A5103209360- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Kidney Stones and Urolithiasis Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Neuroendocrine Tumor Research Advances
- Cardiomyopathy and Myosin Studies
- Neuroblastoma Research and Treatments
- IgG4-Related and Inflammatory Diseases
- Pleural and Pulmonary Diseases
- Pediatric Urology and Nephrology Studies
- Myasthenia Gravis and Thymoma
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Urological Disorders and Treatments
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Abdominal Trauma and Injuries
- Acute Myocardial Infarction Research
- Minimally Invasive Surgical Techniques
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pulmonary Hypertension Research and Treatments
- Blood Coagulation and Thrombosis Mechanisms
Sapporo Medical University
2015-2024
St. Marianna University School of Medicine
1994-2014
Sapporo University
2011-2014
American College of Chest Physicians
2013
RIKEN Advanced Science Institute
2012
Hamamatsu University School of Medicine
2009-2012
National Institute for Agro-Environmental Sciences
2012
Sapporo Medical University Hospital
2012
Oita University
1996
Jikei University School of Medicine
1987-1990
In the mammalian brain, suprachiasmatic nucleus (SCN) of anterior hypothalamus is considered to be principal circadian pacemaker, keeping rhythm most physiological and behavioral processes on basis light/dark cycles. Because restriction food availability a certain time day elicits anticipatory behavior even after ablation SCN, such has been assumed under control another oscillator. According recent studies, however, mutant mice lacking clock function exhibit normal food-anticipatory activity...
A case of a glomus tumor originating from the lung is reported. 43-year-old female had undergone resection right following clinical diagnosis carcinoid, sclerosing hemangioma, or other sarcoma. Histologically, comprised uniform small round to oval cells with centrally located nucleus, clear cytoplasm, and apparent cell borders. The also showed focally hemangiopericytomatous pattern irregularly branching dilated vessels. Electron microscopy revealed smooth muscle differentiation cells....
Diagnostic strategies for symptomatic transthyretin (ATTR) cardiac amyloidosis showing typical morphological features such as increased ventricular wall thickness and myocardial injury an elevation in serum troponin T level have been established, but those subclinical are limited. In the era when effective therapies to suppress/delay progression of ATTR available, early detection involvement plays a crucial role appropriate decision-making treatment TTR mutation carriers who family history...
Abstract Aims The role of necroptosis in dilated cardiomyopathy (DCM) remains unclear. Here, we examined whether phosphorylation mixed lineage kinase domain‐like protein (MLKL), an indispensable event for execution necroptosis, is associated with the progression DCM. Methods and results Patients DCM ( n = 56, 56 ± 15 years age; 68% male) were enrolled immunohistochemical analyses biopsies. Adverse events defined as a composite death or admission heart failure ventricular arrhythmia. Compared...
A 70-year-old man with T1N3M1 stage IV squamous cell carcinoma in the right upper lobe of lung developed chylothorax and chylopericardium as rare simultaneous complications. Intravenous hyperalimentation, repeated pleurodesis, ligation thoracic duct were all ineffective. pleuroperitoneal shunt was inserted into pleural cavity from fifth intercostal space, a peritoneal catheter placed abdominal cavity. Chylothorax markedly improved, quality life patient increased. This case indicates that can...
IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder characterized by lymphoplasmacytic infiltration of numerous IgG4-positive plasma cells, leading to fibrous thickening in the affected tissue. Typical cardiovascular manifestations IgG4-RD are periaortitis, coronary arteritis, and pericarditis. Rare cases myocardial involvement have been reported, but surgical resection or open biopsy was required for diagnosis those cases. Here, we report case which percutaneous transcatheter...
Malignant pleural mesothelioma (MPM) is thought to arise from the mesothelial cells that line cavities. Most patients initially experience insidious onset of chest pain or shortness breath and have a history asbestos exposure. MPM rarely presents as spontaneous pneumothorax. We report two male who presented with hydropneumothorax. One was exposed other not. Computed tomography showed tiny nodules thickness. They both underwent effusion cytology and/or biopsy. Therefore, pathological...
