A5101710774- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Pluripotent Stem Cells Research
- Amyotrophic Lateral Sclerosis Research
- Sarcoidosis and Beryllium Toxicity Research
- Vasculitis and related conditions
- Intracranial Aneurysms: Treatment and Complications
- Pediatric Hepatobiliary Diseases and Treatments
- Neurogenetic and Muscular Disorders Research
- Sphingolipid Metabolism and Signaling
- Epigenetics and DNA Methylation
Japanese Red Cross Nagoya Daini Hospital
2025
Aichi Medical University
2024
Nagoya City University
2020-2022
Mizuho (Japan)
2021-2022
Although endoscopic transpapillary gallbladder drainage (ETGBD) has been reported as an alternative procedure for acute cholecystitis, it requires advanced techniques. In terms of the certainty achieving drainage, remains a challenging procedure. The aim current study was to elucidate practical efficacy cholangioscopic assistance and develop new classification that could be used evaluate technical difficulty ETGBD provide theoretical strategy apply cholangioscopy appropriately difficult...
Bile duct cannulation via balloon endoscopy-assisted endoscopic retrograde cholangiopancreatography (ERCP) can be challenging, particularly in complex anatomical scenarios [1] [2]. This case report emphasizes the clinical application of a novel rotatable sphincterotome 75-year-old man who presented to local clinic with 1-week history bilirubinuria. The patient had gastric cancer and undergone distal gastrectomy Roux-en-Y reconstruction 6 years previously. Laboratory tests revealed elevated...
Peritoneal dissemination and malignant ascites in pancreatic ductal adenocarcinoma (PDAC) patients represent a major clinical issue. Lysophosphatidic acid (LPA) is lipid mediator that modulates the progression of various cancers. Based on increasing evidence showing LPA abundant ascites, we focused autotaxin (ATX), which secreted enzyme important for production LPA. This study aimed to elucidate importance ATX-LPA axis PDAC determine whether ATX works as molecular target treating peritoneal...
Abstract We aimed to assess some of the potential genetic pathways for cancer development from non-malignant intraductal papillary mucinous neoplasm (IPMN) by evaluating mutations and methylation. In total, 46 dissected regions in 33 IPMN cases were analyzed compared between malignant-potential benign cases, or tissue including low-grade accompanied regions. Several gene mutations, methylations, proteins assessed pyrosequencing immunohistochemical analysis. RASSF1A methylation was more...
Amyotrophic lateral sclerosis (ALS) is a progressive, severe neurodegenerative disease caused by motor neuron death. Development of medicine for ALS urgently needed, and induced pluripotent cell-based drug repurposing identified Src/c-Abl inhibitor, bosutinib, as candidate molecular targeted therapy ALS. A phase 1 study confirmed the safety tolerability bosutinib in 12-week treatment patients. The objectives this are to evaluate efficacy longer-term
We reviewed 7 patients with unsuccessful endoscopic hemostasis using covered self-expandable metal stent (CSEMS) placement for post-endoscopic sphincterotomy (ES) bleeding. ES a medium incision was performed in 6 and large 1 patient. All but of them (86%) showed delayed bleeding, warranting second therapies followed by CSEMS 1–5 days after the initial ES. Subsequent did not achieve complete any patients. Lateral-side lines (3 or 9 o’clock) had more frequent bleeding points (71%) than...
Abstract Endoscopic pancreatic stenting is used to prevent main duct obstruction and relieve painful symptoms of chronic pancreatitis. However, the stent typically needs be exchanged rate adverse events high. Few studies have evaluated effect shape on those outcomes. We events, patency, total medical cost within 90 days patients who received an 8.5 French (Fr) physiologically shaped by comparing these features with associated a conventional straight-type for ≥ days. The stent-related event...