A5101715498- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Gastric Cancer Management and Outcomes
- Estrogen and related hormone effects
- Clostridium difficile and Clostridium perfringens research
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Gastrointestinal motility and disorders
- TGF-β signaling in diseases
- Inflammasome and immune disorders
- Probiotics and Fermented Foods
- Digestive system and related health
- Inflammatory mediators and NSAID effects
- Drug Transport and Resistance Mechanisms
- Hormonal Regulation and Hypertension
- Infant Nutrition and Health
- Sperm and Testicular Function
- Endometrial and Cervical Cancer Treatments
- Cancer, Lipids, and Metabolism
- Dietary Effects on Health
- Glutathione Transferases and Polymorphisms
- Immune Cell Function and Interaction
Seoul National University Bundang Hospital
2019-2025
Seonam University
2023
This study aimed to establish an organoid culture model using small intestine tissues from male and female C57BL/6 mice compare it with rat cultures derived frozen tissues. Crypts were isolated the intestines of eight-week-old cultured in 3D extracellular matrix Wnt, R-spondin, Noggin. In addition, sixteen-week-old F344 rats preserved a storage solution immediately post-sacrifice stored at -80°C before being transferred nitrogen tank. Upon thawing, crypts failed develop into organoids due...
Sex hormones affect development and prognosis of gastric cancer (GC). This study aimed to compare the sex hormone receptor expression between control GC, evaluate its correlation with patient characteristics. 110 patients (74 36 controls) underwent immunohistochemistry (IHC) reverse transcription-polymerase chain reaction (RT-PCR) for estrogen receptors (ERs) α β androgen (AR). The effect ERs AR on clinicopathological tumor characteristics were analyzed. positive rate ERα, ERβ, in GC tissue...
Gut microbiota is closely associated with development and exacerbation of inflammatory bowel diseases (IBD). The aim this study was to investigate differences in gut depending on sex changes during IBD developments.16s rRNA metagenomic sequencing performed for fecal materials from 8-week-old wild type (WT) interleukin 10 (IL-10) knockout (KO) C57BL/6 mice both sexes. Diversity indices, relative abundance microbiota, linear discriminant analysis effect size were examined compare microbial...
: The gut microbiome has emerged as a key player that mechanistically links various risk factors to colorectal cancer (CRC) etiology. However, the role of in CRC pathogenesis remains unclear. This study aimed characterize microbiota healthy controls (HCs) and patients with adenoma (AD) subgroups based on sex age.
Sex hormones are known to affect the gut microbiota. Previously, we reported that endogenous and exogenous testosterone associated with colorectal cancer (CRC) development submucosal invasion. In present study, investigated whether microbiota is affected by orchiectomy (ORX) propionate (TP) administration using an azoxymethane/dextran sulfate sodium (AOM/DSS)-induced CRC mouse model.Gut was evaluated means of 16S rRNA gene sequencing stool DNA extracted from feces were obtained at 13 weeks...
Background The incidence and mortality rates of colorectal cancer (CRC) has been reported to be strongly associated sex/gender difference. CRC shows sexual dimorphism, sex hormones have shown affect the tumor immune microenvironment. This study aimed investigate location-dependent differences in tumorigenic molecular characteristics patients with tumors, including adenoma CRC. Methods A total 231 participants, 138 CRC, 55 adenoma, 38 healthy controls, were recruited between 2015 2021 at...
17β-Estradiol (E2) supplementation suppresses MC38 tumor growth by downregulating the expression of programmed death-ligand 1 (PD-L1). This study aims to figure out gut microbiota that respond anti-PD-L1 and/or estrogen treatment in colon cancer model.A syngeneic model was developed injection cells into C57BL/6 background male and female mice. Three days before injection, E2 supplemented mice daily for week. Male with tumors (50-100 mm3) were injected antibody. Fresh feces collected 26 after...
Tight junction proteins (TJPs) play a role in epithelial defense mechanisms. However, the effect of Helicobacter pylori (Hp) on TJPs remains unclear. This study aimed to evaluate expression relation Hp infection and eradication gastric carcinogenesis.In total, 510 subjects (284 controls 226 cancer [GC] patients) were prospectively enrolled study. The claudin-1 -2 (CLDN-1, -2), occludin (OCLN), tight protein 1 (TJP1) was measured based their status normal corpus mucosa evaluated following...
β-Casein, a major protein in cow's milk, is divided into the A1 and A2 type variants.Digestion of β-casein yields peptide β-casomorphin-7 which could cause gastrointestinal (GI) discomfort but milk containing only might be more beneficial than A1/A2 (regular) milk.The aim this study was to evaluate differences GI after ingestion milk.A randomized, double-blind, cross-over human trial performed with 40 subjects who experienced following consumption.For each intervention period, either first...
Abstract This study investigated the role of Ninjurin1 ( Ninj1 ), encoding a small transmembrane protein, in colitis‐associated colon tumorigenesis relation to sex hormones. Male and female wild‐type (WT) knockout (KO) mice were treated with azoxymethane (AOM) dextran sulfate sodium (DSS), or without testosterone propionate (TP). At week 2 (acute colitis stage), KO exhibited an alleviation symptoms both male mice. The M2 macrophage population increased CD8 + T cell decreased only than WT...
Colon tumors develop more frequently in male than female.Nuclear factor erythroid 2-related 2 (Nrf2) plays differential roles the stage of tumorigenesis.The purpose this study was to investigate role Nrf2 on colitis-associated tumorigenesis using knockout (KO) female mice.Azoxymethane (AOM) and dextran sulfate sodium (DSS)-treated wild-type (WT) KO mice were sacrificed at week 16 after AOM injection.Severity colitis, tumor incidence, levels inflammatory mediators evaluated AOM/DSS-treated WT...
The gut microbiota interacts with the host environment, which is influenced by such factors as sex, age, and diet.These induce changes in microbial composition.The aim of this study was to identify differences microbiome Fisher-344 (F344) rats fed a high-fat diet (HFD), depending on their age sex.Fecal microbiomes from 6-, 31-, 74-week-old, 2-year-old both male female (corresponding 5-, 30-, 60-, 80-year-old humans) were analyzed using 16S rRNA gene sequencing, phylogenetic investigation...