A5061445481- Hemoglobinopathies and Related Disorders
- Chronic Myeloid Leukemia Treatments
- Iron Metabolism and Disorders
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Kruppel-like factors research
- 3D Printing in Biomedical Research
- Religion, Spirituality, and Psychology
- Cancer Cells and Metastasis
- Eosinophilic Disorders and Syndromes
- Cancer Research and Treatments
- COVID-19 and healthcare impacts
- CNS Lymphoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Drug Transport and Resistance Mechanisms
- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- Pregnancy and preeclampsia studies
- Acute Lymphoblastic Leukemia research
- Hemophilia Treatment and Research
- Folate and B Vitamins Research
- Acute Myeloid Leukemia Research
- Fungal Plant Pathogen Control
CHA Bundang Medical Center
2025
CHA University
2025
Hospital Pulau Pinang
2013-2024
Ministry of Health
2021-2022
Hospital Seberang Jaya
2021
RCSI & UCD Malaysia Campus
2021
Penang Adventist Hospital
2004-2018
Patient-derived xenograft (PDX) models are powerful tools in cancer research, offering an accurate platform for evaluating treatment efficacy and predicting responsiveness. However, these necessitate surgical techniques tumor tissue transplantation face challenges with non-uniform growth among animals. To address issues, we attempted to develop a new PDX modeling method using high-grade serous ovarian (HGSC), fatal disease 5-year survival rate of 29%, which requires personalized research due...
Summary Some patients with relapsed/refractory Hodgkin lymphoma ( HL ) are not considered suitable for stem cell transplant SCT and have a poor prognosis. This phase IV study (NCT01990534) evaluated brentuximab vedotin (1·8 mg/kg intravenously once every 3 weeks) in 60 (aged ≥18 years) CD30‐positive , history of ≥1 prior systemic chemotherapy regimen, who were unsuitable /multi‐agent chemotherapy. Primary endpoint was overall response rate ORR per independent review facility IRF ). Secondary...
The evolution of molecular studies in myeloproliferative neoplasms (MPN) has enlightened us the understanding this complex disease consisting polycythaemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). epidemiology is well described western world but not Asian countries like Malaysia.This retrospective national registry MPN was conducted from year 2009 to 2015 Malaysia.A total 1010 patients were registered over a period 5 years. mean age 54 years with male...
Improvement in medical management has enabled transfusion dependent thalassaemia (TDT) patients to survive beyond childhood, building families, and contributing the labour force society. Knowledge about their adult life would provide guidance on how support needs. This study aims explore general well-being of adults with TDT, employment status challenges.This recruited 450 people aged 18 above, both genders through all regional Thalassaemia societies Malaysia from two participating...
Background: Diffuse large B-cell lymphoma (DLBCL) with double expression of c-MYC and BCL2 protein is associated dismal outcome after treatment R-CHOP. Local data on disease burden survival in DLBCL limited. We investigated the prognostic values c-MYC/BCL2 co-expression cell origin subtypes using immunohistochemistry (IHC) to determine their associations multiethnic groups under resource limited setting. Methods: This was a retrospective study which recruited 104 patients between June 2012...
Abstract Haemoglobin (Hb) Adana (HBA2:c.179>A) interacts with deletional and nondeletional α-thalassaemia mutations to produce HbH disorders varying clinical manifestations from asymptomatic severe anaemia significant hepatosplenomegaly. Hb carriers are generally haemoglobin subtyping is unable detect this highly unstable α-haemoglobin variant. This study identified 13 patients compound heterozygosity for either the 3.7 kb gene deletion (-α ), Constant Spring (HbCS) (HBA2:c.427T>C) or...
Vitamin B12 deficiency and folate are common causes of macrocytic anaemia both important for many cellular processes. These deficiencies could be due to inadequate dietary intake, impaired absorption or drug ingestion. We present a case 47-year-old male with history diffuse large B-cell lymphoma (DLBCL) who was admitted fatigue, persistent frontal headache left upper-quadrant abdominal pain. Further investigation showed that he had pancytopenia microangiopathic haemolytic (MAHA) intracranial...
Patient-derived xenograft (PDX) models are powerful tool in cancer research, offering a more accurate platform for evaluating the treatment efficacy and predicting responsiveness. However, these necessitate surgical techniques tumor tissue transplantation face challenges with non-uniform growth among animals. To address issues, we attempted to develop new PDX modeling method using high-grade serous ovarian (HGSC), fatal disease 5-year survival rate of 29%, that requires personalized research...
A middle-aged gentleman who was diagnosed with high-risk chronic lymphocytic leukaemia (CLL), Rai stage IV, Binet C del(17p) and del(13q) underwent allogeneic haematopoeitic stem cell transplantation (allo-HSCT) from a human leukocyte antigen (HLA) identical sister. The patient developed extensive skin, oral, liver graft versus host disease (GVHD) required tacrolimus, mycophenolate mofetil (MMF), prednisolone. At seventh month after allo-HSCT, the presented systemic symptoms, right cervical...
Beta-thalassaemia is an autosomal recessive disorder and it a public health problem in the Malaysian Malays Chinese. This mainly results from point mutations, small insertion or deletions β-globin gene complex. major patients require life-long monthly blood transfusions iron-chelation therapies to sustain their lives. Mutation characterisation necessary for affected couples at risk of having β-thalassaemia child. 1. To develop TaqMan genotyping platform as time- cost-effective approach...
Abstract Background Improvement in medical management has enabled transfusion dependent thalassaemia (TDT) patients to survive beyond childhood, building families, and contributing the labour force society. Knowledge about their adult life would provide guidance on how support needs. This study aims explore general well-being of adults with TDT, employment status challenges. Methods We contacted all regional Thalassaemia societies Malaysia invite TDT members aged 18 or over participate....