A5082772158- Skin Protection and Aging
- Vitamin D Research Studies
- melanin and skin pigmentation
- Psoriasis: Treatment and Pathogenesis
- Acne and Rosacea Treatments and Effects
- Vitamin C and Antioxidants Research
- Sentiment Analysis and Opinion Mining
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Text and Document Classification Technologies
- Stress Responses and Cortisol
- Biochemical Analysis and Sensing Techniques
- Neural dynamics and brain function
- Coronary Interventions and Diagnostics
- Sustainability and Ecological Systems Analysis
- Topic Modeling
- stochastic dynamics and bifurcation
- PARP inhibition in cancer therapy
- Photoreceptor and optogenetics research
- Aortic aneurysm repair treatments
- Photodynamic Therapy Research Studies
- Aortic Disease and Treatment Approaches
- Gene Regulatory Network Analysis
- Retinoids in leukemia and cellular processes
- Olfactory and Sensory Function Studies
The University of Sydney
2010-2024
Robert Bosch (Australia)
2021
Kunming University of Science and Technology
2021
University of California, Los Angeles
2020
Transition of electric activity neuron can be induced by autapse, and its action potential is much sensitive to the stimuli from autapse. Generally, effect autapse on membrane often described using time-delayed feedback in closed loop. Based Pspice software, a class circuit designed with being taken into consideration, used detect adjusting potential. Results are found as follows: (1) The neuronal produce quiescent state, spiking, bursting state under an external force besides circuit. (2)...
The vitamin D hormone, 1,25dihydroxyvitamin D3 (1,25(OH)2D3), and related compounds derived from or lumisterol as a result of metabolism via the enzyme CYP11A1, have been shown, when applied 24 hours before immediately after UV irradiation, to protect human skin cells DNA damage due exposure, by reducing both cyclobutane pyrimidine dimers (CPD) oxidative in form 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OHdG). We now report that knockdown either receptor endoplasmic reticulum protein ERp57...
The hormonal form of vitamin D3, 1,25(OH)2D3, reduces UV-induced DNA damage. UV exposure initiates pre-vitamin D3 production in the skin, and continued photoisomerizes to produce "over-irradiation products" such as lumisterol3 (L3). Cytochrome P450 side-chain cleavage enzyme (CYP11A1) skin catalyzes conversion L3 three main derivatives: 24-hydroxy-L3 [24(OH)L3], 22-hydroxy-L3 [22(OH)L3], 20,22-dihydroxy-L3 [20,22(OH)L3]. current study investigated photoprotective properties major...
Susceptibility to photoimmune suppression and photocarcinogenesis is greater in male than female humans mice exacerbated estrogen receptor-beta knockout (ER-β-/-) mice. We previously reported that the active vitamin D hormone, 1,25-dihydroxyvitamin D3 (1,25(OH)2D), applied topically protects against ultraviolet radiation (UV) induction of cutaneous cyclobutane pyrimidine dimers (CPDs) contact hypersensitivity (CHS) Here, we compare these responses versus Skh:hr1 mice, ER-β-/-/-- wild-type...
ABSTRACT The epidermis maintains a cellular calcium gradient that supports keratinocyte differentiation from its basal layers (low) to outer (high) leading the development of stratum corneum, which resists penetration UV radiation. calcium‐sensing receptor (CaSR) expressed in keratinocytes responds with signals promote differentiation. In this study, we investigated whether CaSR is involved more directly protection damage studies human primary culture and mouse skin studied vivo ....
Gene transcription regulation is a noisy process that can lead to regime shifts and these are difficult predict. In this letter, we consider spatiotemporal fluctuations in gene regulation, employ spatially extended system by using theoretical analysis numerical simulation. We find the produces shift from low (high) high (low) protein concentration state (i.e., transform of switch regulation), apply spatial early warning signals (e.g., rising variance, skewness, kurtosis, lag-1...
In online video platforms, reading or writing comments on interesting videos has become an essential part of the watching experience. However, existing recommender systems mainly model users' interaction behaviors with videos, lacking consideration in user behavior modeling. this paper, we propose a novel recommendation approach called LSVCR by leveraging histories both and comments, so as to jointly conduct personalized comment recommendation. Specifically, our consists two key components,...
Photoprotective properties of 1,25-dihydroxyvitamin D
The calcium-sensing receptor (CaSR) is an important regulator of epidermal function. We previously reported that knockdown the CaSR or treatment with its negative allosteric modulator, NPS-2143, significantly reduced UV-induced DNA damage, a key factor in skin cancer development. subsequently wanted to test whether topical NPS-2143 could also reduce UV-DNA immune suppression, tumour development mice. In this study, application (228 2280 pmol/cm2) Skh:hr1 female mice cyclobutane pyrimidine...
Susceptibility to photoimmune suppression and photocarcinogenesis is greater in male than female humans mice exacerbated estrogen receptor-beta knockout (ER-β-/-) mice. We previously reported that the active vitamin D hormone, 1,25-dihydroxyvitamin D3 (1,25(OH)2D) applied topically protects against ultraviolet radiation (UV)-induction of cutaneous cyclobutane pyrimidine dimers (CPDs) contact hypersensitivity (CHS) Here we compare these responses versus Skh:hr1 mice, ER-β-/-...