A5066771790- Cellular transport and secretion
- Pluripotent Stem Cells Research
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Congenital Heart Disease Studies
- Lipid Membrane Structure and Behavior
- RNA Research and Splicing
- Blood Coagulation and Thrombosis Mechanisms
- Genetic Neurodegenerative Diseases
- Bladder and Urothelial Cancer Treatments
- Nephrotoxicity and Medicinal Plants
- Chemical Reactions and Isotopes
- Neurobiology and Insect Physiology Research
- 3D Printing in Biomedical Research
- Sphingolipid Metabolism and Signaling
- Viral-associated cancers and disorders
- Axon Guidance and Neuronal Signaling
- Anesthesia and Neurotoxicity Research
- Signaling Pathways in Disease
- Appendicitis Diagnosis and Management
- MicroRNA in disease regulation
- Tissue Engineering and Regenerative Medicine
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Gene expression and cancer classification
University of Toronto
2016-2025
Creighton University
2021
University of Nebraska Medical Center
2006-2017
Harvard–MIT Division of Health Sciences and Technology
2017
Massachusetts Institute of Technology
2017
Harvard University
2017
Harvard Stem Cell Institute
2017
Brigham and Women's Hospital
2017
Ontario Institute for Cancer Research
2017
University of California, San Diego
2002
During gastrulation, Wnt-β-catenin signaling dictates lineage bifurcation generating different mesoderm cell types. However, the specific role of Wnt receptors in specification remains elusive. Using selective Frizzled (FZD) and LRP5/6 antibody-based agonists, we examined FZD receptors' function during directed differentiation human pluripotent stem cells (hPSCs). We found that FZD2 FZD7 are expressed at membrane hPSCs their activation triggers β-catenin with kinetics, thereby influencing...
The Wnt/β-catenin signaling governs anterior-posterior neural patterning during development. Current human pluripotent stem cell (hPSC) differentiation protocols use a GSK3 inhibitor to activate Wnt promote posterior fate specification. However, is pleiotropic kinase involved in multiple pathways and, as inhibition occurs downstream the cascade, it bypasses potential opportunities for achieving specificity or regulation at receptor level. Additionally, specific roles of individual FZD...
Background Urolithiasis affects an estimated 5% of the population and lifetime risk passing a stone in urinary tract is to be 8–10%. Urinary calculus formation highly variable while certain factors such as age, gender, seasonality, anatomic abnormality, metabolic diseases have been identified, not much known regarding association environmental lunar phases on renal colic. We conducted retrospective study test hypothesis that full moon phase factor associated for increased emergency...
Activation of the Wnt signalling pathway is vital in anterior-posterior patterning during neural development. In a new study, Stephane Angers and colleagues leverage previously developed selective antibodies against Frizzled receptors to stimulate midbrain progenitor differentiation human pluripotent stem cells. We caught up with first author Andy Yang corresponding Angers, Professor at University Toronto, learn more about story behind paper.
Abstract The Cancer Genome Collaboratory is an academic compute cloud designed to enable computational research on the world’s largest and most comprehensive cancer genome dataset, International Consortium (ICGC). ICGC target categorize genomes of 25,000 tumors by 2018. A subproject ICGC, PanCancer Analysis Whole Genomes (PCAWG) alone has generated over 800TB harmonized sequence alignments, variants interpreted data from 2,800 patients. dataset this size requires months download significant...
Abstract The goal of the International Cancer Genome Consortium (ICGC) is to analyze cancer genomes at least 500 tumour samples with matched controls from 50 different types and subtypes, building a comprehensive catalogue somatic abnormalities for benefit research community. amount data ICGC members will generate close that 50,000 human genome projects and, date, has received commitments 107 study more than 27,000 tumor genomes. Data Coordination Center (DCC) responsible collecting,...
Abstract Glioblastoma stem cells (GSCs) exhibit latent neuronal lineage differentiation potential governed by the proneural transcription factor Achaete-scute homolog 1 (ASCL1) and harnessing promoting terminal has been proposed as a novel therapeutic strategy. Here, using genome-wide CRISPR suppressor screen we identified genes required for ASCL1-mediated differentiation. This approach revealed specialized function of Mediator complex tail module its subunits MED24 MED25 this process in...