A5101831213- Immune Cell Function and Interaction
- Cancer Research and Treatments
- 3D Printing in Biomedical Research
- Immune cells in cancer
- Cancer Cells and Metastasis
- CAR-T cell therapy research
- Pluripotent Stem Cells Research
- interferon and immune responses
- Mechanisms of cancer metastasis
- Reproductive System and Pregnancy
- Hedgehog Signaling Pathway Studies
- T-cell and B-cell Immunology
- Kruppel-like factors research
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Metabolomics and Mass Spectrometry Studies
CHA Bundang Medical Center
2021-2025
CHA University
2021-2025
Patient-derived xenograft (PDX) models are powerful tools in cancer research, offering an accurate platform for evaluating treatment efficacy and predicting responsiveness. However, these necessitate surgical techniques tumor tissue transplantation face challenges with non-uniform growth among animals. To address issues, we attempted to develop a new PDX modeling method using high-grade serous ovarian (HGSC), fatal disease 5-year survival rate of 29%, which requires personalized research due...
A cancer-associated fibroblasts (CAFs) are the most important players that modulate tumor aggressiveness. In this study, we aimed to identify CAF-related genes in ovarian serous carcinomas (OSC) account for high incidence and mortality of cancers (OCs) develop therapeutic targets microenvironment modulation. Here, performed a microarray analysis CAFs isolated from three metastatic nonmetastatic OSC tissues compared their gene expression profiles. Among increased (mCAFs), GLIS1 (Glis Family...
Recurrent glioblastoma multiforme (GBM) is a highly aggressive primary malignant brain tumor that resistant to existing treatments. Recently, we reported activated autologous natural killer (NK) cell therapeutics induced marked increase in survival of some patients with recurrent GBM.To identify biomarkers predict responsiveness NK therapeutics, examined immune profiles tissues using NanoString nCounter analysis and compared the between 5 responders 7 non-responders. Through three-step data...
Abstract Background Recently, allogeneic natural killer (NK) cells have gained considerable attention as promising immunotherapeutic tools due to their unique biological functions and characteristics. Although many NK expansion strategies been reported previously, a deeper understanding of cryopreserved is needed for specific therapeutic approaches. Methods We isolated CD3 − CD56 + primary (pNK) from healthy donors expanded them ex vivo using GMP-compliant method without any feeder generate...
Allogeneic natural killer (NK) cell therapy has been effective in treating cancer. Many studies have tested NK using human pluripotent stem cells (hPSCs). However, the impacts of origin PSC-NK on competence are unclear. In this study, several types hPSCs, including human-induced PSCs (hiPSCs) generated from CD34+, CD3-CD56+, and CD56- umbilical cord blood (UCB), three lines embryonic (hESCs, ES-1. ES-2 ES-3) MHC I knockout (B2M-KO)-ESCs were used to differentiate into their capacities...
Patient-derived xenograft (PDX) models are powerful tool in cancer research, offering a more accurate platform for evaluating the treatment efficacy and predicting responsiveness. However, these necessitate surgical techniques tumor tissue transplantation face challenges with non-uniform growth among animals. To address issues, we attempted to develop new PDX modeling method using high-grade serous ovarian (HGSC), fatal disease 5-year survival rate of 29%, that requires personalized research...
Abstract Background Recurrent glioblastoma multiforme (GBM) is a highly aggressive primary malignant brain tumor that resistant to existing treatments. Recently, we reported activated autologous natural killer (NK) cell therapeutics induced marked increase in survival of some patients with recurrent GBM. Methods To identify biomarkers predict responsiveness NK therapeutics, examined immune profiles tissues using NanoString nCounter analysis and compared the between 5 responders 7...