A5063541239- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Polysaccharides and Plant Cell Walls
- Hydrogels: synthesis, properties, applications
- Plant tissue culture and regeneration
- Natural product bioactivities and synthesis
- Plant Molecular Biology Research
- Transgenic Plants and Applications
- biodegradable polymer synthesis and properties
- Plant Stress Responses and Tolerance
- Polymer Surface Interaction Studies
- Cancer Research and Treatments
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Advanced Polymer Synthesis and Characterization
- Pharmacological Receptor Mechanisms and Effects
- RNA modifications and cancer
- Neuropeptides and Animal Physiology
- Photosynthetic Processes and Mechanisms
- Biofuel production and bioconversion
- Protein Degradation and Inhibitors
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- Ferrocene Chemistry and Applications
- Bioactive natural compounds
Heilongjiang University of Chinese Medicine
2015-2024
Qingdao University
2018-2024
Affiliated Hospital of Qingdao University
2018-2024
Heilongjiang Vocational Institute of Ecological Engineering
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
Stony Brook University
2018-2023
Shihezi University
2021-2023
Northeast Forestry University
2019-2022
Dana-Farber Cancer Institute
2021
Harvard University
2021
Fusion-transcription factors (fusion-TFs) represent a class of driver oncoproteins that are difficult to therapeutically target. Recently, protein degradation has emerged as strategy target these challenging oncoproteins. The mechanisms regulate fusion-TF stability, however, generally unknown. Using CRISPR-Cas9 screening, we discovered tripartite motif-containing 8 (TRIM8) an E3 ubiquitin ligase ubiquitinates and degrades EWS/FLI, in Ewing sarcoma. Moreover, identified TRIM8 selective...
Mutations in the MECP2 gene underlie a spectrum of neurodevelopmental disorders, most commonly Rett syndrome (RTT). We ask whether mutations interfere with human astrocyte developmental maturation, thereby affecting their ability to support neurons. Using human-based models, we show that RTT-causing greatly impact key role astrocytes regulating overall brain bioenergetics and these metabolic aberrations are likely mediated by dysfunctional mitochondria. During post-natal rely on neurons...
Abstract Breast cancer is a major threat to safety and health of women. The breast stem cells (BCSCs) have multi-drug resistance chemotherapy drugs, which leads failure. We proposed strategy delivery tumor-killing drugs reversal agent, enhance inhibition BCSCs. Here, schisandrin B (SchB)/AP NPs are constructed using acid-grafted-poly (β-amino ester) (ATRA-g-PBAE, AP) grafted polymer nanoparticle encapsulated SchB, with pH-sensitive release function. This drug system has good pharmacological...
Significance Rett syndrome (RTT) is a severe neurological disease affecting girls in their early childhood. The underlying cause of most RTT cases mutations the gene methyl-CpG-binding protein 2 ( MECP2 ). How loss MeCP2 function brain due to these causes such symptoms remains mystery. Here, we show widespread aberrations expression and anomalous patterns alternative splicing, specifically when neurons mice are stimulated. Furthermore, occur conjunction with higher seizure susceptibility...
Immunomodulatory drugs are a class of approved for the treatment multiple myeloma. These compounds exert their clinical effects by inducing interactions between CRL4
Poly(N-acryloyl glycinamide) (PNAGA) can form high-strength hydrogen bonds (H-bonds) through the dual amide motifs in side chain, allowing polymer to exhibit gelation behavior and an upper critical solution temperature (UCST) property. These features make PNAGA a candidate platform for biomedical devices. However, most applications focused on hydrogels, while few nanoparticles. Improving UCST tunability bio-interfacial adhesion of nanoparticles may expand their fields. To address issues, we...
