A5012052121- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital heart defects research
- Curcumin's Biomedical Applications
- Lung Cancer Research Studies
- Inflammasome and immune disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Sirtuins and Resveratrol in Medicine
- Aldose Reductase and Taurine
- Advanced biosensing and bioanalysis techniques
- Autism Spectrum Disorder Research
- Adenosine and Purinergic Signaling
- Heat shock proteins research
- COVID-19 and Mental Health
- Lung Cancer Treatments and Mutations
- Urinary Bladder and Prostate Research
Scripps Research Institute
2019-2024
University of Connecticut
2024
UConn Health
2018
Whittier College
2017
Significance Release of oligomeric/fibrillar α-synuclein (αSyn) from damaged neurons contributes to neuronal cell death in Parkinson’s disease and other neurodegenerative disorders part via microglial activation. Here, we show that αSyn activates the NLRP3 inflammasome human induced pluripotent stem (hiPSC)-derived microglia (hiMG) dual stimulation involving TLR2 engagement mitochondrial damage. Oligomerized amyloid-β peptide (Aβ), as found Alzheimer’s brains, exacerbates this...
Lung cancer is the second most common worldwide and leading cause of cancer-related death. While survival rates have improved with advancements in therapeutics, additional health challenges surfaced. Cardiovascular disease (CVD) a morbidity mortality patients lung cancer. CVD share many risk factors, such as smoking, hypertension, diabetes, advanced age, obesity. Optimal management this patient population requires full understanding potential cardiovascular (CV) complications treatment. This...
The Hyperpolarization activated, cyclic nucleotide gated (HCN) channel is a candidate mediator of neuroendocrine influence over detrusor tonus during filling. In other tissues, HCN loss with aging linked to declines in rhythmicity and function. We hypothesized that has an age-sensitive expression profile functional role adrenergic bladder relaxation. was examined bladders from young (2-6 months) old (18-24 C57BL/6 female mice, using qRT-PCR, RNAScope, Western blots. Isometric tension studies...
Abstract Resveratrol and curcumin are natural compounds consumed for both nutritional medicinal reasons. (and corresponding analog compounds) possess potent anti-inflammatory anti-oxidative properties. In addition, also have anti-proliferative effects against a number of cancer cell lines, including lymphomas. Cisplatin is chemotherapy medication used to treat cancers However, cisplatin, unlike resveratrol curcumin, harmful side such as neurotoxicity, nephrotoxicity, nausea vomiting that can...
Abstract MEF2C has been shown to be a critical transcription factor for neurodevelopment, whose loss-of-function mutation in humans results haploinsufficiency syndrome (MHS), severe form of autism spectrum disorder (ASD)/intellectual disability (ID). Here, we use patient hiPSC-derived cerebrocortical neurons and cerebral organoids characterize MHS deficits. Unexpectedly, found an aberrant micro-RNA-mediated gliogenesis pathway that contributes decreased neurogenesis. We also demonstrate...