Organic fluorescent nanoparticles, excitation-dependent photoluminescence, hydrogen-bonded clusters and lysobisphosphatidic acid are four interesting individual topics in materials biological sciences. They have attracted much attention not only because of their unique properties important applications, but also the nature intriguing phenomena remained unclear. Here we report a new type organic nanoparticles with intense blue visible fluorescence range 410–620 nm. The composed ten...

Iron oxide nanoparticles modified with oleate have been employed for the extraction of peptides and proteins from aqueous solution before matrix-assisted laser desorption/ionization (MALDI) mass spectrometric (MS) analysis. Adsorption onto were mainly through electrostatic attraction hydrophobic interaction. The analyte-adsorbed iron could be efficiently collected using a magnet. No elution step was needed. With this preconcentration strategy, lowest detectable concentration angiotensin I,...

A novel method for the determination of aminoglycosides by surface-assisted laser desorption/ionization mass spectrometry (SALDI MS) with aid silver-coated gold nanoparticles (Au@AgNPs) has been developed. The Au@AgNPs surface capped anionic citrate were used as concentrating probes well matrices in SALDI MS. Adsorption onto was mainly through electrostatic attraction. aminoglycoside-adsorbed directly characterized MS after a simple washing. Using to preconcentrate from 500 µL buffer...

A rapid, simple and sensitive method for the detection of piperazinyl phenothiazine drugs using dispersive liquid-liquid microextraction (DLLME) combined with field-amplified sample stacking (FASS) in CE was developed. Sensitivity parameters that affect extraction FASS efficiency, such as type volume disperser solvent, time, addition salt, efficiency FASS, were investigated optimized. Note conductivity ratio between BGE zone measured to be 2300. Under optimal conditions, calibration curve,...

A novel method for the determination of macrolide antibiotics using dispersive liquid-liquid microextraction coupled to surface-assisted laser desorption/ionization mass spectrometric detection was developed. Acetone and dichloromethane were used as disperser solvent extraction solvent, respectively. mixture rapidly injected into a 1.0 mL aqueous sample form cloudy solution. After extraction, detected spectrometry (SALDI/MS) with colloidal silver matrix. Under optimum conditions, limits...

A sensitive method for the determination of mexiletine and lidocaine using surfactant-assisted dispersive liquid-liquid microextraction coupled with capillary electrophoresis was developed. Triton X-100 dichloromethane were used as agent extraction solvent, respectively. After extraction, analyzed ultraviolet detection. The detection sensitivity further enhanced through use field-amplified sample stacking. Under optimal stacking conditions, calibration curves linear over a concentration...

Abstract A new version of dispersive liquid–liquid microextraction, namely, cyclodextrin‐assisted with subsequent sweeping micellar electrokinetic chromatography has been developed for the preconcentration and sensitive detection carbamazepine clobazam. α‐Cyclodextrin chloroform were used as agent extraction solvent, respectively. After extraction, clobazam analyzed using ultraviolet detection. The sensitivity was further enhanced technique. Under optimal stacking conditions, calibration...

An enantioselective method for baclofen (4-amino-3-p-chlorophenylbutyric acid) based on capillary electrophoresis (CE) separation and laser-induced fluorescence (LIF) detection has been developed. Naphthalene-2,3-dicarboxaldehyde (NDA) was used precolumn derivatization of the nonfluorescent drug. α-Cyclodextrin (α-CD) included in buffer as a chiral selector NDA-labeled S-(+)- R-(—)-baclofen. Optimal resolution were obtained with an electrophoretic 50mM sodium borate (pH9.5) containing 7mM...

Glucose-sensitive neurons in the lateral hypothalamic area produce orexin-A (OxA) as well orexin-B (OxB) and send their axons to spinal dorsal horn, which predominantly expresses orexin receptor-1 (OX-1), showing a higher sensitivity OxA. The purpose of present study was assess effects OxA on induction novel form activity-dependent reflex potentiation, potentiation (SRP), pelvic-urethral activity. External urethra sphincter electromyogram response pelvic afferent nerve test stimulation (TS;...

Mass spectrometry (MS) is usually coupled on-line with capillary electrophoresis (CE) to analyze biomolecules by using electrospray ionization or continuous-flow fast-atom bombardment. We present a new design for laser vaporization/ionization time-of-flight mass spectrometry. CE, its low flow rate (<1 μL/min), highly compatible MS, even if the total column effluent introduced directly. A UV used vaporize and ionize solution eluting from column. There no need have makeup solvent. Using this...

Capillary electrophoresis (CE) with indirect fluorescence detection was used to analyze selenium (selenite, selenate, selenomethionine, and selenocystine) antimony (antimonite antimonate) compounds. The separation achieved by CE in 6 min a 1.2 mM fluorescein solution at pH 9.5. Fluorescein also functioned as background fluorophore for the of these nonfluorescent species. Linearity more than two orders magnitude generally obtained. Precision migration times peak areas less 1.0% 7.2%,...

Rationale Rivaroxaban is a new anticoagulant drug that has recently been introduced for clinical applications. To ensure optimum efficacy while minimizing the risk of toxicity and other adverse effects, simple sensitive analytical procedure monitoring concentration rivaroxaban in biological fluids required. Methods was extracted from aqueous solutions by dispersive liquid‐liquid microextraction (DLLME). Detection achieved through surface‐assisted laser desorption/ionization mass spectrometry...

A capillary electrophoresis (CE) with UV absorption detection method is described for the simultaneous determination of glufosinate, glyphosate, and aminomethylphosphoric acid. The 9-fluorenylmethyl chloroformate (FMOC-Cl) was used precolumn derivatization non-absorbing herbicides. three analytes were separated by CE in 9 min 25 mM borate buffer at pH 9, followed a detector 260 nm. We demonstrate how limit can be enhanced using acetonitrile-salt mixtures. With mixtures, (LOD) 10−7 M range....

A simple, rapid, and sensitive method for the detection of posaconazole using dispersive liquid-liquid microextraction (DLLME) coupled to surface-assisted laser desorption/ionization mass spectrometric (SALDI/MS) was developed. After DLLME, detected SALDI/MS with colloidal gold α-cyano-4-hydroxycinnamic acid (CHCA) as co-matrix. Under optimal extraction conditions, calibration curve, which ranged from 1.0 100.0 nM posaconazole, observed be linear. The limit (LOD) at a signal-to-noise ratio 3...

Abstract Silica nanoparticles (SiNPs) have been used as concentrating probes to extract paraquat and diquat from aqueous solution before capillary electrophoretic analysis. Adsorption of onto SiNPs is mainly through electrostatic interaction. After extraction centrifugation, the analytes were eluted surface SINPs by rinsing with acetic acid solution. The was directly analyzed electrophoresis UV absorption detection. Using concentrate 10 mL solution, enrichment factors for 75 192,...