A5041376512- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- Allergic Rhinitis and Sensitization
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- HIV Research and Treatment
- Glycosylation and Glycoproteins Research
- Hepatitis C virus research
- Pneumonia and Respiratory Infections
- Malaria Research and Control
- T-cell and B-cell Immunology
- Viral gastroenteritis research and epidemiology
- Genomics and Phylogenetic Studies
- Asthma and respiratory diseases
- Transgenic Plants and Applications
- Animal Virus Infections Studies
- Antimicrobial Peptides and Activities
- Animal testing and alternatives
- Invertebrate Immune Response Mechanisms
- Neonatal Respiratory Health Research
Stennis Space Center
2023
La Jolla Institute for Immunology
2009-2019
James Cook University
2018
Mackay Base Hospital
2018
National Academies of Sciences, Engineering, and Medicine
2007
University of California, Davis
2004
A major concern about the ongoing swine-origin H1N1 influenza virus (S-OIV) outbreak is that may be so different from seasonal little immune protection exists in human population. In this study, we examined molecular basis for pre-existing immunity against S-OIV, namely recognition of viral epitopes by T cells or B cells/antibodies have been previously primed circulating strains. Using data Immune Epitope Database, found only 31% (8/26) B-cell present recently strains are conserved with 17%...
Mass spectrometry (MS)-based immunopeptidomics investigates the repertoire of peptides presented at cell surface by major histocompatibility complex (MHC) molecules. The broad clinical relevance MHC-associated peptides, e.g. in precision medicine, provides a strong rationale for large-scale generation immunopeptidomic datasets and recent developments MS-based peptide analysis technologies now support required data. Importantly, availability diverse has resulted an increasing need to...
ABSTRACT Epitopes that arise from a somatic mutation, also called neoepitopes, are now known to play key role in cancer immunology and immunotherapy. Recent advances high-throughput sequencing have made it possible identify all mutations thereby potential neoepitope candidates an individual cancer. However, most of these not recognized by T cells patients when tested vivo or vitro, meaning they immunogenic. Especially with high mutational load, usually hundreds neoepitopes detected,...
Introduction The current outbreak of Zika virus has resulted in a massive effort to accelerate the development ZIKV-specific diagnostics and vaccines. These efforts would benefit greatly from definition specific epitope targets immune responses ZIKV, but given relatively recent emergence ZIKV as pandemic threat, few such data are available. Methods We used large body for other Flaviviruses that was available IEDB comparative analysis against proteome order project ZIKV. Results found...
Summary Epitopes identified in large‐scale screens of overlapping peptides often share significant levels sequence identity, complicating the analysis epitope‐related data. Clustering algorithms are used to facilitate these analyses, but available methods generally insufficient their capacity define biologically meaningful epitope clusters context immune response. To fulfil this need we developed an algorithm that generates based on representative or consensus sequences. This tool allows...
Easy access to a vast collection of experimental data on immune epitopes can greatly facilitate the development therapeutics and vaccines. The Immune Epitope Database Analysis Resource (IEDB) was developed provide such resource as free service biomedical research community. IEDB contains epitope assay information related infectious diseases, autoimmune allergic transplant/alloantigens for humans, nonhuman primates, mice, any other species studied. It T cell, B MHC binding, ligand elution...
Background Tuberculosis, caused by the bacterium Mycobacterium tuberculosis, remains a leading cause of infectious disease morbidity and mortality, is responsible for more than 2 million deaths year. Reports about extremely drug resistant (XDR) strains have further heightened sense urgency development novel strategies to prevent treat TB. Detailed knowledge epitopes recognized immune responses can aid in vaccine diagnostics development, provides important tools basic research. The analysis...
Introduction: The Queensland Remote Chemotherapy Supervision (QReCS) model enables rural nurses to administer chemotherapy in smaller towns under supervision by health professionals from larger centers using telehealth. Its implementation began North Queensland, Australia (population, 650,000), 2014 between two regional cancer (Townsville and Cairns as primary sites) six sites (125 1,000 kilometers sites). Our study examined the processes, feasibility, safety of this model. Methods: Details...
The Immune Epitope Database and Analysis Resource (IEDB) is dedicated to capturing, housing analyzing complex immune epitope related data http://www.immuneepitope.org.To identify extract relevant from the scientific literature in an efficient accurate manner, novel processes were developed for manual semi-automated annotation.Formalized curation strategies enable processing of a large volume context-dependent data, which are now available community accessible transparent format. experiences...
BACKGROUND Several monoclonal antibodies (mAb) are being evaluated as treatment options for the current 2014 Ebola outbreak. But they were derived from and tested protection against older 1976 Mayinga or 1995 Kikwit Zaire Ebolaviruses (EBOV). The EBOV sequences reported outbreak contain several mutations whose significance remained to be established. METHODS We analyzed sequence structural conservation of Ebolavirus glycoprotein (GP) epitopes all experimentally identified protective mAbs...
A significant fraction of the more than 18 million scientific articles currently indexed in PubMed database are related to immune responses various agents, including infectious microbes, autoantigens, allergens, transplants, cancer antigens and others. The Immune Epitope Database (IEDB) is an online repository that catalogs epitope reactivity data derived from listed National Library Medicine database. IEDB maintained continually updated by monitoring for new, potentially relevant references.
Summary Unwanted immune responses against protein therapeutics can reduce efficacy or lead to adverse reactions. T‐cell are key in the development of such responses, and directed immunodominant regions within sequence, often associated with binding several allelic variants HLA class II molecules (promiscuous binders). Herein, we report a novel computational strategy predict ‘de‐immunized’ peptides, based on previous studies erythropoietin immunogenicity. This algorithm (or method) first...
Adaptive immune responses associated with allergic reactions recognize antigens from a broad spectrum of plants and animals. Herein meta-analysis was performed on allergy-related data the epitope database (IEDB) to provide current inventory highlight knowledge gaps areas for future work. The analysis identified over 4,500 epitopes derived 270 different allergens. Overall, distribution followed expectations based nature responses. Namely, majority were defined B cells/antibodies IgE-mediated...