A5001962218- Skin Protection and Aging
- Vitamin D Research Studies
- Vitamin C and Antioxidants Research
- Psoriasis: Treatment and Pathogenesis
- Retinoids in leukemia and cellular processes
- melanin and skin pigmentation
- Photodynamic Therapy Research Studies
- Ethics in medical practice
- Genomics, phytochemicals, and oxidative stress
- Antioxidant Activity and Oxidative Stress
- Pharmacological Effects and Assays
- Veterinary Pharmacology and Anesthesia
- Healthcare Decision-Making and Restraints
- Cancer Immunotherapy and Biomarkers
- Ethics and Legal Issues in Pediatric Healthcare
- PI3K/AKT/mTOR signaling in cancer
- Melanoma and MAPK Pathways
- Climate Change and Health Impacts
- Wound Healing and Treatments
- Acne and Rosacea Treatments and Effects
- bioluminescence and chemiluminescence research
- Thermoregulation and physiological responses
- Estrogen and related hormone effects
- Organ Donation and Transplantation
- Art History and Market Analysis
The University of Sydney
2012-2024
Robert Bosch (Australia)
2006-2021
University of North Carolina at Chapel Hill
2020
Robert Bosch (India)
2013
University of California, Riverside
2011
Bowling Green State University
1994-1999
Melanoma, originating through malignant transformation of melanin-producing melanocytes, is a formidable malignancy, characterized by local invasiveness, recurrence, early metastasis, resistance to therapy, and high mortality rate. This review discusses etiologic risk factors for melanoma, diagnostic prognostic tools, including recent advances in molecular biology, omics, bioinformatics, provides an overview its therapy. Since the incidence melanoma rising remains unacceptably high, we...
Abstract The immunomodulatory effects of vitamin D have been described following chronic oral administration to mice or supplementation cell cultures with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active form D. In this study, topically applied 1,25(OH)2D3, enhanced suppressive capacity CD4+CD25+ cells from draining lymph nodes. topical 1,25(OH)2D3 were compared those UVB irradiation, which is environmental factor required for production in skin. CD4+ skin-draining nodes (SDLN) either...
Exposure to ultraviolet radiation (UVR) can lead a range of deleterious responses in the skin. An important form damage is DNA photolesion cyclobutane pyrimidine dimer (CPD). CPDs be highly mutagenic if not repaired prior cell division and UV-induced immunosuppression, making them potentially carcinogenic. UVR exposure also produces vitamin D, prehormone. Different shapes steroid hormone 1α,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] produce biological through binding either its cognate nuclear...
Calcitriol, the biologically active form of vitamin D, has been reported to cause both suppressive and protective immune effects in mice. Its vivo humans are unclear. We investigated topical calcitriol on minimal erythema dose skin responses healthy volunteers. found that did not protect from ultraviolet (UV)-induced (sunburn) when applied either 24 h before or immediately after irradiation, although it decreased density sunburn cells thymine dimers seen biopsy again irradiation. Using...
Children continue to experience harm when undergoing clinical procedures despite increased evidence of the need improve provision child-centred care. The international ISupport collaboration aimed develop standards outline and explain good procedural practice rights children within context a procedure. rights-based for tests, treatments, investigations, examinations interventions were developed using an iterative, multi-phased, multi-method multi-stakeholder consensus building approach. This...
The vitamin D hormone, 1,25dihydroxyvitamin D3 (1,25(OH)2D3), and related compounds derived from or lumisterol as a result of metabolism via the enzyme CYP11A1, have been shown, when applied 24 hours before immediately after UV irradiation, to protect human skin cells DNA damage due exposure, by reducing both cyclobutane pyrimidine dimers (CPD) oxidative in form 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OHdG). We now report that knockdown either receptor endoplasmic reticulum protein ERp57...
The hormonal form of vitamin D3, 1,25(OH)2D3, reduces UV-induced DNA damage. UV exposure initiates pre-vitamin D3 production in the skin, and continued photoisomerizes to produce "over-irradiation products" such as lumisterol3 (L3). Cytochrome P450 side-chain cleavage enzyme (CYP11A1) skin catalyzes conversion L3 three main derivatives: 24-hydroxy-L3 [24(OH)L3], 22-hydroxy-L3 [22(OH)L3], 20,22-dihydroxy-L3 [20,22(OH)L3]. current study investigated photoprotective properties major...
PTEN is a well-known tumour suppressor protein that frequently found to be mutated, inactivated or deleted in wide range of different cancers. Its suppressive properties result predominantly from its inhibitory effects on the PI3K-AKT signalling pathway. In melanoma, numerous mutations have been identified both melanoma cell lines and tissue. A number molecules can act either promote suppression while other may antagonise inhibit mechanism action against melanoma. This review will discuss...
Abstract Common therapeutics in relation to melanoma and non-melanoma cancers include the use of kinase inhibitors. The long-term benefits kinases, however, are limited by development drug resistance. An alternative approach for treatment would be focus on transcription factors. Cyclic AMP-regulatory element-binding protein (CREB) is a factor that commonly overactivated or overexpressed many different including skin cancer. Ultraviolet radiation (UVR), one main causes cancer, can activate...