A5080608393- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Immune Response and Inflammation
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Traumatic Brain Injury and Neurovascular Disturbances
- Genomics, phytochemicals, and oxidative stress
- Oral microbiology and periodontitis research
- NF-κB Signaling Pathways
- Vascular Malformations Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Aldose Reductase and Taurine
- Cerebral Venous Sinus Thrombosis
- Flavonoids in Medical Research
- Angiogenesis and VEGF in Cancer
- Anesthesia and Sedative Agents
- Spinal Fractures and Fixation Techniques
- Peripheral Artery Disease Management
- Pharmacological Effects and Toxicity Studies
- Head and Neck Surgical Oncology
- Fatty Acid Research and Health
- Heme Oxygenase-1 and Carbon Monoxide
- Pituitary Gland Disorders and Treatments
- Biological Activity of Diterpenoids and Biflavonoids
Hexi University
2024
Nantong University
2021-2023
Taizhou People's Hospital
2021-2023
Dalian Medical University
2021
Nanjing Medical University
2010-2016
Wuxi People's Hospital
2012-2016
Wuxi No.2 People's Hospital
2016
Xian Yang Central Hospital
2012
Nanjing General Hospital of Nanjing Military Command
2007-2009
Nanjing University
2007-2009
Previous studies have shown that nuclear factor erythroid 2-related 2 (Nrf2) plays a unique role in many physiological stress processes. The present study investigated the of Nrf2 modulating traumatic brain injury (TBI)-induced secondary injury. Wild-type (+/+) and (-/-)-deficient mice were subjected to moderately severe weight-drop impact head absence function resulted exacerbated as by increased severity neurological deficit, apoptosis, edema at 24h after TBI. This exacerbation...
Alterations of the host response caused by short-term exposure to high levels smoke during act smoking (acute exposure) as well long-term lower tobacco substances in bloodstream smokers (chronic may play a role pathogenesis periodontal diseases smokers. In this study, we examined secretion three cytokines [interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and transforming growth (TGF)-beta] from mononuclear blood cells current non-smokers exposed vitro (which be comparable vivo...
Interleukin-33 (IL-33) has shown diagnostic and prognostic values in multiple human cancers. However, there is little knowledge on the role of IL-33 gliomas its association with disease prognosis. This study aimed to evaluate value prognosis glioma patients. The expression was determined compared surgical specimens from 86 patients 16 normal brain tissues. associations clinicopathological features were assessed. qRT-PCR assay showed higher mRNA tissues than tissue ( p < 0.001), significantly...
We have previously shown that traumatic brain injury (TBI) can induce an upregulation of nuclear factor kappa B (NF-kappaB) and proinflammatory cytokines in the gut, which play important role pathogenesis acute gut mucosal mediated by inflammation. In this work, we investigated whether progesterone administration modulated intestinal NF-kappaB activity expression after TBI male rats. As a result, found following could decrease binding activity, p65 protein expression, concentrations...
Background: Secondary brain damage plays a critical role in the outcome of patients with traumatic injury (TBI). The mechanisms underlying secondary are complex. A target that can interrupt multiple may represent promising new therapeutic approach for TBI. NF-E2-related factor 2 (Nrf2) is key regulator reducing oxidative stress, inflammatory damage, and accumulation toxic metabolites, which all involved after Therefore, Nrf2 might direction treatment However, expression pattern TBI has not...
The effects of interleukin-10 (IL-10) and glucose on mRNA protein expression osteoprotegerin (OPG), its ligand, receptor activator nuclear factor-κB ligand (RANKL), were investigated in human periodontal ligament fibroblasts (HPDLFs). Primary HPDLFs treated with different concentrations IL-10 (0, 1, 10, 25, 50, 100 ng/mL) or 5.5, 20, 30, 40 mmol/L). Changes examined using the reverse-transcription polymerase chain reaction (RT-PCR) Western blot analysis, respectively. After treatment, levels...
Background Patients with acute ischemic stroke (AIS) and a large core may benefit from endovascular treatment (EVT) in the early time window. Purpose To examine prognostic factors for good outcomes patients (70–130 ml) after EVT. Materials methods We retrospectively reviewed 40 who met criteria October 2019 to April 2021. Based on modified Rankin Score (mRS) at 90 days, were divided into outcome group (mRS 0–2) poor 3–6). Baseline procedural characteristics collected unilateral multivariate...
The optimal treatment strategy for elderly patients with ruptured intracranial aneurysms (IAs) remains controversial. We evaluated a national, multihospital database to compare the outcomes of aggressive and medical management those patients.
Abstract Acute embolism of the superior cerebellar artery is rarely reported. The treatment mainly medication, decompressive craniectomy performed when necessary, and mechanical thrombus removal not recommended. This article describes admission a 69-year-old man with acute embolization. Compared imaging data patient 2 weeks before onset disease, cerebral angiography revealed that there was mural covering opening artery. it also bold attempt for this to undergo thrombectomy. finally recovered...
Abstract Patients with basilar artery occlusion (BAO) stroke tend to have poor prognoses. This study aimed explore the impact of BAO location on recanalization rate and clinical outcome after endovascular therapy (EVT). acute who underwent EVT between March 2014 October 2022 at four centers were included in this study. The sites classified as proximal, middle, distal according angiographic findings. favorable measures for successful recanalization, defined modified thrombolysis cerebral...
Objective To compare the diagnostic values of 3 - dimention computed tomography angiography (3D CTA ) and digital subtraction ( 3D DSA) in intracranial aneurysms.Methods Forty -six patients with spontaneous subarachnoid hemorrhage (sSAH) admitted from June 2009 to 2010 performed DSA examinations.The characteristics -CTA images were compared.Results Fifty two aneurysms found 43 patients.There was no significant difference accuracy between -DSA.Conclusions could be first choice for hemorrhage....