A5074319858- Ion channel regulation and function
- Anesthesia and Sedative Agents
- Cardiac electrophysiology and arrhythmias
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Medical History and Innovations
- Airway Management and Intubation Techniques
- History of Medical Practice
- Blood transfusion and management
- Pain Mechanisms and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Eicosanoids and Hypertension Pharmacology
- Metabolism and Genetic Disorders
- Ultrasound and Hyperthermia Applications
- Pharmacogenetics and Drug Metabolism
- History of Medicine Studies
- Chemical Reactions and Isotopes
- Drug Transport and Resistance Mechanisms
- Hemoglobin structure and function
- Poisoning and overdose treatments
- Muscle and Compartmental Disorders
- Electrolyte and hormonal disorders
- Olfactory and Sensory Function Studies
- Nitric Oxide and Endothelin Effects
- Nausea and vomiting management
Sapporo Toho Hospital
2016-2018
Ehime University Hospital
2018
Saitama Medical University Hospital
2009-2015
Saitama Medical University
2006-2011
Meikai University
2011
Hiroshima University Hospital
2011
Radboud University Nijmegen
2010
Radboud University Medical Center
2010
Japan Women's University
2010
Toho University
1991-2005
Malignant hyperthermia (MH) is a disorder of calcium homeostasis in skeletal muscle triggered by volatile anesthetics or succinylcholine susceptible persons. More than 100 mutations the ryanodine receptor type 1 gene (RYR1) have been associated with MH susceptibility, central core disease, both. RYR1 may account for up to 70% MH-susceptible cases. The authors aimed determine frequency and distribution Japanese population.The selected 58 unrelated diagnosed as having an enhanced Ca-induced Ca...
This study was undertaken to examine the dose-response effects of clinical concentrations halothane on activity wide-dynamic-range (WDR) neurons in dorsal horn spinal cord decerebrate, cord-transected cat. All cells (n = 40) responded maximally high-intensity (greater than 45 C) noxious heat stimulation. Following administration halothane, 0.5, 1.0, and 1.5 per cent, mean spontaneous discharge frequency significantly decreased (P < 0.01) by 44, 74, 87 respectively. The evoked frequencies...
Anatomic, physiologic and behavioral evidence suggests that the neurons in nucleus reticularis gigantocellularis of medial medullary reticular formation may act as a relay station for transmission nociceptive information from spinal cord to higher brain centers. The also be site action analgesic agents, such ketamine hydrochloride. Utilizing extracellular microelectrodes 23 decerebrate cats, authors measured effect on were excited by electrical stimulation peripheral nerves. frequency...
Bile salts of six different species the Anura were investigated by means thin-layer chromatography, gas-liquid and mass spectrometry. Xenopus laevis contained taurine-conjugated free forms 3α, 7α, 12α-trihydroxy-5β-cholestanoic acid 5β-cyprinol sulfate2) as its chief constituents. Smaller amounts cholic chenodeoxycholic also detected in hydrolyzed bile. Neither conjugated bile acids nor alcohol sulfates found Bombina orientalis, constituents which 12α-trihyboxy- 12α,...
CD1d-restricted invariant NKT (iNKT) cells play crucial roles in various types of immune responses, including autoimmune diseases, infectious diseases and tumor surveillance. The mechanisms underlying their adjuvant functions are well understood. Nevertheless, although IL-4 IL-10 production characterize iNKT able to prevent or ameliorate some inflammatory conditions, the precise by which exert regulatory function remain elusive. This study demonstrates that activation human specific ligand...
The serum and urinary concentrations of fluorinated metabolites isoflurane after inhalation three different were studied in 18 ASA physical status 1 or 2 patients, scheduled for orthopedic otolaryngeal surgery. Isoflurane was administered 60 min during fentanyl-nitrous oxide-oxygen, its end-tidal concentration maintained at 0.3, 0.6, 1.15% (groups I, II, III). organic fluorine determined by combustion fluoride ions analyzed ion chromatography. amounts expressed terms ion. increased...
Trifluoroacetate (TFA), the major metabolite of halothane, was assayed by a newly developed isotachophoretic technique. This technique has several advantages over presently used methods analysis. It requires no special preparation urine or blood samples. The sample volume is small (5--100 microliters) and analysis time short (30--90 min per sample). In addition, method provides an that both qualitative quantitative wide range concentrations (from 2 nanomoles in 200 microliters to 5...
We conducted this study to examine, in cerebral parenchymal arterioles, whether 20-hydroxyeicosatetraenoic acid (20-HETE) induces constrictor responses via superoxide and propofol reduces constriction.Electrical field stimulation or 20-HETE was applied rat brain slices monitored by computer-assisted microscopy. In some experiments, a Na(+) channel antagonist tetrodotoxin, synthesis inhibitor HET0016, scavenger, Tiron, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitors...
The metabolic sequence for the occurrence of an anomalous bile acid, 12-ketochenodeoxycholic acid (12-KCCA),* found in patients with hepatobiliary diseases was disclosed. 1. H-1 strain Staphylococcus epidermidis isolated from fistula a patient, which conjugated 12-KCCA detected, showed fairly strict substrate specificity 12α-hydroxysteroid dehydrogenation among acids and alcohols. 2. Only had ability to dehydrogenate cholic at 12-position, but hundred strains Staph. collected either nasal...
The effects of stone composition on transurethral lithotripsy (TUL) have not been sufficiently elucidated. purpose this study was to identify how calcium phosphate impacts TUL. Two hundred eighty-nine cases semi-rigid and/or flexible TUL for upper urinary tract calculi were reviewed retrospectively. Inclusion criteria a preoperative assessment by noncontrast computed tomography (NCCT) and analysis. Small stones those without excluded. Stone core radiodensity (SCR) measured taking the average...
The ability of 0.5% and 1.0% halothane to suppress neuronal activity cells in the nucleus reticularis gigantocellularis (NRGC) was studied decerebrate cats. These drug effects were examined order substantiate further potential involvement NRGC modulation transmission pain information. Only NRGC, which excited exclusively by electrical stimulation A-delta fibers superficial radial nerve, studied. Both concentrations caused a significant, dose-dependent reduction spontaneous evoked all...