PEG-poly(β-amino ester) (PEG-PBAE), which is an effective pH-responsive copolymer, was mainly synthesized by Michael step polymerization. Thioridazine (Thz), reported to selectively eliminate cancer stem cells (CSCs), loaded into PEG-PBAE micelles (PPM) prepared self-assembly at low concentrations. The critical micelle concentrations (CMC) of PPM in water were 2.49 μg/mL. PBAE segment soluble due protonated tertiary amine groups when the pH decreased below 6.8, but it insoluble 7.4....
pH-responsive and CD44 receptor-mediated targeted nanoparticles for eliminating cancer stem cells (CSCs) were developed based on complexes of PEG-poly(β-amino ester) (PEG-PBAE) micelles (PPM) coated with hyaluronic acid (HA) (HA-coated PPM complex, or HPPMc). Thioridazine (Thz) was loaded into HPPMc a decent drug loading content. The release results the in vitro showed that Thz released from HPPMc, which stimulated by both acidic pH specific enzymes. Cytotoxicity studies mammospheres (MS)...
Polymer–protein hybrids have been extensively used in biomedical fields. Polymers with upper critical solution temperature (UCST) behaviors can form a hydrated coacervate phase below the cloud point (Tcp), providing themselves opportunity to directly capture hydrophilic proteins and aqueous solutions. However, it is always challenge obtain UCST polymer that could aggregate at high relatively low concentration also efficiently bind proteins. In this work, reactive was designed, its...
Abstract Poly(methylacrylamide) (PMAM) is a thermo‐responsive polymer with an upper critical solution temperature (UCST). Its cloud point ( T cp ) around 60 °C, unsuitable for certain biomedical and industrial applications. This study brought up copolymerization strategy to tune the of PMAM hydrophilic comonomers. Surprisingly, small portion monomer doped, copolymer can be significantly shifted. For instances, ≤7 mol% acrylamide or 1 oligo(ethylene glycol) methacrylate, shifted in wide range...
The sensitivity of cotton to salt stress depends on the genotypes and types. Understanding mechanism ion homeostasis under different stresses is necessary improve performance saline conditions. A pot experiment using three (NaCl+Na2SO4), alkaline (Na2CO3+NaHCO3), saline-alkaline (NaCl+Na2SO4+Na2CO3+NaHCO3) two varieties (salt-tolerant variety L24 salt-sensitive G1) was conducted. growth, concentrations, Na+ transport-related gene expression in were determined. inhibitory effects growth...
The xylanase B gene encoding a thermostable family 10 of Clostridium stercorarium was expressed in plants under the control constitutive promoter. Two forms gene, xynB full length including bacterial signal sequence and xynBM without region, were introduced into tobacco BY-2 cells respectively cauliflower mosaic virus 35S Transgenic showed activity normal growth. recombinant enzyme produced transgenic harboring secreted culture supernatant, localized cells. In contrast to plants, expression...
Phosphorus (P) deficiency affects plant yield and quality, yet at the same time, excessive phosphorus application does not necessarily promote growth of plants. How to maintain a balance between biomass accumulation is problem. Therefore, purpose this research was explore relationship quality Bupleurum fertilization, based on three fertilization levels (20 kg∙ha-1; 10 0 kg∙ha-1). We adopted gas chromatography-mass spectrometry assess response primary metabolites different tissues (flowers,...
'Biased' ligands of G protein-coupled receptors (GPCRs) represent a type promising analgesic with reduced on-target side effects. PZM21, potent μ-opioid-receptor (μOR)-biased agonist new chemical scaffold compared to classic opioids, has been identified as therapeutic lead molecule for treating pain. In the current study, novel PZM21 analogues were synthesized and evaluated their in vitro vivo efficacy. Novel compound 7a demonstrated undetectable β-arrestin-2 recruitment, however, effects...
Bupleurum (Apiaceae) is widely used in traditional Chinese medicine to treat inflammatory and infectious diseases. Although roots are the only parts China, other countries use whole plant. The yield quality of depend mainly on fertilizers, especially nitrogen. current study aimed assess relationship between nitrogen fertilization level metabolomic response different (flowers, main shoots, lateral shoots roots) three levels (control group: 0 kg·ha−1; low-nitrogen 55 high-nitrogen 110...