A5001085098- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Cell Adhesion Molecules Research
- Spanish Linguistics and Language Studies
- Sphingolipid Metabolism and Signaling
- Immune Response and Inflammation
- Second Language Learning and Teaching
- Platelet Disorders and Treatments
- Micro and Nano Robotics
- Literacy and Educational Practices
- Phagocytosis and Immune Regulation
- Tissue Engineering and Regenerative Medicine
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Linguistic Education and Pedagogy
- Microtubule and mitosis dynamics
- Educational Technology in Learning
- Cellular Mechanics and Interactions
- Caveolin-1 and cellular processes
- Adipokines, Inflammation, and Metabolic Diseases
- Translation Studies and Practices
- IL-33, ST2, and ILC Pathways
- Cancer Immunotherapy and Biomarkers
- linguistics and terminology studies
Heidelberg University
2021-2023
University of Cambridge
2017-2023
Medigene (Germany)
2020
Ludwig-Maximilians-Universität München
2017-2018
Urologische Klinik München
2018
European Molecular Biology Laboratory
2017-2018
Abstract Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is involved in many chronic inflammatory diseases, including cardiovascular and Alzheimer’s disease. Here we show that microtubule-affinity regulating kinase 4 (MARK4) binds to NLRP3 drives it microtubule-organizing centre, enabling formation one large speck complex within a single cell. MARK4 knockdown or knockout, disruption MARK4-NLRP3 interaction, impairs spatial arrangement limits activation....
Surface contraction waves (SCWs) in oocytes and embryos lead to large-scale shape changes coupled cell cycle transitions are spatially coordinated with the axis. Here, we show that SCWs starfish oocyte generated by a traveling band of myosin II-driven cortical contractility. At front band, contractility is activated removal cdk1 inhibition RhoA/RhoA kinase/myosin II signaling module, while at rear, switched off negative feedback originating downstream RhoA kinase. The SCW's directionality...
MARK4 (microtubule affinity-regulating kinase 4) regulates NLRP3 (nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain containing 3) inflammasome activation. The aim of the study is to examine role in hematopoietic cells during atherosclerosis.We show increased expression human atherosclerotic lesions compared with adjacent areas. coexpressed NLRP3, they colocalize areas enriched CD68-positive but α-SMA (α-smooth muscle actin)-negative cells. Expression associated...
Unabated activation of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome is linked with pathogenesis various inflammatory disorders. Polo-like kinase 1 (PLK1) has been widely studied for its role in mitosis. Here, using both pharmacological and genetic approaches, we demonstrate that PLK1 promoted NLRP3 at cell interphase. Using an unbiased proximity-dependent biotin identification (Bio-ID) screen interactome macrophages, show enhanced proximal association upon activation. We...
la L2.Las estrategias empleadas en cada tipo de mediación ayudan a orientar práctica el aula fomentando un mayor uso lengua meta.
En la mediación textual propuesta por el Marco Común de Referencia Europeo (MCER), aprendiz debe transmitir contenido un texto original mediante estrategias como condensación, reformulación y traducción. A diferencia traducción profesional, prevé mayor grado flexibilidad en cuanto a forma expresión, pues principal cometido es adecuarse las exigencias situación comunicativa. Por este motivo, constituye una práctica pedagógica adecuada para formación traductores educación terciaria, que les...
El CLIL (Content Language Integrated Learning) es un enfoque en el que se emplea una L2 como lengua de instrucción para la transmisión contenidos. Tanto aprendizaje del contenido, adquisición extranjera, ha demostrado su eficacia frente a enfoques tradicionales. Numerosas investigaciones empíricas evidencian mejor desarrollo competencia comunicativa oral y escrita, además procesamiento semántico. Sin embargo, mediación apenas sido estudiada. La textual, según Marco Común Referencia Europeo...
Resumen El Aprendizaje Integrado de Lengua y Contenidos o CLIL (por sus siglas en inglés, Content Language Integrated Learning ) constituye un enfoque ecléctico el que la lengua meta se emplea como medio para enseñanza contenidos diferentes áreas. En este contexto, las actividades comunicativas mediación propuestas por Marco Común Europeo Referencia (MCER) cobran especial interés. Este estudio a pequeña escala compara, partir una actividad lingüística procesamiento textual, rendimiento dos...
Abstract Introduction: The use of cellular immunotherapies has led to impressive complete and durable clinical responses in patients with certain types hematological cancers. However, positive results solid tumor indications are still rare many urgent need alternative treatment options for several different indications. It become clear that expression inhibitory immune checkpoint molecules as well harsh metabolic conditions the microenvironment (TME) responsible lack activity T cell...