blood from newborns, rather than relying on venous blood. Methods The was assessed by measuring the concentration citrulline produced reaction with carbamoyl phosphate ornithine, serum, plasma or Correlation analysis...
The consumption of stinky tofu, a traditional fermented soybean product from China, elevates the concentrations indole and trimethylindole in murine feces increases levels serum, as well liver. These hepatic compounds act ligands for Aryl Hydrocarbon Receptor (AHR), triggering activation this receptor, which subsequently enhances expression enzyme cytochrome P450 (CYP) 1A1. This upregulation diminishes pro-inflammatory cytokines, thereby attenuating alcohol-induced liver injury. study...
It is well known that adsorbed proteins play a major role in cell adhesion. However, it has also been reported cells can adhere to protein-resistant surface. In this work, the behavior of L02 and BEL-7402 on protein-resistant, 3D topographical surface was investigated. The gold nanoparticle layer (GNPL) surfaces were prepared by chemical plating, topography described roughness parameters acquired from multiscale analysis. Both smooth Au GNPL modified with POEGMA polymer brushes using...
Abstract Methuselah ( M th) is associated with lifespan, stress resistance and reproduction in D rosophila melanogaster , but Mth not present nondrosophiline insects. A number of methuselah‐likes mthls ) have been identified insects, it unknown whether the functions mth are shared by or divergent from them. Five T ribolium castaneum . Although they different developmental expression patterns, all enhance to starvation. Only mthl1 mthl2 high temperature, whereas mthl4 mthl5 negatively...
Background MicroRNAs are now recognized as key post-transcriptional regulators in animal ontogenesis and phenotypic diversity. Eupolyphaga sinensis Walker (Blattaria) is a sexually dimorphic insect, which also an important source of material used traditional Chinese medicine. The male E. have shorter lifecycles go through fewer instars than the female. Furthermore, males forewings, while females totally wingless. Results We Illumina/Solexa deep sequencing technology to sequence small RNA...
Hydrogen sulfide (H2S) is accepted as a third "gasotransmitter'' of human physiology and pathology but remains difficult to study, in large part because the lack methods for selective monitoring this small signaling molecule live biological specimens. We now report new reaction-based polymeric fluorescent sensor imaging H2S living cells. A novel functional monomer, 2-allyl-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinoline-6-sulfonyl azide (AISA) was firstly synthesized copolymerized with...
The Creeper trait, a classical monogenic phenotype of chicken, is controlled by dominant semi-lethal gene. This trait has been widely cited in the genetics and molecular biology textbooks for illustrating autosomal inheritance over decades. However, genetic basis remains unknown. Here we have utilized ultra-deep sequencing extensive analysis targeting causative mutation controlling trait. Our results indicated that deletion Indian hedgehog (IHH) gene was only found whole-genome data lethal...
A untargeted metabolomics approach was proposed in this study based on ultra-high performance liquid chromatography quadrupole time-of-flight (UHPLC-QTOF) and rapid evaporative ionization mass spectrometry (REIMS) to discriminate lamb mutton meat investigate their subtle metabolic differences, considering the higher popularity of than market. Multivariate statistical analysis performed for data processing order distinguish between two sample types. total 42 potential metabolites (20 positive...
Abstract Background Hyperphenylalaninemia (HPA) is the most common amino acid metabolic disease involving phenylalanine hydroxylase (PAH, OMIM*612,349) deficiency or coenzyme tetrahydrobiopterin (BH4) deficiency. Patients with severe HPA often have a difficult life. Early diagnosis of before development symptoms possible via neonatal screening, facilitating appropriate treatment and reducing mortality disability rates. This study revealed prevalence, mutational phenotypic spectrum, prognosis...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic excitation transfer in the complex of lumazine protein with bacterial bioluminescence intermediatesJohn Lee, Yanyun Wang, and Bruce G. GibsonCite this: Biochemistry 1991, 30, 28, 6825–6835Publication Date (Print):July 16, 1991Publication History Published online1 May 2002Published inissue 16 July 1991https://pubs.acs.org/doi/10.1021/bi00242a004https://doi.org/10.1021/bi00242a004research-articleACS PublicationsRequest reuse...
Duchenne muscular dystrophy is the most common genetic muscle disease. Affected muscles are characterized by abnormal acetylcholine receptor (AChR) clustering. Some studies have suggested that changes in AChR clusters secondary to degenerative processes. In this study, we demonstrate cluster fragmentation and degeneration separate events. We compared pathological features mdx mice (mutated dystrophin) dko dystrophin utrophin). were identified binding with α-bungarotoxin, observed classical...
The objective of the study was to investigate clinical and gene mutation characteristics primary carnitine deficiency (PCD) patients identified by newborn screening using tandem mass spectrometry (MS/MS).Tandem (MS/MS) applied screen inherited metabolic disease seven with PCD were diagnosed among 62,568 samples. SLC22A5 detected diagnosis panel genetic diseases based on Ion Torrent Semiconductor Sequencing Technology.The initial free (C0) concentrations 6.43±1.36 μmol/L, recall 5.59±0.89...