We report an unusual case of sarcoidosis associated with bilateral hydronephrosis. The patient was a 53-year-old Japanese woman who presented dysuria and urinary incontinence. Computed tomography the abdomen showed hydronephrosis caused by retroperitoneal mass, surrounded enlarged lymph nodes. Histological examination mass demonstrated noncaseating epithelioid cell granulomas involving Corticosteroid therapy led to complete resolution This emphasizes that should be included in differential...
Systemic urticaria in a 64-year-old woman was diagnosed as leukocytoclastic vasculitis by punch biopsy of the skin. Her physical findings improved after prescription prednisolone at dose 20 mg/day, but skin rash relapsed with renal dysfunction, proteinuria, and hematuria when reduced over period 9 months to 1 mg/day. She admitted our institute for further examination, urinary protein plasma creatinine levels were 0.8 g/day 1.7 mg/dL, respectively. Complement analysis showed that total...
Background: Few studies have examined if two score systems of coronary stenosis, SYNTAX and Gensini score, are different as predictors prognosis in patients with artery disease (CAD). Here we this issue stable CAD after percutaneous intervention (PCI). Methods: We retrospectively analyzed 795 consecutive who underwent angiography for suspected from January 2007 to August 2012. One hundred fifty-nine received PCI according consensus the Heart Team our institute patients’ consents. Overall...
Implantable cardioverter defibrillator (ICD) and cardiac resynchronization with a (CRT-D) are established therapies for secondary prevention of sudden death (SCD) in patients structural heart disease (SHD), but the rates subsequent ICD/CRT-D therapy widely differ among SHD. The aim this study was to determine clinical factors associated appropriate preventing SCD SHD.We enrolled 147 SHD (mean age, 59 ± 15 years; mean ejection fraction [EF], 45 15%) who underwent implantation (ischemic...
Background:Demonstration of exit block from the pulmonary vein (PV) to left atrium after PV isolation (PVI) is not always possible demonstration entrance block. We examined factors associated with demonstrable and relationship between subsequent reconnection.
背景．肺の定型的カルチノイドでリンパ節転移を示す例は少ない．血清adrenocorticotropic hormone（ACTH），progastrin-releasing peptide（pro-GRP）高値で，縦隔リンパ節転移陽性の1例を経験したので報告する．症例．41歳，女性．ふらつきを主訴に当院内科を受診し，内分泌学的検索からCushing症候群と診断された．中葉に最大径11 mmの腫瘤を認め，異所性ACTH産生腫瘍が疑われ，確定診断目的で当科へ紹介された．術中迅速病理診断はカルチノイドで，リンパ節郭清（ND2a-1）を伴う中葉切除を施行した．最終病理診断は定型的カルチノイドで，右下部気管傍リンパ節（#4R）転移陽性，pT1aN2M0，p-stage IIIAであった．上昇していたACTH，pro-GRPは，術後に正常域となった．化学療法を追加し，術後20か月を経た現在，再発を認めていない．結論．肺定型的カルチノイドであってもリンパ転移陽性例があることを念頭に置く必要がある．
Abstract Background Catheter ablation is an effective treatment for atrial fibrillation (AF), but it carries risk of perioperative thromboembolism even in cases with low CHADS2 scores. Here, we examined whether a combination clinical variables can predict stroke factors that are assessed by transesophageal echocardiography (TEE). Methods The study population consisted 209 consecutive AF patients score 0 or 1 (58.7 ± 10.6 years old; persistent AF, 33.0%). All underwent TEE, and TEE‐determined...
An 86-year-old woman with a history of right breast cancer resected seven years ago had small pulmonary nodule located in left S5. Diagnosis was made by bronchoscopy using the endobronchial ultrasonography-guided sheath (EBUS-GS) method, but histological diagnosis not obtained. Wedge resection performed due to suspicion metastatic lesion from based on radiological findings. The tumor subsequently found be malignant melanoma lung. initial primary lung because at another site seen despite...