A5019422274- Carbohydrate Chemistry and Synthesis
- Glaucoma and retinal disorders
- Molecular spectroscopy and chirality
- Glycosylation and Glycoproteins Research
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Natural product bioactivities and synthesis
- Ophthalmology and Eye Disorders
- Retinal Diseases and Treatments
- Analytical Chemistry and Chromatography
- Corneal surgery and disorders
- Microbial Metabolites in Food Biotechnology
- Retinopathy of Prematurity Studies
- Corneal Surgery and Treatments
- Retinal and Macular Surgery
- Retinal Imaging and Analysis
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Ophthalmology and Visual Impairment Studies
- Ocular Surface and Contact Lens
- Facial Rejuvenation and Surgery Techniques
- Retinal Development and Disorders
- Seaweed-derived Bioactive Compounds
- Phytochemistry and Biological Activities
- Supramolecular Self-Assembly in Materials
Northwestern University
2025
Universidad de La Laguna
2008-2023
Canary Institute of Cancer Research
2016
Hospital de Sant Pau
2011
Secretaria de Salud
2009
Instituto de Productos Naturales y Agrobiología
1989-2004
Universidad de Zaragoza
1998-2003
Université Libre de Bruxelles
2003
Consejo Nacional de Investigaciones Científicas y Técnicas
2001
Consejo Superior de Investigaciones Científicas
1991-2000
Background Between 5 and 25 April 2009, pandemic (H1N1) 2009 caused a substantial, severe outbreak in Mexico, subsequently developed into the first global 41 years. We determined reproduction number of by analyzing dynamics complete case series Mexico City during this early period. Methods analyzed three mutually exclusive datasets from Distrito Federal which constituted all suspect cases 15 March to April: confirmed infections, non‐pandemic influenza A infections patients who tested...
Chronic corneal inflammation, a component of sulfur mustard (SM) and nitrogen (NM) injuries frequently leads to limbal stem cell deficiency (LSCD), which can compromise vision. Corneal conjunctivalization, neovascularization, persistent inflammation are hallmarks LSCD. Ocular exposure SM NM results in an acute delayed phase disruption, culminating Available therapies for keratopathy (e.g., topical corticosteroids) often have adverse side effects, generally ineffective preventing the...
The present report undertakes a challenge of general interest in supramolecular chemistry: the achievement helical organizations with controlled structure. To achieve this target we considered possibility inducing chirality using molecules that were designed to organize into columnar mesophases. use oxazoline-derived ligands and metal coordination served as tools prepare phasmidic-like structure, which show organization liquid crystalline state. ensure formation chiral mesophases, these...
Chiral oxovanadium(IV), copper(II), and palladium(II) β-diketonates show a room-temperature columnar mesophase which undergoes ferroelectric switching. All the compounds were obtained as liquid crystals at room temperature, crystallization or melting processes not detected by differential scanning calorimetry carried out to −20 °C. The was investigated optical microscopy, DSC X-ray diffraction, identified rectangular (P21). flowerlike texture observed for all led us deduce high tilt angle...
The thyroid hormone and retinol transporter protein known as transthyretin (TTR) is in the origin of one 20 or so amyloid diseases. TTR self assembles a homotetramer leaving central hydrophobic channel with two symmetrical binding sites. aggregation pathway into amiloid fibrils not yet well characterized but vitro hormones other small organic molecules to results tetramer stabilization which prevents formation an extent proportional constant. Up now, inhibitors have been designed looking at...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselective Synthesis of Seven-Membered Carbocycles from 2-Amino-1,3-butadienes and Vinyl Chromium Fischer-Type CarbenesJose Barluenga, Fernando Aznar, Alfredo Martin, Jesus T. VazquezCite this: J. Am. Chem. Soc. 1995, 117, 37, 9419–9426Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPairwise additivity in exciton-coupled CD curves of multichromophoric systemsWilliam T. Wiesler, Jesus Vazquez, and Koji NakanishiCite this: J. Am. Chem. Soc. 1987, 109, 19, 5586–5592Publication Date (Print):September 1, 1987Publication History Published online1 May 2002Published inissue 1 September 1987https://doi.org/10.1021/ja00253a005RIGHTS & PERMISSIONSArticle Views177Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXT[3 + 2] Cycloaddition of Fischer Alkenyl Carbene Complexes to Enamines: An Efficient Asymmetric Approach CyclopentanoidsJosé Barluenga, Miguel Tomás, Alfredo Ballesteros, Javier Santamaría, Cecile Brillet, Santiago García-Granda, Alejandro Piñera-Nicolás, and Jesús T. VázquezView Author Information Instituto Universitario de Química Organometálica "E. Moles" Departamento Física y Analítica Universidad Oviedo, 33071-Oviedo, Spain Bio-Orgánica...
Sixteen methyl glucopyranosyl glucopyranoside disaccharides (methyl β-d-Glcp(p-Br-Bz)-(1→x)-β/α-d-Glcp) containing β-glycosidic linkages (1→2, 1→3, 1→4, and 1→6) were synthesized analyzed by means of CD NMR spectroscopy in three different solvents. For each these four types disaccharides, a correlation was observed between the hydroxymethyl rotational populations around C5−C6 bond residue II with substituents anomeric configuration methoxyl group I, as well solvent. Nonbonded interactions,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCD and 1H NMR Study of the Rotational Population Dependence Hydroxymethyl Group in .beta. Glucopyranosides on Aglycon Its Absolute ConfigurationEzequiel Q. Morales, Juan I. Padron, Mar Trujillo, Jesus T. VazquezCite this: J. Org. Chem. 1995, 60, 8, 2537–2548Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April...
Two new C13-norisoprenoid compounds, (3S,5R,6S,9R)-3,6-dihydroxy-5,6-dihydro-β-ionol (1) and (3S,4S,5S,6S,9S)-3,4-dihydroxy-5,6-dihydro-β-ionol (2), were isolated from the leaves of Apollonias barbujana. The absolute structures determined by spectroscopic methods chemical transformations. (3S,4S,5S,6S,9R)-3,4-Dihydroxy-5,6-dihydro-β-ionol (3) was also isolated, structure which has been X-ray analysis whose 1H-NMR, 13C-NMR, MS data are reported herein.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTetra-O-benzoylglucosylation: A New 1H Nuclear Magnetic Resonance Method for Determination of the Absolute Configuration Secondary AlcoholsMar Trujillo, Ezequiel Q. Morales, and Jesus T. VazquezCite this: J. Org. Chem. 1994, 59, 22, 6637–6642Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November...
Abstract
Abstract Chiral 2‐amino‐1,3‐butadienes 1 derived from commercially available ( S )‐2‐methoxymethylpyrrolidine react with aromatic N ‐trimethylsilylaldimines and ‐phenylaldimines in the presence of ZnCl 2 to give, after reaction workup, 4‐piperidones 4 6 , respectively, moderate very high enantiomeric excesses. In addition, absolute configurations derivatives a g were determined by circular dichroism NMR spectroscopy on Mosher ester, respectively.
The rotational populations of the hydroxymethyl group in chiral and nonchiral alkyl α- β-galactopyranosides proved, on basis circular dichroism (CD) 1H NMR data, to be dependent structure aglycon: population gt tg rotamers increased decreased, respectively, as pKa bonded alcohol (aglycon) increased, while gg rotamer remained practically constant. Furthermore, low-temperature CD measurements proved that most stable is gt, not tg. In addition, a clear correlation between absolute configuration...
Chemoprevention of human cancer appears to be a feasible strategy for control, especially when chemopreventive intervention is involved during early stages the carcinogenesis process. As part our ongoing research program into new agents, herein are reported isolation, structural elucidation, and biological evaluation 10 (1–10) three known (11–13) sesquiterpenes with dihydro-β-agarofuran skeleton from leaves Maytenus jelskii Zahlbr. Their stereostructures have been elucidated by means...
The reaction of a mixture [NPCl2]n and Cs2CO3 first with (R)-(+)-1,1'-binaphthyl-2,2'-diol (HO−C10H6−C10H6−OH) (binaphthol) subsequently phenol (HO−C6H5) in refluxing 1,4-dioxane gave the series optically active random copolymers {[NP(O2C20H12)]x[NP(OC6H5)2]1-x}n (2). Absolute molecular weight distributions radius gyration have been determined by size exclusion chromatography, using simultaneously multiangle light scattering differential refractive index detectors. dependence dimensions...