The objectives of this study were to investigate the use non-invasive biochemical markers evaluate severity liver fibrosis in patients with non-alcoholic steatohepatitis (NASH).This was a cross-sectional histopathologically confirmed NASH between January 2005 and December 2006. patients' characteristics recorded body mass index calculated for each patient. All underwent ultrasound-guided biopsy assessment performed using Brunt criteria. laboratory measured insulin resistance, tumor necrosis...

Background A non-invasive method to assess liver fibrosis by measuring stiffness with transient elastography (TE) has been recently introduced. The role of TE among chronic hepatitis B (CHB) patients in starting antiviral therapy the primary care setting is still controversial because its high cost. AST platelet ratio index (APRI) could be a much cheaper alternative. Objectives This study compares diagnostic accuracy and APRI assessing CHB patients. Patients Methods cross-sectional intending...

To obtain annual incidence trends, understand clinicopathological characteristics, and forecast the future burden of colorectal cancer (CRC) in Indonesia.

Aim: To obtain clinicopathological characteristics of colorectal cancer among young native Indonesians and to assess MLH1, MSH2, SMAD4 protein expressions, comparing them with a matched population patients aged 60 years old older.Methods: Medical records 40 or younger older from several hospitals in three Indonesian cities – Jakarta, Makassar, Bandung - were reviewed. The "native" ethnic groups selected those originating Java, Makassar (South Celebes), Minangkabau (West Sumatra). Ethnicity...

To study the prevalence of significant hepatic histopathology in chronic hepatitis B (CHB) patients with alanine aminotransferase (ALT) ≤ twice upper limit normal (ULN) and its association age, HBeAg status, virus (HBV)-DNA level viral genotype.A prospective was conducted over a 3-year period treatment-naive CHB ALT ULN. Patients history acute flare hepatitis, use alcohol hepatotoxic drugs, C, D human immunodeficiency (HIV) co-infection were excluded from study. Hepatic assessed according to...

The incidence of oral squamous cell carcinoma (OSCC) has not been well documented in Indonesia. Thus, we aimed to analyze trends and clinicopathological profiles OSCC cases Indonesia, focusing on differences between age sex groups.A cross-sectional study was conducted Indonesia's main referral hospital, analyzing 1,093 registered from 2001 2020. Trend analysis performed using Joinpoint regression determine the annual percentage change (APC) for overall each case group based age, sex,...

Aim. Nonalcoholic fatty liver disease (NAFLD) has been known as a risk for the presence of colon polyp and CRC development. This study was aimed to find out clinical significance polyps’ pathology among NAFLD patients. Method. A retrospective database done in patients who underwent elective colonoscopy within one-year period referral private hospital, Jakarta. Subjects were adult also had documented abdominal ultrasound (US). The association between colonic analyzed using Chi-square test...

The incidence profile of oral squamous cell carcinoma (OSCC) has not previously been comprehensively reported in Indonesia. present study aimed to identify clinicopathological characteristics patients with OSCC according sex and age, analyze histological differentiation patterns specific tumor subsites, highlight the role lymphovascular invasion (LVI) metastasis, develop a model predict advanced stage margin invasion. A retrospective cross-sectional was performed using 581 medical records...

Aims: To identify changing trends in gastrointestinal cancer incidence Indonesia according to age, gender, histopathology, and location.Methods: We examined retrospectively the demography, location, pathological characteristics of 295 consecutive patients admitted Cipto Mangunkusumo National General Hospital 2002-2006.We compared these data with from 343 2007-2011.The were analyzed by chi-square, analysis variance, Kolmogorov-Smirnov, Mann-Whitney U tests using SPSS 21.0.Results: The most...

Coinfection with human immunodeficiency virus (HIV) and hepatitis C (HCV) is common in Asia, but the effects of antiretroviral therapy (ART) are unclear. Histopathological changes liver described a prospective study HCV-seropositive HIV-infected patients at Cipto Mangunkusomo Hospital (Jakarta, Indonesia). Liver biopsy specimens were collected baseline (n = 48) 48 weeks 34). Ishak scores showed mild detectable inflammation and/or fibrosis. Levels portal declined during ART (P .03), whereas...

