A5078718757- Virus-based gene therapy research
- Inflammasome and immune disorders
- Drug Transport and Resistance Mechanisms
- Bone and Dental Protein Studies
- Eicosanoids and Hypertension Pharmacology
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects and Toxicity Studies
- Drug Solubulity and Delivery Systems
- Immunotherapy and Immune Responses
- Renin-Angiotensin System Studies
- Alkaline Phosphatase Research Studies
- Pharmacogenetics and Drug Metabolism
- Poisoning and overdose treatments
- Caveolin-1 and cellular processes
- Sphingolipid Metabolism and Signaling
- Acute Kidney Injury Research
- Liver physiology and pathology
- Animal Genetics and Reproduction
University of Cambridge
2023
Center for Drug Evaluation and Research
2007-2010
National Institutes of Health
1996-1999
National Cancer Institute
1996
Abstract Limitations of existing biomarkers to detect liver injury in experimental animals highlight the need for additional tools predict human toxicity. The utility cytochrome c (cyt c) as a biomarker serum and urine was evaluated two rodent models. Adult Sprague–Dawley rats treated with acetaminophen or d ‐galactosamine (GalN) showed dose‐ time‐dependent histomorphological changes TUNEL staining consistent hepatocellular necrosis, apoptosis inflammation up 72 h. Matching alanine...
Unabated activation of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome is linked with pathogenesis various inflammatory disorders. Polo-like kinase 1 (PLK1) has been widely studied for its role in mitosis. Here, using both pharmacological and genetic approaches, we demonstrate that PLK1 promoted NLRP3 at cell interphase. Using an unbiased proximity-dependent biotin identification (Bio-ID) screen interactome macrophages, show enhanced proximal association upon activation. We...
Hepatic silicosis, cirrhosis, liver cell adenoma, and carcinomas developed in nude mice (NCr-Nu) given quartz by the subcutaneous intraperitoneal routes. Syrian golden hamsters (15:16 EHS:cr) both routes extensive fibrosis cirrhosis had higher morbidity mortality rates after 3 months. Crystalline silica (quartz) induces fibrosis, adenomas, lungs of Fisher 344 rats, but certain strains are resistant to quartz-induced pulmonary carcinogenesis. Pulmonary however, is minimal absent who received...
Exposure of the vasculature to vasodilators, pharmaceuticals and industrial chemicals may lead injury blood vessel wall in animals. Vascular begin with changes permeability vascular endothelial cell vessels, resulting possible hemorrhage edema leading subsequently immune infiltration. The present study was undertaken determine if direct exposure Sprague Dawley rat mesenteric through perfusion aminophylline, fenoldopam, compound 48/80, histamine or serotonin has any such effects on two vital...
Clinical Pharmacology & Therapeutics (1999) 65, 199–199; doi: