A5101503338- Ocular Diseases and Behçet’s Syndrome
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Ocular Infections and Treatments
- Renal and Vascular Pathologies
- Non-Invasive Vital Sign Monitoring
- Advanced Data Storage Technologies
- Retinal and Macular Surgery
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Parallel Computing and Optimization Techniques
- Kidney Stones and Urolithiasis Treatments
- Advanced Data Compression Techniques
- Hemoglobinopathies and Related Disorders
- Ophthalmology and Visual Impairment Studies
- Bartonella species infections research
- Robotics and Automated Systems
- Antibiotics Pharmacokinetics and Efficacy
- Machine Learning in Bioinformatics
- Systemic Lupus Erythematosus Research
- Toxoplasma gondii Research Studies
- CNS Lymphoma Diagnosis and Treatment
- Bioinformatics and Genomic Networks
North Carolina State University
2022-2024
Midwest Eye Institute
2013-2024
Argonne National Laboratory
2023-2024
Duke University
2019-2023
Carolinas Medical Center
2021
Loma Linda University
1995-2020
Icahn School of Medicine at Mount Sinai
2018
University of Miami
2016
Florida College
1996-2008
University of Florida
1996-2008
Injection of pharmacotherapy into the suprachoroidal space, between sclera and choroid, is an alternative delivery technique developed with rationale providing higher drug concentrations to posterior ocular structures compared other intraocular periocular injection procedures. This study was conducted evaluate safety efficacy suprachoroidally injected triamcinolone acetonide formulation (CLS-TA), a suspension acetonide, in improving vision among patients noninfectious uveitis complicated by...
An in situ forming hydrogel was evaluated as a potential vitreous substitute rabbits.The used disulfide cross-linker that then reduced to produce an injectable thiol-containing polymer solution. The cross-links reformed by air oxidation of the thiols and produced stable once inside eye. clear, autoclavable, could be stored easily presence nitrogen gas. Capillary rheometry measure viscoelastic properties hydrogels porcine vitreous. Fourteen black rabbits underwent pars plana, 25-gauge,...
Purpose To assess the extended efficacy and safety of suprachoroidal triamcinolone acetonide injectable suspension (CLS-TA) among patients with macular oedema (ME) secondary to non-infectious uveitis (NIU). Methods Patients uveitic ME were treated CLS-TA at baseline week 12 Efficacy Safety Suprachoroidal for Macular Edema Secondary Noninfectious Uveitis: Phase 3 Randomized Trial (PEACHTREE) study. Time rescue was evaluated over 24 additional weeks MAGNOLIA. data, visual acuity retinal...
Purpose To evaluate local and systemic safety of suprachoroidal (SC) triamcinolone acetonide injectable suspension (CLS-TA) injections in subjects with non-infectious uveitis (NIU). Design Open-label, prospective multicentre study. Participants Thirty-eight NIU, without macular oedema (MO). Methods Treatment consisted two CLS-TA 4 mg, 12 weeks apart. Best-corrected visual acuity (BCVA), adverse event (AE) assessment, ophthalmic examinations optical coherence tomography (OCT) were conducted...
Purpose: This study assessed physician-investigator experience with suprachoroidal (SC) injections, an investigational therapeutic administration technique using a 900 or 1100 µm microneedle to inject drugs into the SC space. Methods: Datasets from six clinical trials across three diseases (noninfectious uveitis; diabetic macula edema, and retinal vein occlusion) were assessed. In addition user survey, retrospective correlations performed between procedural variables (needle length),...
BACKGROUND AND OBJECTIVE: To evaluate subfoveal choroidal thickness (CT) and the extent of outer retinal disruption in patients with macular telangiectasia type 2 (MacTel2) compared healthy eyes. PATIENTS METHODS: In this prospective, observational, cohort study, 62 (62 eyes) Mac-Tel2 130 controls (130 underwent a complete ophthalmological examination, spectral-domain optical coherence tomography (SD-OCT) imaging, axial length measurements. Patients study group also color fundus photography,...
Detecting cancer gene expression and transcriptome changes with mRNA-sequencing or array-based data are important for understanding the molecular mechanisms underlying carcinogenesis cellular events during progression. In previous studies, differentially expressed genes were detected across patients in one type. These studies ignored role of mRNA driving tumorigenic that either universal specific different tumor types. To address problem, we introduce two network-based multi-task learning...
To explore the efficacy of CLS-TA, a proprietary suprachoroidal injectable suspension triamcinolone acetonide, in noninfectious uveitis (NIU) with macular edema (ME), categorized by anatomic subtype.
Error-bounded lossy compression has been effective in significantly reducing the data storage/transfer burden while preserving reconstructed fidelity very well. Many error-bounded compressors have developed for a wide range of parallel and distributed use cases years. These are designed with distinct models design principles, such that each them features particular pros cons. In this paper we provide comprehensive survey emerging techniques different involving big to process. The key...
To compare the effects of zidovudine (ZDV) on clonal maturation hematopoietic progenitors obtained from bone marrow women child-bearing age with its marrow, liver and blood fetuses. We also sought to determine whether adverse ZDV fetal hematopoiesis resulted exclusively an action progenitors, or involved inhibition production growth factors.Hematopoietic were bone-marrow aspirates seven age, mid-trimester abortuses, umbilical cord term infants.We added increasing concentrations assays after...
ABSTRACT PURPOSE: To present a case of infectious keratitis occurring 6 years after LASIK due to the rare human pathogen Shewanella putrefaciens. METHODS: A 58-year-old man presented with redness and pain in right eye following retreatment. Examination revealed corneal infiltrate at flap interface. Corneal scraping stroma beneath was submitted for histopathologic microbiologic evaluation. RESULTS: An located interface originated from an epithelial defect flap-corneal junction. cultures...
Lossy compression is often deployed in scientific applications to reduce data footprint and improve transfers I/O performance. Especially for requiring on-the-flight compression, it essential minimize compression's runtime. In this paper, we design a scheme the performance of cuSZ, GPU-based lossy compressor. We observe that Huffman coding - used by cuSZ compress metadata generated during incurs overhead can be significant, especially smaller datasets. Our work seeks runtime with...
MRL-lpr/lpr mice manifest a systemic lupus-like autoimmune disease. As part of this syndrome, the spontaneously develop thyroiditis, which is morphologically and biochemically similar to human thyroiditis. In study we investigated whether thyroid tissue obtained from sites chronic inflammation had altered gap junctional communication. Fresh sections revealed that nondiseased (MRL-(+)/+) connexins (Cx) localized plasma membrane at points cell-cell contact. contrast, Cx in diseased mouse...
An intracranial pilocytic astrocytoma was diagnosed in a 13-year-old boy after he presented with headaches and visual disturbances. The initial ophthalmoscopic examination revealed papilledema bilaterally myelinated retinal nerve fibers (MRNFs) the left eye. Serial examinations demonstrated gradual fading of MRNFs beginning 2 months tumor resection their complete disappearance by years surgery. has been described presence ischemia, compression, glaucoma, demyelinating disease optic nerve....
Introduction: The purpose of this study was to evaluate factors during ureteroscopy that can potentially impact procedure cost. Materials and Methods: A retrospective review 129 consecutive elective cases performed determine direct Direct cost defined as incurred because operating room expenses, including time, staffing equipment, supply costs. Data regarding patient, procedural, characteristics were compared between the most least expensive cases. Univariate logistic regression analysis...
Photoplethysmography (PPG) and accelerometer (ACC) are commonly integrated into wearable devices for continuous unobtrusive pulse rate activity monitoring of individuals during daily life. However, obtaining clinically accurate respiratory measurements using such sensors remains a challenge. This article presents novel algorithm estimation respiration (RR) an upper-arm worn device by deriving multiple surrogate signals from PPG ACC sensing. RR is retrospectively evaluated on controlled...
Quantum circuit simulations enable researchers to develop quantum algorithms without the need for a physical computer. computing simulators, however, all suffer from significant memory footprint requirements, which prevents large circuits being simulated on classical super-computers. In this paper, we explore different lossy compression strategies substantially shrink tensors in QTensor package (a state-of-the-art tensor network simulator) while ensuring reconstructed data satisfy...
Nowadays, in hospitals, medical centers, farming, the military, on factory floors, each and every field application of robotics is increasing day by day. Line following robot one widely used robots. Basically, line an autonomous mobile system which follows has a different color from background. So performance these robots heavily depends upon its efficiency differentiating Many robotic events based are organized at college as well industry level all across world. In this paper, we have...
To obtain physicians' "real-world" perspectives on early experiences with triamcinolone acetonide suprachoroidal injection (SCS-TA) for treatment of patients uveitic macular edema (UME). Twelve retina/uveitis specialists in the United States were surveyed about SCS-TA procedure and patient outcomes. Survey participants administered ≥ 291 injections to 243 UME various disease characteristics (etiologies, chronicity, anatomical subtypes). Commonly reported reasons adoption included potential...