Colorectal cancer is currently the third most common in Indonesia, yet colonoscopy--the accepted mode of screening to date--is not done routinely and national data are still lacking.To determine detection rate colorectal cancers adenomas unselected patients undergoing colonoscopy for various large bowel symptoms at Digestive Disease GI Oncology Centre, Medistra Hospital Jakarta, Indonesia.Colonoscopy from January 2009 December 2012 were reviewed. New referred included. Data collected patient...

Background: Gastritis is an inflammation of the gastric mucosa as a response to infection or irritation gaster. The most common aetiology chronic gastritis Helicobacter pylori (H. pylori) infection. Presence H. associated with occurrence inflammation, atrophy, and intestinal metaplasia. In terms morphology, known in 2 forms, which are rod-shaped coccoid-shaped. Coccoid-shaped bacteria difficult detect using Giemsa staining. Therefore, immunohistochemistry staining evaluation sensitivity...

The present study aimed to determine the expression levels of p53 in patients with hepatocellular carcinoma (HCC) and evaluate its association several HCC-related prognostic factors particular, tumor stage, grade subtype. Therefore, a cross-sectional study, involving 41 HCC, who underwent surgical resection between January, 2013 December, 2020 was conducted. To assess all immunohistochemical staining performed. In addition, clinicopathological characteristics including factors, evaluated by...

Pancreatic gastrointestinal stromal tumors (PGISTs) are exceptionally rare, accounting for <5% of extra-gastrointestinal (EGISTs) and <1% malignant pancreatic neoplasms. We present a unique case concurrent double primary malignancies in 46-year-old female with history recurrent myoepithelial carcinoma the parotid gland, managed through surgical resection adjuvant therapy. She presented an enlarging abdominal mass, initially suggestive metastasis. Immunohistochemical analysis revealed...

Background: Non-alcoholic steatohepatitis (NASH) is an expanding cause of chronic liver disease worldwide, including Indonesia, with higher risk progression to cirrhosis and hepatocellular carcinoma. Preclinical experiments using several mice models have been conducted clarify its complex pathogenesis. This study was designed investigate whether BALB/c on a choline-deficient high-fat diet can be used as model for NASH. Materials Methods: male were fed L-amino acid-defined (CDAHFD) or...

Background: Chronic gastritis is commonly found with complains of dyspepsia, which may decrease work productivity. Imbalance between agressive and defensive factors the cause chronic gastritis. Therapy mostly directed to factors, particularly gastric acid very few studies are on factors. Mucus first defense mechanism mucosa. Fucoidan a phytopharmaca, thought increase thickness The objective this study was know mucosa in patients evaluate effect fucoidan Method: In double-blinded randomized...

Background Untreated gastroesophageal reflux can cause esophagitis, a condition characterized by damage to the esophageal mucous layer due exposure caustic gastric contents. Manifestation of esophagitis in young children include feedingproblems, irritability, and back􀀳arching. Persistent may growth failure, bleeding, anemia. Reflux should be considered an etiology feeding problems, especially with history during infancy.Objective The purpose this study is detennine prevalence...

Insulinoma is a rare endocrine tumor that causes hypoglycemia, with incidence of only 1–4 cases per 1 million population. Various clinical manifestations hypoglycemia may resemble neurological, psychiatric and cardiac problems, which result in diagnosis delay. In this case, we reported 30-year-old woman experiencing deterioration consciousness history repeated seizures, despite normal EEG, brain CT MRI. Multiphase contrast-enhanced abdominal showed hypovascular nodule, not typical for...

Meckel's diverticulum is the most prevalent congenital anomaly of gastrointestinal tract, identified in 2% population according to autopsy studies. Most patients remain asymptomatic throughout their lives and are typically diagnosed when complications arise. The diagnosis can be challenging, but imaging crucial for promptly identifying distinguishing it from other conditions that have similar clinical manifestations. A 13-year-old male was admitted with a 5-day history rectal bleeding....

Two Novel Amino Acid Insertions in the Helicobacter pylori rdxA Gene Detected Gastric Paraffin Biopsies